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- W3208696111 abstract "Objective: To investigate the characteristics of glutamatergic neurotransmitter and neurotransmission dysfunction in patients with major depressive disorder (MDD) and its relationship with clinical characteristics. Methods: Fifty-two patients with MDD and 51 healthy controls were selected. Hamilton Depression scale-17 (HAMD-17) and Hamilton Anxiety Scale (HAMA) were used to evaluate the symptoms of depression and anxiety. The serum glutamate level was measured by enzyme-linked immunosorbent assay (ELISA). Reverse transcription polymerase chain reaction (RT-PCR) was used to detect the mRNA level of NR1 subunit of NMDA receptor. Results: There was no significant difference in gender and age between MDD group and healthy control group. Compared with the control group, the level of serum glutamate [(35±6) mg/L vs (29±6) mg/L, P = 0.021] and mRNA level of NR1 (1.5±0.8 vs 0.8±0.6, P = 0.001) in MDD group were significantly higher. In MDD group, serum glutamate level was positively correlated with depression core symptom score (r = 0.52, P = 0.028), and mRNA level of NR1 subunit was positively correlated with the total course of disease (r = 0.42, P = 0.024). Conclusion: MDD patients may have disorder of glutamatergic neurotransmitter and abnormal expression of NR1 subunit.目的： 探讨重性抑郁症（MDD）患者谷氨酸能神经递质与神经传递功能紊乱特点及其与临床特征的关系。 方法： 选取2019年8月至2020年8月在暨南大学附属第一医院就诊的MDD患者52例，社区招募健康对照51名，以汉密尔顿抑郁量表（HAMD-17）、汉密尔顿焦虑量表（HAMA）评估被试抑郁、焦虑症状，以酶联免疫吸附法测定血清谷氨酸水平，以逆转录聚合酶链反应检测NMDA受体NR1亚基mRNA水平。 结果： MDD组与健康对照组间性别、年龄差异无统计学意义（P>0.05）；MDD组血清谷氨酸水平［（35±6）mg/L 比（29±6）mg/L， P=0.021］及血液NR1亚基mRNA水平（1.5±0.8比0.8±0.6，P=0.001）高于健康对照组。MDD组血清谷氨酸水平与抑郁核心症状分呈正相关（r=0.52，P=0.028），NR1亚基mRNA水平与总病程呈正相关（r=0.42，P=0.024）。 结论： MDD可能存在谷氨酸能神经递质水平紊乱及NR1亚基表达异常。." @default.
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- W3208696111 date "2021-10-26" @default.
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- W3208696111 title "[mRNA level of N-methyl-D-aspartic acid receptor NR1 subunit in patients with major depressive disorder and its relationship with clinical features]." @default.
- W3208696111 doi "https://doi.org/10.3760/cma.j.cn112137-20210306-00573" @default.
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