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- W3208623909 abstract "ABSTRACT Successful interventions to prevent cerebrovascular disease and stroke require early identification of persons at risk before clinical manifestation of disease. We assessed the predictive value of biological age (BA) as an early indicator for cerebrovascular disease and risk of first-ever intracerebral hemorrhage (ICH) and cerebral infarction (CI) in advanced age and compared these relationships with commonly used biomarkers including tau and Aβ40 and Aβ42. The study included Individuals who consented for blood draw and follow-up. We computed biological age using structural equation modelling. The algorithm integrates biomarkers that represent six body systems involved in overall cerebrovascular health including metabolic function, cardiac function, lung function, kidney function, liver function, immunity and inflammation. Time to event analysis was conducted using Cox-regression models. Prediction analysis was conducted using Harrel’s C and Area under the receiver operating characteristic curve. The sample included a total of 1699 individuals at baseline followed up over a median of 11 years. During a period of 15, 780 and 16, 172 person-years a total of 17 first-ever intracerebral hemorrhage and 83 cerebral infarction cases occurred. In time-to-event analysis, BA showed higher magnitude of associations with ICH compared to CA (HR BA-ICH: 2.30, 95% CI: 1.20, 4.30; HR CA-ICH: 1.40, 95% CI: 0.76, 2.53) and higher precision with CI (HR BA-CI: 1.30, 95% CI: 1.01,1.75; HR CA-CI: 1.90, 95% CI: 1.48, 2.66). BA outperformed CA for prediction of ICH (AUC: 0.68 vs 0.53; Harrel’s C: 0.72 vs 0.53) and for CI (AUC:0.63 vs 0.62; Harrel’s C: 0.68 vs 0.67). Biological aging based on integrated physiology biomarkers provides a novel tool for monitoring and identification of persons at highest risk of cerebrovascular disease in advanced age. Future studies should confirm these observations in bigger samples and further characterize aging mechanisms that contribute towards brain reserve and resilience among individuals with similar risk profiles." @default.
- W3208623909 created "2021-11-08" @default.
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- W3208623909 date "2021-10-30" @default.
- W3208623909 modified "2023-10-06" @default.
- W3208623909 title "Biological Aging for Risk Prediction of First-Ever Intracerebral Hemorrhage and Cerebral Infarction in Advanced Age" @default.
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- W3208623909 doi "https://doi.org/10.1101/2021.10.28.21265620" @default.
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