Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208648450> ?p ?o ?g. }
- W3208648450 abstract "Progression of fibrillar tau is a key driver of dementia symptoms in Alzheimer's disease (AD), but predictors of the rate of tau accumulation at patient-level are missing. Here we combined the to-date largest number of genetic risk variants of AD (n=85 lead SNPs) from recent GWAS to generate a polygenic score (PGS) predicting the rate of change in fibrillar tau. We found that a higher PGS was associated with higher rates of PET-assessed fibrillar-tau accumulation over a mean of 1.8 yrs (range = 0.6 - 4 yrs). This, in turn, mediated the effects of the PGS on faster rates of cognitive decline. Sensitivity analysis showed that the effects were similar for men and women but pronounced in individuals with elevated levels of beta-amyloid and strongest for lead SNPs expressed in microglia. Together, our results demonstrate that the PGS predicts tau progression in Alzheimer's disease, which could afford sample size savings by up to 34% when used alone and up to 61% when combined with APOE ϵ4 genotype in clinical trials targeting tau pathology." @default.
- W3208648450 created "2021-11-08" @default.
- W3208648450 creator A5022072512 @default.
- W3208648450 creator A5031173940 @default.
- W3208648450 creator A5042997188 @default.
- W3208648450 creator A5053186566 @default.
- W3208648450 creator A5061123357 @default.
- W3208648450 creator A5078107639 @default.
- W3208648450 creator A5080142972 @default.
- W3208648450 date "2021-11-02" @default.
- W3208648450 modified "2023-09-23" @default.
- W3208648450 title "Polygenic effect on accelerated tau pathology accumulation in Alzheimer's disease: Implications for patient selection in clinical trials" @default.
- W3208648450 cites W1906409993 @default.
- W3208648450 cites W1953027527 @default.
- W3208648450 cites W2010695389 @default.
- W3208648450 cites W2021561314 @default.
- W3208648450 cites W2024719735 @default.
- W3208648450 cites W2032230738 @default.
- W3208648450 cites W2052742260 @default.
- W3208648450 cites W2069743064 @default.
- W3208648450 cites W2099085143 @default.
- W3208648450 cites W2110065044 @default.
- W3208648450 cites W2122328291 @default.
- W3208648450 cites W2124341714 @default.
- W3208648450 cites W2129598810 @default.
- W3208648450 cites W2160597466 @default.
- W3208648450 cites W2166511841 @default.
- W3208648450 cites W2170937822 @default.
- W3208648450 cites W2193207784 @default.
- W3208648450 cites W2279396572 @default.
- W3208648450 cites W2290598353 @default.
- W3208648450 cites W2301413049 @default.
- W3208648450 cites W2345958530 @default.
- W3208648450 cites W2460724252 @default.
- W3208648450 cites W2462066030 @default.
- W3208648450 cites W2465169012 @default.
- W3208648450 cites W2485069266 @default.
- W3208648450 cites W2510973425 @default.
- W3208648450 cites W2511515754 @default.
- W3208648450 cites W2560584411 @default.
- W3208648450 cites W2592518050 @default.
- W3208648450 cites W2600084629 @default.
- W3208648450 cites W2616216465 @default.
- W3208648450 cites W2621105275 @default.
- W3208648450 cites W2638580840 @default.
- W3208648450 cites W2739334724 @default.
- W3208648450 cites W2765181675 @default.
- W3208648450 cites W2789976306 @default.
- W3208648450 cites W2791135917 @default.
- W3208648450 cites W2794480084 @default.
- W3208648450 cites W2795232397 @default.
- W3208648450 cites W2802157723 @default.
- W3208648450 cites W2803332630 @default.
- W3208648450 cites W2808227793 @default.
- W3208648450 cites W2811424297 @default.
- W3208648450 cites W2884864950 @default.
- W3208648450 cites W2892024211 @default.
- W3208648450 cites W2897294494 @default.
- W3208648450 cites W2900370721 @default.
- W3208648450 cites W2904433122 @default.
- W3208648450 cites W2908002252 @default.
- W3208648450 cites W2910313823 @default.
- W3208648450 cites W2913192031 @default.
- W3208648450 cites W2914712649 @default.
- W3208648450 cites W2916749909 @default.
- W3208648450 cites W2921586060 @default.
- W3208648450 cites W2932671560 @default.
- W3208648450 cites W2939459090 @default.
- W3208648450 cites W2940298618 @default.
- W3208648450 cites W2949280410 @default.
- W3208648450 cites W2951267899 @default.
- W3208648450 cites W2963306242 @default.
- W3208648450 cites W2969948459 @default.
- W3208648450 cites W2989855650 @default.
- W3208648450 cites W2995524996 @default.
- W3208648450 cites W2996615980 @default.
- W3208648450 cites W2998707549 @default.
- W3208648450 cites W3001510487 @default.
- W3208648450 cites W3007646009 @default.
- W3208648450 cites W3010794325 @default.
- W3208648450 cites W3011085431 @default.
- W3208648450 cites W3011167359 @default.
- W3208648450 cites W3037497912 @default.
- W3208648450 cites W3037604578 @default.
- W3208648450 cites W3043145818 @default.
- W3208648450 cites W3046275966 @default.
- W3208648450 cites W3090704421 @default.
- W3208648450 cites W3092171882 @default.
- W3208648450 cites W3094551933 @default.
- W3208648450 cites W3109839649 @default.
- W3208648450 cites W3109942090 @default.
- W3208648450 cites W3119266093 @default.
- W3208648450 cites W3120777691 @default.
- W3208648450 cites W3122375100 @default.
- W3208648450 cites W3127021661 @default.
- W3208648450 cites W3134721632 @default.
- W3208648450 cites W3151279733 @default.
- W3208648450 cites W3157957864 @default.
- W3208648450 cites W3165588885 @default.
- W3208648450 cites W3172294552 @default.