FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208673919> ?p ?o ?g. }

• W3208673919 endingPage "100990" @default.
• W3208673919 startingPage "100990" @default.
• W3208673919 abstract "Coronavirus disease 2019 is characterized by the elevation of a broad spectrum of inflammatory mediators associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors (TF) for these inflammatory genes that may help to devise potential therapeutic strategies in the future.The cytokine regulating immune-expressed genes (CRIEG) were sorted from literature and the GEO microarray dataset. Their co-differentially expressed miRNA and transcription factors were predicted from publicly available databases. Enrichment analysis was done through mienturnet, MiEAA, Gene Ontology, and pathways predicted by KEGG and Reactome pathways. Finally, the functional and regulatory features were analyzed and visualized through Cytoscape.Sixteen CRIEG were observed to have a significant protein-protein interaction network. The ontological analysis revealed significantly enriched pathways for biological processes, molecular functions, and cellular components. The search performed in the miRNA database yielded ten miRNAs that are significantly involved in regulating these genes and their transcription factors.An in-silico representation of a network involving miRNAs, CRIEGs, and TF, which take part in the inflammatory response in COVID-19, has been elucidated. Thus, these regulatory factors may have potentially critical roles in the inflammatory response in COVID-19 and may be explored further to develop targeted therapeutic strategies and mechanistic validation." @default.
• W3208673919 created "2021-11-08" @default.
• W3208673919 creator A5010796207 @default.
• W3208673919 creator A5021680655 @default.
• W3208673919 creator A5076472506 @default.
• W3208673919 date "2022-02-01" @default.
• W3208673919 modified "2023-09-26" @default.
• W3208673919 title "MicroRNAs based regulation of cytokine regulating immune expressed genes and their transcription factors in COVID-19" @default.
• W3208673919 cites W1578530056 @default.
• W3208673919 cites W1900169622 @default.
• W3208673919 cites W2058008662 @default.
• W3208673919 cites W2060468039 @default.
• W3208673919 cites W2114025547 @default.
• W3208673919 cites W2114940961 @default.
• W3208673919 cites W2118105142 @default.
• W3208673919 cites W2132093971 @default.
• W3208673919 cites W2134193049 @default.
• W3208673919 cites W2153863419 @default.
• W3208673919 cites W2159675211 @default.
• W3208673919 cites W2181772832 @default.
• W3208673919 cites W2468616940 @default.
• W3208673919 cites W2508381005 @default.
• W3208673919 cites W2568767065 @default.
• W3208673919 cites W2576828777 @default.
• W3208673919 cites W2584846957 @default.
• W3208673919 cites W2748577514 @default.
• W3208673919 cites W2770049589 @default.
• W3208673919 cites W2800797190 @default.
• W3208673919 cites W2906329576 @default.
• W3208673919 cites W2908714372 @default.
• W3208673919 cites W2911739685 @default.
• W3208673919 cites W2917971614 @default.
• W3208673919 cites W2938480747 @default.
• W3208673919 cites W2950470413 @default.
• W3208673919 cites W2970534831 @default.
• W3208673919 cites W2977536460 @default.
• W3208673919 cites W2987179243 @default.
• W3208673919 cites W3001118548 @default.
• W3208673919 cites W3008090866 @default.
• W3208673919 cites W3008420046 @default.
• W3208673919 cites W3009314935 @default.
• W3208673919 cites W3009885589 @default.
• W3208673919 cites W3012421327 @default.
• W3208673919 cites W3012909412 @default.
• W3208673919 cites W3012947778 @default.
• W3208673919 cites W3013270782 @default.
• W3208673919 cites W3013843138 @default.
• W3208673919 cites W3014003872 @default.
• W3208673919 cites W3016489853 @default.
• W3208673919 cites W3020710323 @default.
• W3208673919 cites W3021526350 @default.
• W3208673919 cites W3022967842 @default.
• W3208673919 cites W3023862871 @default.
• W3208673919 cites W3024193040 @default.
• W3208673919 cites W3029717128 @default.
• W3208673919 cites W3031446229 @default.
• W3208673919 cites W3033005856 @default.
• W3208673919 cites W3034095150 @default.
• W3208673919 cites W3034708975 @default.
• W3208673919 cites W3034785821 @default.
• W3208673919 cites W3035802734 @default.
• W3208673919 cites W3039456903 @default.
• W3208673919 cites W3041960835 @default.
• W3208673919 cites W3042494210 @default.
• W3208673919 cites W3043831218 @default.
• W3208673919 cites W3048433377 @default.
• W3208673919 cites W3080149237 @default.
• W3208673919 cites W3082347883 @default.
• W3208673919 cites W3084085407 @default.
• W3208673919 cites W3092325443 @default.
• W3208673919 cites W3108150708 @default.
• W3208673919 cites W3109754638 @default.
• W3208673919 cites W3112004344 @default.
• W3208673919 cites W3119446940 @default.
• W3208673919 cites W3139026142 @default.
• W3208673919 cites W3156243456 @default.
• W3208673919 cites W3165656738 @default.
• W3208673919 cites W2988009864 @default.
• W3208673919 doi "https://doi.org/10.1016/j.mgene.2021.100990" @default.
• W3208673919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8547816" @default.
• W3208673919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34722158" @default.
• W3208673919 hasPublicationYear "2022" @default.
• W3208673919 type Work @default.
• W3208673919 sameAs 3208673919 @default.
• W3208673919 citedByCount "17" @default.
• W3208673919 countsByYear W32086739192022 @default.
• W3208673919 countsByYear W32086739192023 @default.
• W3208673919 crossrefType "journal-article" @default.
• W3208673919 hasAuthorship W3208673919A5010796207 @default.
• W3208673919 hasAuthorship W3208673919A5021680655 @default.
• W3208673919 hasAuthorship W3208673919A5076472506 @default.
• W3208673919 hasBestOaLocation W32086739191 @default.
• W3208673919 hasConcept C104317684 @default.
• W3208673919 hasConcept C145059251 @default.
• W3208673919 hasConcept C150194340 @default.
• W3208673919 hasConcept C152724338 @default.
• W3208673919 hasConcept C165864922 @default.
• W3208673919 hasConcept C186836561 @default.

• next