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- W3208596379 abstract "<h3>Objectives</h3> To evaluate the impact of intraoperative hypotension and hemodynamic instability on survival outcomes in patients with high-grade serous ovarian carcinoma (HGSOC). <h3>Methods</h3> We retrospectively identified patients with HGSOC, who underwent primary or interval debulking surgery between August 2013 and December 2019. We collected anesthesia-related variables, including the arterial blood pressure measurements (at 1-min interval) during surgery of patients. The cumulative duration of mean arterial blood pressure (MAP) readings under 65 mmHg and two performance measurements (median performance error [MDPE] and wobble) were calculated. We investigated associations between the factors indicating hemodynamic instability and prognosis. <h3>Results</h3> In total, 338 patients were included. Based on the cumulative duration of MAP under 65 mmHg, we divided patients into two groups: ≥30 min and <30 min. The progression-free survival (PFS) was worse in the ≥30 min group (n=107) than the <30 min group (n=231) (median, 18.2 vs. 23.7 months; P=0.014). In multivariate analysis adjusting for confounders, a duration of ≥30 min of MAP under 65 mmHg was identified as an independent poor prognostic factor for PFS (adjusted HR, 1.376; 95% CI, 1.035–1.830; P=0.028). Shorter PFS was observed in the group with a MDPE <4.0% (adjusted HR, 1.351; 95% CI, 1.024–1.783; P=0.033) and a wobble ≥7.5% (adjusted HR, 1.445; 95% CI, 1.100–1.899; P=0.008). However, no differences were observed in overall survival. <h3>Conclusions</h3> The three intraoperative variables for hemodynamic instability, cumulative duration of MAP <65 mmHg, MDPE, and wobble, might be novel prognostic biomarkers for disease recurrence in patients with HGSOC." @default.
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- W3208596379 date "2021-11-01" @default.
- W3208596379 modified "2023-10-14" @default.
- W3208596379 title "EPV210/#490 Prognostic implications of hemodynamic instability during ovarian cancer surgery" @default.
- W3208596379 doi "https://doi.org/10.1136/ijgc-2021-igcs.281" @default.
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