Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208654462> ?p ?o ?g. }
- W3208654462 abstract "Human gastrointestinal cancer (e.g., gastric cancer and colorectal cancer) has been a leading cause of cancer-related deaths worldwide and has imposed a great threat to the public health. Although early-stage gastrointestinal cancer can be effectively treated by surgery, followed by postoperative chemotherapy, patients with advanced gastrointestinal cancer often exhibit poor prognosis and cancer relapse due to the absence of effective personalized treatment strategies. Patient-derived cancer organoid technology has been rapidly developed in recent years, and its emergence has opened up an unprecedented approach to model human cancers in vitro. Patient-derived cancer organoids involve the ex vivo culture of fragments of freshly resected human tumors that retain the histological features of original tumors. This review thoroughly discussed the evolutionary process of human gastrointestinal organoids cultured since 2009, and highlighted the potentials of patient-derived cancer organoids in clinical management of gastrointestinal cancer in terms of advances achieved in cancer modelling compared with conventional modelling methods, high-throughput drug screening, and development of personalized treatment selection. Additionally, the current limitations of patient-derived cancer organoids and the potential solutions to overcome these problems were summarized." @default.
- W3208654462 created "2021-11-08" @default.
- W3208654462 creator A5000926492 @default.
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- W3208654462 creator A5054878542 @default.
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- W3208654462 creator A5071607602 @default.
- W3208654462 creator A5075288017 @default.
- W3208654462 date "2021-10-29" @default.
- W3208654462 modified "2023-09-27" @default.
- W3208654462 title "Development and Application of Patient-Derived Cancer Organoidsin Clinical Management of Gastrointestinal Cancer: A State-of-the-Art Review" @default.
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