Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208669085> ?p ?o ?g. }
- W3208669085 endingPage "100436" @default.
- W3208669085 startingPage "100436" @default.
- W3208669085 abstract "Cellular morphology has the capacity to serve as a surrogate for cellular state and functionality. However, primary cardiomyocytes, the standard model in cardiovascular research, are highly heterogeneous cells and therefore impose methodological challenges to analysis. Hence, we aimed to devise a robust methodology to deconvolute cardiomyocyte morphology on a single-cell level: C-MORE (cellular morphology recognition) is a workflow from bench to data analysis tailored for heterogeneous primary cells using our R package cmoRe. We demonstrate its utility in proof-of-principle applications such as modulation of canonical hypertrophy pathways and linkage of genotype-phenotype in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In our pilot study, exposure of cardiomyocytes to blood plasma prior to versus after aortic valve replacement allows identification of a disease fingerprint and reflects partial reversibility following therapeutic intervention. C-MORE is a valuable tool for cardiovascular research with possible fields of application in basic research and personalized medicine." @default.
- W3208669085 created "2021-11-08" @default.
- W3208669085 creator A5002159498 @default.
- W3208669085 creator A5008704300 @default.
- W3208669085 creator A5025967345 @default.
- W3208669085 creator A5040825839 @default.
- W3208669085 creator A5049262839 @default.
- W3208669085 creator A5050986580 @default.
- W3208669085 creator A5058130130 @default.
- W3208669085 creator A5075116222 @default.
- W3208669085 creator A5077959685 @default.
- W3208669085 date "2021-11-01" @default.
- W3208669085 modified "2023-10-07" @default.
- W3208669085 title "C-MORE: A high-content single-cell morphology recognition methodology for liquid biopsies toward personalized cardiovascular medicine" @default.
- W3208669085 cites W1543445053 @default.
- W3208669085 cites W1818189828 @default.
- W3208669085 cites W1972321222 @default.
- W3208669085 cites W1998860713 @default.
- W3208669085 cites W2009813647 @default.
- W3208669085 cites W2026196459 @default.
- W3208669085 cites W2027082110 @default.
- W3208669085 cites W2036145275 @default.
- W3208669085 cites W2036272929 @default.
- W3208669085 cites W2044465660 @default.
- W3208669085 cites W2084563588 @default.
- W3208669085 cites W2096102365 @default.
- W3208669085 cites W2104640964 @default.
- W3208669085 cites W2107554012 @default.
- W3208669085 cites W2142634710 @default.
- W3208669085 cites W2145303230 @default.
- W3208669085 cites W2148093271 @default.
- W3208669085 cites W2150407444 @default.
- W3208669085 cites W2183389629 @default.
- W3208669085 cites W2211797036 @default.
- W3208669085 cites W2257383956 @default.
- W3208669085 cites W2415715899 @default.
- W3208669085 cites W2467851095 @default.
- W3208669085 cites W2480007569 @default.
- W3208669085 cites W2504770700 @default.
- W3208669085 cites W2594599258 @default.
- W3208669085 cites W2769605488 @default.
- W3208669085 cites W2783781232 @default.
- W3208669085 cites W2794301983 @default.
- W3208669085 cites W2799410199 @default.
- W3208669085 cites W2887850845 @default.
- W3208669085 cites W2895168260 @default.
- W3208669085 cites W2904261171 @default.
- W3208669085 cites W2907799023 @default.
- W3208669085 cites W2915458253 @default.
- W3208669085 cites W2921881805 @default.
- W3208669085 cites W3029474394 @default.
- W3208669085 cites W3088401235 @default.
- W3208669085 cites W3105146463 @default.
- W3208669085 cites W3119803061 @default.
- W3208669085 cites W3126057091 @default.
- W3208669085 cites W4212787553 @default.
- W3208669085 doi "https://doi.org/10.1016/j.xcrm.2021.100436" @default.
- W3208669085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8606902" @default.
- W3208669085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34841289" @default.
- W3208669085 hasPublicationYear "2021" @default.
- W3208669085 type Work @default.
- W3208669085 sameAs 3208669085 @default.
- W3208669085 citedByCount "4" @default.
- W3208669085 countsByYear W32086690852022 @default.
- W3208669085 countsByYear W32086690852023 @default.
- W3208669085 crossrefType "journal-article" @default.
- W3208669085 hasAuthorship W3208669085A5002159498 @default.
- W3208669085 hasAuthorship W3208669085A5008704300 @default.
- W3208669085 hasAuthorship W3208669085A5025967345 @default.
- W3208669085 hasAuthorship W3208669085A5040825839 @default.
- W3208669085 hasAuthorship W3208669085A5049262839 @default.
- W3208669085 hasAuthorship W3208669085A5050986580 @default.
- W3208669085 hasAuthorship W3208669085A5058130130 @default.
- W3208669085 hasAuthorship W3208669085A5075116222 @default.
- W3208669085 hasAuthorship W3208669085A5077959685 @default.
- W3208669085 hasBestOaLocation W32086690851 @default.
- W3208669085 hasConcept C104317684 @default.
- W3208669085 hasConcept C107459253 @default.
- W3208669085 hasConcept C10854531 @default.
- W3208669085 hasConcept C126322002 @default.
- W3208669085 hasConcept C127716648 @default.
- W3208669085 hasConcept C145103041 @default.
- W3208669085 hasConcept C1491633281 @default.
- W3208669085 hasConcept C167414201 @default.
- W3208669085 hasConcept C169760540 @default.
- W3208669085 hasConcept C177212765 @default.
- W3208669085 hasConcept C28328180 @default.
- W3208669085 hasConcept C32220436 @default.
- W3208669085 hasConcept C41008148 @default.
- W3208669085 hasConcept C54355233 @default.
- W3208669085 hasConcept C60644358 @default.
- W3208669085 hasConcept C70721500 @default.
- W3208669085 hasConcept C71924100 @default.
- W3208669085 hasConcept C77088390 @default.
- W3208669085 hasConcept C86803240 @default.
- W3208669085 hasConcept C95444343 @default.
- W3208669085 hasConceptScore W3208669085C104317684 @default.
- W3208669085 hasConceptScore W3208669085C107459253 @default.