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- W3208656512 abstract "Previous neuroimaging studies in rodents investigated effects of the controlled cortical impact (CCI) model of traumatic brain injury (TBI) within one-month post-TBI. This study extends this temporal window to monitor the structural-functional alterations from two hours to six months post-injury. Thirty-seven male Sprague-Dawley rats were randomly assigned to TBI and sham groups, which were scanned at two hours, 1, 3, 7, 14, 30, 60 days, and six months following CCI or sham surgery. Structural MRI, diffusion tensor imaging, and resting-state functional magnetic resonance imaging were acquired to assess the dynamic structural, microstructural, and functional connectivity alterations post-TBI. There was a progressive increase in lesion size associated with brain volume loss post-TBI. Furthermore, we observed reduced fractional anisotropy within 24 h and persisted to six months post-TBI, associated with acutely reduced axial diffusivity, and chronic increases in radial diffusivity post-TBI. Moreover, a time-dependent pattern of altered functional connectivity evolved over the six months' follow-up post-TBI. This study extends the current understanding of the CCI model by confirming the long-term persistence of the altered microstructure and functional connectivity, which may hold a strong translational potential for understanding the long-term sequelae of TBI in humans." @default.
- W3208656512 created "2021-11-08" @default.
- W3208656512 creator A5044995419 @default.
- W3208656512 creator A5059442438 @default.
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- W3208656512 date "2021-11-03" @default.
- W3208656512 modified "2023-09-26" @default.
- W3208656512 title "Traumatic brain injury augurs ill for prolonged deficits in the brain’s structural and functional integrity following controlled cortical impact injury" @default.
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- W3208656512 cites W1599691548 @default.
- W3208656512 cites W1964972354 @default.
- W3208656512 cites W1972075219 @default.
- W3208656512 cites W1973831188 @default.
- W3208656512 cites W1976407450 @default.
- W3208656512 cites W1978354990 @default.
- W3208656512 cites W1983449280 @default.
- W3208656512 cites W1984737307 @default.
- W3208656512 cites W1986462650 @default.
- W3208656512 cites W1993445932 @default.
- W3208656512 cites W1998332829 @default.
- W3208656512 cites W2005401338 @default.
- W3208656512 cites W2018855952 @default.
- W3208656512 cites W2023774170 @default.
- W3208656512 cites W2027181597 @default.
- W3208656512 cites W2030787334 @default.
- W3208656512 cites W2034010692 @default.
- W3208656512 cites W2034548059 @default.
- W3208656512 cites W2041363468 @default.
- W3208656512 cites W2042933433 @default.
- W3208656512 cites W2047152236 @default.
- W3208656512 cites W2048228128 @default.
- W3208656512 cites W2056143628 @default.
- W3208656512 cites W2067451082 @default.
- W3208656512 cites W2071425128 @default.
- W3208656512 cites W2074595931 @default.
- W3208656512 cites W2075158365 @default.
- W3208656512 cites W2076750015 @default.
- W3208656512 cites W2081782337 @default.
- W3208656512 cites W2083249651 @default.
- W3208656512 cites W2085653033 @default.
- W3208656512 cites W2087412997 @default.
- W3208656512 cites W2088593782 @default.
- W3208656512 cites W2091566506 @default.
- W3208656512 cites W2096181156 @default.
- W3208656512 cites W2104695012 @default.
- W3208656512 cites W2105515629 @default.
- W3208656512 cites W2109806433 @default.
- W3208656512 cites W2112357770 @default.
- W3208656512 cites W2114099714 @default.
- W3208656512 cites W2117340355 @default.
- W3208656512 cites W2129285116 @default.
- W3208656512 cites W2131211125 @default.
- W3208656512 cites W2136404265 @default.
- W3208656512 cites W2136863044 @default.
- W3208656512 cites W2138790588 @default.
- W3208656512 cites W2142059961 @default.
- W3208656512 cites W2142855474 @default.
- W3208656512 cites W2152380947 @default.
- W3208656512 cites W2157723935 @default.
- W3208656512 cites W2166326266 @default.
- W3208656512 cites W2166894022 @default.
- W3208656512 cites W2170424940 @default.
- W3208656512 cites W2201482002 @default.
- W3208656512 cites W2293899587 @default.
- W3208656512 cites W2345939122 @default.
- W3208656512 cites W2462521170 @default.
- W3208656512 cites W2498395493 @default.
- W3208656512 cites W2517300700 @default.
- W3208656512 cites W2550693625 @default.
- W3208656512 cites W2572856951 @default.
- W3208656512 cites W2627093176 @default.
- W3208656512 cites W2768375164 @default.
- W3208656512 cites W2793575999 @default.
- W3208656512 cites W2810593900 @default.
- W3208656512 cites W2882972034 @default.
- W3208656512 cites W2884064543 @default.
- W3208656512 cites W2884467043 @default.
- W3208656512 cites W2899281562 @default.
- W3208656512 cites W2904459898 @default.
- W3208656512 cites W2915478013 @default.
- W3208656512 cites W2920979165 @default.
- W3208656512 cites W2994826704 @default.
- W3208656512 cites W3009124355 @default.
- W3208656512 cites W3158409522 @default.
- W3208656512 cites W3159327892 @default.
- W3208656512 cites W3175068450 @default.
- W3208656512 cites W4323237920 @default.
- W3208656512 doi "https://doi.org/10.1038/s41598-021-00660-5" @default.
- W3208656512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8566513" @default.
- W3208656512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34732737" @default.
- W3208656512 hasPublicationYear "2021" @default.
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