FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208621807> ?p ?o ?g. }

• W3208621807 abstract "Ferroptosis is a new type of cell death different from apoptosis, necrosis, autophagy, and pyroptosis. This study aimed to explore the relationship between ferroptosis-related noncoding RNA (ncRNA) and gastric adenocarcinoma with regard to immunity and prognosis.Ferroptosis-related ncRNA expression profiles and clinical pathology and overall survival information were collected from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus database. The ferroptosis-related ncRNA signature was identified by Cox regression analysis and the least absolute shrinkage and selection operator analysis. The survival analysis, receiver operating characteristic (ROC) analysis, and decision curve analysis were adopted to evaluate the prognostic prediction performance of the signature. The correlation between risk and multiple clinical characteristics was analyzed using the chi-square test. The Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis were used for mining functions and pathways. The CIBERSORT, ssGSEA, and ESTIMATE algorithms were used to assess immune infiltration and the tumor microenvironment. The response of immunotherapy was predicted using the Submap algorithm, and the Connectivity Map and the ridge regression model were used to screen and evaluate drugs.A carcinogenic risk signature was constructed using five ferroptosis-related ncRNAs. It showed an extraordinary ability to predict the prognoses of patients with gastric adenocarcinoma [area under the ROC curve (AUC) after 6 years = 0.689; GSE84426, AUC after 6 years = 0.747]. The lower ferroptosis potential level and lower tumor mutation burden were related to the poor prognoses of patients. The high-risk group had more immune cell recruitment, and the overall effect of the anti-immune checkpoint immunotherapy was not as good as that of the low-risk group. The high- and low-risk groups were enriched in tumor- and immune-related pathways, respectively. The screened antitumor drugs, such as genistein, guanabenz, and betulinic acid, improved the survival of the patients.The ferroptosis-related ncRNA signature is a potential carcinogenic prognostic biomarker of gastric adenocarcinoma." @default.
• W3208621807 created "2021-11-08" @default.
• W3208621807 creator A5014473034 @default.
• W3208621807 creator A5014947716 @default.
• W3208621807 creator A5032162374 @default.
• W3208621807 creator A5036733201 @default.
• W3208621807 creator A5053339082 @default.
• W3208621807 date "2021-11-01" @default.
• W3208621807 modified "2023-09-25" @default.
• W3208621807 title "The Ferroptosis-Related Noncoding RNA Signature as a Novel Prognostic Biomarker in the Tumor Microenvironment, Immunotherapy, and Drug Screening of Gastric Adenocarcinoma" @default.
• W3208621807 cites W1967039732 @default.
• W3208621807 cites W2001775594 @default.
• W3208621807 cites W2065634756 @default.
• W3208621807 cites W2076930147 @default.
• W3208621807 cites W2091129202 @default.
• W3208621807 cites W2265062179 @default.
• W3208621807 cites W2470477092 @default.
• W3208621807 cites W2597573969 @default.
• W3208621807 cites W2735809102 @default.
• W3208621807 cites W2741309469 @default.
• W3208621807 cites W2770434260 @default.
• W3208621807 cites W2779697658 @default.
• W3208621807 cites W2796207838 @default.
• W3208621807 cites W2800840044 @default.
• W3208621807 cites W2886498337 @default.
• W3208621807 cites W2899221562 @default.
• W3208621807 cites W2901242178 @default.
• W3208621807 cites W2902110999 @default.
• W3208621807 cites W2912652186 @default.
• W3208621807 cites W2916964158 @default.
• W3208621807 cites W2917673897 @default.
• W3208621807 cites W2918297277 @default.
• W3208621807 cites W2940561057 @default.
• W3208621807 cites W2943793962 @default.
• W3208621807 cites W2945071464 @default.
• W3208621807 cites W2946860111 @default.
• W3208621807 cites W2969338379 @default.
• W3208621807 cites W2972190637 @default.
• W3208621807 cites W2974568688 @default.
• W3208621807 cites W2981370517 @default.
• W3208621807 cites W2988712095 @default.
• W3208621807 cites W2999516544 @default.
• W3208621807 cites W3001529513 @default.
• W3208621807 cites W3002849039 @default.
• W3208621807 cites W3004329125 @default.
• W3208621807 cites W3004649412 @default.
• W3208621807 cites W3008780955 @default.
• W3208621807 cites W3009077651 @default.
• W3208621807 cites W3012668557 @default.
• W3208621807 cites W3020708082 @default.
• W3208621807 cites W3036124412 @default.
• W3208621807 cites W3036883674 @default.
• W3208621807 cites W3050108631 @default.
• W3208621807 cites W3080394884 @default.
• W3208621807 cites W3081748491 @default.
• W3208621807 cites W3093072048 @default.
• W3208621807 cites W3144218037 @default.
• W3208621807 cites W3163588625 @default.
• W3208621807 cites W3166825619 @default.
• W3208621807 cites W3170359222 @default.
• W3208621807 cites W3175752499 @default.
• W3208621807 cites W3176506185 @default.
• W3208621807 cites W3184235341 @default.
• W3208621807 doi "https://doi.org/10.3389/fonc.2021.778557" @default.
• W3208621807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8591298" @default.
• W3208621807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34790582" @default.
• W3208621807 hasPublicationYear "2021" @default.
• W3208621807 type Work @default.
• W3208621807 sameAs 3208621807 @default.
• W3208621807 citedByCount "7" @default.
• W3208621807 countsByYear W32086218072022 @default.
• W3208621807 countsByYear W32086218072023 @default.
• W3208621807 crossrefType "journal-article" @default.
• W3208621807 hasAuthorship W3208621807A5014473034 @default.
• W3208621807 hasAuthorship W3208621807A5014947716 @default.
• W3208621807 hasAuthorship W3208621807A5032162374 @default.
• W3208621807 hasAuthorship W3208621807A5036733201 @default.
• W3208621807 hasAuthorship W3208621807A5053339082 @default.
• W3208621807 hasBestOaLocation W32086218071 @default.
• W3208621807 hasConcept C104317684 @default.
• W3208621807 hasConcept C10515644 @default.
• W3208621807 hasConcept C121608353 @default.
• W3208621807 hasConcept C126322002 @default.
• W3208621807 hasConcept C143998085 @default.
• W3208621807 hasConcept C145059251 @default.
• W3208621807 hasConcept C150194340 @default.
• W3208621807 hasConcept C194993378 @default.
• W3208621807 hasConcept C2777701055 @default.
• W3208621807 hasConcept C2779733811 @default.
• W3208621807 hasConcept C502942594 @default.
• W3208621807 hasConcept C50382708 @default.
• W3208621807 hasConcept C54355233 @default.
• W3208621807 hasConcept C58471807 @default.
• W3208621807 hasConcept C62203573 @default.
• W3208621807 hasConcept C67705224 @default.
• W3208621807 hasConcept C70721500 @default.
• W3208621807 hasConcept C71924100 @default.
• W3208621807 hasConcept C86803240 @default.
• W3208621807 hasConceptScore W3208621807C104317684 @default.
• W3208621807 hasConceptScore W3208621807C10515644 @default.

• next