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- W3208707312 abstract "Carbonic anhydrase IX (CA-IX) is an endogenous marker for hypoxia and is regulated by the von Hippel-Lindau/hypoxia-inducible factor (VHL/HIF) oxygen-sensing pathway. CA-IX is overexpressed in many solid malignancies where aberrant vasculature and limited perfusion create low oxygen niches within the tumor microenvironment. Dysregulation of the VHL/HIF signaling pathway can lead to constitutive expression of CA-IX—a phenotype associated with clear cell renal cell carcinomas (ccRCCs). As a cell-surface metalloenzyme, CA-IX works in tandem with other proteins to regulate intracellular pH in response to hypoxia-induced metabolism. In recent years, there has been evidence implicating CA-IX in potentiating cancer invasion and metastasis. Accordingly, the inhibition of CA-IX catalytic activity represents an attractive option for the management of ccRCC and other solid tumors. In this chapter, we discuss the development of CA-IX radiopharmaceuticals and their roles in delineating tumoral CA-IX expression through imaging in preclinical and clinical settings. We will also review agents that have been repositioned as endoradiotherapeutic agents for theranostic application." @default.
- W3208707312 created "2021-11-08" @default.
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- W3208707312 date "2021-01-01" @default.
- W3208707312 modified "2023-09-26" @default.
- W3208707312 title "Targeting Carbonic Anhydrase IX in Tumor Imaging and Theranostic Cancer Therapy" @default.
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- W3208707312 doi "https://doi.org/10.1007/978-3-030-79511-5_12" @default.
- W3208707312 hasPublicationYear "2021" @default.
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