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- W3208623744 abstract "The PtIV prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3-fold enhancement in drug concentration compared to passive loading strategies. A strain-promoted cycloaddition reaction (azide- dibenzocyclooctyne) was used to attach iproplatin-loaded liposomes L(Pt) to gas-filled microbubbles (M), forming an ultrasound-responsive drug delivery vehicle [M-L(Pt)]. Ultrasound-triggered release of iproplatin from the microbubble-liposome construct was evaluated in cellulo. Breast cancer (MCF-7) cells treated with both free iproplatin and iproplatin-loaded liposome-microbubbles [M-L(Pt)] demonstrated an increase in platinum concentration when exposed to ultrasound. No appreciable platinum uptake was observed in MCF-7 cells following treatment with L(Pt) only or L(Pt)+ultrasound, suggesting that microbubble-mediated ultrasonic release of platinum-based drugs from liposomal carriers enables greater control over drug delivery." @default.
- W3208623744 created "2021-11-08" @default.
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- W3208623744 date "2021-10-27" @default.
- W3208623744 modified "2023-10-15" @default.
- W3208623744 title "Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes" @default.
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- W3208623744 doi "https://doi.org/10.1002/open.202100222" @default.
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