Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208698931> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3208698931 abstract "<h3>Objectives</h3> Undifferentiated and dedifferentiated endometrial carcinomas (UEC/DDEC) are rare, high grade, and have only been increasingly recognized within the past decade. Studies of their behavior and response to adjuvant to guide prognostication and management are limited. We present the management experience of a single institution. <h3>Methods</h3> Using the Juravinski Hospital electronic medical record, we identified all patients with UEC or DDEC treated at our institution from January 2005-December 2020. Clinical information was obtained by chart review. <h3>Results</h3> We identified 35 patients with UEC/DDEC; 15 UEC, 20 DDEC. Mean age was 66 years. Only 25.1% had preoperative endometrial biopsy concordant with final pathology despite 87.5% review by gynecologic pathologists. Stage distribution was 37.1% stage I, 14.3% stage II, 14.3% stage III, 34.3% stage IV. 7/33 (21.2%) had gross residual after surgery; 4 received adjuvant carboplatin-paclitaxel chemotherapy with 2 progressions, 1 partial response and 1 complete response (ORR 50%). Mean PFS was 11.7±9.3 months. Fifteen patients had progressive or recurrent disease—of these, 4 were treated with radiation, 3 with chemotherapy (adriamycin, carboplatin-paclitaxel, doxorubicin), and all 7 progressed on treatment. The most common site of recurrence was widely disseminated disease (54.5%), followed by nodal (18.2%) and chest (18.2%). Mean OS was as follows by stage: stage I-II completely resected, 43 months; stage III completely resected, 19 months; stage IV, suboptimally debulked or inoperable, 20 months. <h3>Conclusions</h3> UEC/DDEC are aggressive tumours with poor prognoses and remain challenging to diagnose on preoperative biopsy. Platinum-based adjuvant chemotherapy may have some efficacy, however, recurrences respond poorly to salvage." @default.
- W3208698931 created "2021-11-08" @default.
- W3208698931 creator A5001149898 @default.
- W3208698931 creator A5008249016 @default.
- W3208698931 creator A5025320662 @default.
- W3208698931 creator A5033721592 @default.
- W3208698931 creator A5039497051 @default.
- W3208698931 creator A5048927518 @default.
- W3208698931 creator A5050339301 @default.
- W3208698931 creator A5052622738 @default.
- W3208698931 creator A5057116852 @default.
- W3208698931 creator A5061853040 @default.
- W3208698931 creator A5067411692 @default.
- W3208698931 creator A5082849225 @default.
- W3208698931 creator A5085438320 @default.
- W3208698931 date "2021-11-01" @default.
- W3208698931 modified "2023-09-27" @default.
- W3208698931 title "EPV126/#448 Undifferentiated and dedifferentiated carcinoma of the endometrium: clinicopathologic features and implications for prognostication and management" @default.
- W3208698931 doi "https://doi.org/10.1136/ijgc-2021-igcs.196" @default.
- W3208698931 hasPublicationYear "2021" @default.
- W3208698931 type Work @default.
- W3208698931 sameAs 3208698931 @default.
- W3208698931 citedByCount "0" @default.
- W3208698931 crossrefType "proceedings-article" @default.
- W3208698931 hasAuthorship W3208698931A5001149898 @default.
- W3208698931 hasAuthorship W3208698931A5008249016 @default.
- W3208698931 hasAuthorship W3208698931A5025320662 @default.
- W3208698931 hasAuthorship W3208698931A5033721592 @default.
- W3208698931 hasAuthorship W3208698931A5039497051 @default.
- W3208698931 hasAuthorship W3208698931A5048927518 @default.
- W3208698931 hasAuthorship W3208698931A5050339301 @default.
- W3208698931 hasAuthorship W3208698931A5052622738 @default.
- W3208698931 hasAuthorship W3208698931A5057116852 @default.
- W3208698931 hasAuthorship W3208698931A5061853040 @default.
- W3208698931 hasAuthorship W3208698931A5067411692 @default.
- W3208698931 hasAuthorship W3208698931A5082849225 @default.
- W3208698931 hasAuthorship W3208698931A5085438320 @default.
- W3208698931 hasBestOaLocation W32086989311 @default.
- W3208698931 hasConcept C126322002 @default.
- W3208698931 hasConcept C126838900 @default.
- W3208698931 hasConcept C141071460 @default.
- W3208698931 hasConcept C143998085 @default.
- W3208698931 hasConcept C146357865 @default.
- W3208698931 hasConcept C151730666 @default.
- W3208698931 hasConcept C2776694085 @default.
- W3208698931 hasConcept C2778239845 @default.
- W3208698931 hasConcept C2781451048 @default.
- W3208698931 hasConcept C509974204 @default.
- W3208698931 hasConcept C71924100 @default.
- W3208698931 hasConcept C86803240 @default.
- W3208698931 hasConceptScore W3208698931C126322002 @default.
- W3208698931 hasConceptScore W3208698931C126838900 @default.
- W3208698931 hasConceptScore W3208698931C141071460 @default.
- W3208698931 hasConceptScore W3208698931C143998085 @default.
- W3208698931 hasConceptScore W3208698931C146357865 @default.
- W3208698931 hasConceptScore W3208698931C151730666 @default.
- W3208698931 hasConceptScore W3208698931C2776694085 @default.
- W3208698931 hasConceptScore W3208698931C2778239845 @default.
- W3208698931 hasConceptScore W3208698931C2781451048 @default.
- W3208698931 hasConceptScore W3208698931C509974204 @default.
- W3208698931 hasConceptScore W3208698931C71924100 @default.
- W3208698931 hasConceptScore W3208698931C86803240 @default.
- W3208698931 hasLocation W32086989311 @default.
- W3208698931 hasOpenAccess W3208698931 @default.
- W3208698931 hasPrimaryLocation W32086989311 @default.
- W3208698931 hasRelatedWork W2029688276 @default.
- W3208698931 hasRelatedWork W2049284535 @default.
- W3208698931 hasRelatedWork W2053778437 @default.
- W3208698931 hasRelatedWork W2072767112 @default.
- W3208698931 hasRelatedWork W2074080783 @default.
- W3208698931 hasRelatedWork W2348495938 @default.
- W3208698931 hasRelatedWork W2460868461 @default.
- W3208698931 hasRelatedWork W2461744023 @default.
- W3208698931 hasRelatedWork W2510176483 @default.
- W3208698931 hasRelatedWork W2510670462 @default.
- W3208698931 isParatext "false" @default.
- W3208698931 isRetracted "false" @default.
- W3208698931 magId "3208698931" @default.
- W3208698931 workType "article" @default.