FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208704669> ?p ?o ?g. }

• W3208704669 endingPage "e728" @default.
• W3208704669 startingPage "e719" @default.
• W3208704669 abstract "The Spindle Assembly Checkpoint (SAC) is a surveillance mechanism essential to ensure the accuracy of chromosome segregation during mitosis. Our aim was to evaluate the expression of SAC proteins in oral carcinogenesis, and to assess their potential in predicting malignant transformation of oral leukoplakia.We analysed the immunoexpression of BubR1, Mad2, Bub3, and Spindly proteins in 64 oral biopsies from 52 oral leukoplakias and 12 normal tissues. Univariate and multivariate analysis were performed to evaluate predictive factors for malignant transformation (MT).We observed that BubR1 and Mad2 were more highly expressed in high dysplasia grade lesions than in low grade or normal tissues (P<0.05). High expression of Spindly was significantly correlated with a high Ki-67 score (P=0.004). Six (11.5%) oral leukoplakias underwent malignant transformation. In univariate analysis, the binary dysplasia grade (high grade) (P<0.001) was associated with a higher risk of malignant transformation as well as high BubR1 (P<0.001) and high Mad2 (P=0.013) expression. In multivariate analysis, high expression of BubR1 and Mad2 when combined showed an increased risk for malignant transformation (P=0.013; HR of 4.6, 95% CI of 1.4-15.1).Our findings reveal that BubR1 and Mad2 were associated with an increased risk for malignant transformation independently of histological grade and could be potential and useful predictive risk markers of malignant transformation in oral leukoplakias." @default.
• W3208704669 created "2021-11-08" @default.
• W3208704669 creator A5000059199 @default.
• W3208704669 creator A5010579749 @default.
• W3208704669 creator A5014704164 @default.
• W3208704669 creator A5015809574 @default.
• W3208704669 creator A5019215930 @default.
• W3208704669 creator A5021521173 @default.
• W3208704669 creator A5035262852 @default.
• W3208704669 creator A5039571952 @default.
• W3208704669 creator A5082800588 @default.
• W3208704669 creator A5088652438 @default.
• W3208704669 date "2021-01-01" @default.
• W3208704669 modified "2023-10-06" @default.
• W3208704669 title "Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study" @default.
• W3208704669 cites W1536672939 @default.
• W3208704669 cites W1894696515 @default.
• W3208704669 cites W1971886874 @default.
• W3208704669 cites W1974002397 @default.
• W3208704669 cites W1985862776 @default.
• W3208704669 cites W2016081624 @default.
• W3208704669 cites W2020047273 @default.
• W3208704669 cites W2022719826 @default.
• W3208704669 cites W2029762417 @default.
• W3208704669 cites W2045897698 @default.
• W3208704669 cites W2071479814 @default.
• W3208704669 cites W2115344681 @default.
• W3208704669 cites W2117692326 @default.
• W3208704669 cites W2141426686 @default.
• W3208704669 cites W2142919879 @default.
• W3208704669 cites W2169436554 @default.
• W3208704669 cites W2340947246 @default.
• W3208704669 cites W2592748952 @default.
• W3208704669 cites W2739471098 @default.
• W3208704669 cites W2776152832 @default.
• W3208704669 cites W2802486554 @default.
• W3208704669 cites W2885455901 @default.
• W3208704669 cites W2922320608 @default.
• W3208704669 cites W2947841111 @default.
• W3208704669 cites W2973887189 @default.
• W3208704669 cites W2996689501 @default.
• W3208704669 cites W3002834433 @default.
• W3208704669 cites W3049520952 @default.
• W3208704669 cites W3095906787 @default.
• W3208704669 cites W3112949332 @default.
• W3208704669 doi "https://doi.org/10.4317/medoral.24511" @default.
• W3208704669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8601638" @default.
• W3208704669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34704983" @default.
• W3208704669 hasPublicationYear "2021" @default.
• W3208704669 type Work @default.
• W3208704669 sameAs 3208704669 @default.
• W3208704669 citedByCount "3" @default.
• W3208704669 countsByYear W32087046692022 @default.
• W3208704669 countsByYear W32087046692023 @default.
• W3208704669 crossrefType "journal-article" @default.
• W3208704669 hasAuthorship W3208704669A5000059199 @default.
• W3208704669 hasAuthorship W3208704669A5010579749 @default.
• W3208704669 hasAuthorship W3208704669A5014704164 @default.
• W3208704669 hasAuthorship W3208704669A5015809574 @default.
• W3208704669 hasAuthorship W3208704669A5019215930 @default.
• W3208704669 hasAuthorship W3208704669A5021521173 @default.
• W3208704669 hasAuthorship W3208704669A5035262852 @default.
• W3208704669 hasAuthorship W3208704669A5039571952 @default.
• W3208704669 hasAuthorship W3208704669A5082800588 @default.
• W3208704669 hasAuthorship W3208704669A5088652438 @default.
• W3208704669 hasBestOaLocation W32087046691 @default.
• W3208704669 hasConcept C104317684 @default.
• W3208704669 hasConcept C105696609 @default.
• W3208704669 hasConcept C121608353 @default.
• W3208704669 hasConcept C126322002 @default.
• W3208704669 hasConcept C142724271 @default.
• W3208704669 hasConcept C143998085 @default.
• W3208704669 hasConcept C144301174 @default.
• W3208704669 hasConcept C175732170 @default.
• W3208704669 hasConcept C192838845 @default.
• W3208704669 hasConcept C2775894508 @default.
• W3208704669 hasConcept C2777563682 @default.
• W3208704669 hasConcept C29537977 @default.
• W3208704669 hasConcept C30481170 @default.
• W3208704669 hasConcept C31033888 @default.
• W3208704669 hasConcept C38180746 @default.
• W3208704669 hasConcept C502942594 @default.
• W3208704669 hasConcept C54355233 @default.
• W3208704669 hasConcept C71924100 @default.
• W3208704669 hasConcept C86803240 @default.
• W3208704669 hasConceptScore W3208704669C104317684 @default.
• W3208704669 hasConceptScore W3208704669C105696609 @default.
• W3208704669 hasConceptScore W3208704669C121608353 @default.
• W3208704669 hasConceptScore W3208704669C126322002 @default.
• W3208704669 hasConceptScore W3208704669C142724271 @default.
• W3208704669 hasConceptScore W3208704669C143998085 @default.
• W3208704669 hasConceptScore W3208704669C144301174 @default.
• W3208704669 hasConceptScore W3208704669C175732170 @default.
• W3208704669 hasConceptScore W3208704669C192838845 @default.
• W3208704669 hasConceptScore W3208704669C2775894508 @default.
• W3208704669 hasConceptScore W3208704669C2777563682 @default.
• W3208704669 hasConceptScore W3208704669C29537977 @default.
• W3208704669 hasConceptScore W3208704669C30481170 @default.

• next