Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208723974> ?p ?o ?g. }
- W3208723974 abstract "Recently, large-scale human genetics studies identified a rare coding variant in the ABI3 gene that is associated with an increased risk of Alzheimer’s disease (AD). However, pathways by which ABI3 contributes to the pathogenesis of AD are unknown. To address this question, we determined whether loss of ABI3 function affects pathological features of AD in the 5XFAD mouse model. We demonstrate that the deletion of Abi3 locus significantly increases amyloid β (Aβ) accumulation and decreases microglia clustering around the plaques. Furthermore, long-term potentiation is impaired in 5XFAD;Abi3 knockout (“Abi3−/−”) mice. Moreover, we identified marked changes in the proportion of microglia subpopulations in Abi3−/− mice using a single-cell RNA sequencing approach. Mechanistic studies demonstrate that Abi3 knockdown in microglia impairs migration and phagocytosis. Together, our study provides the first in vivo functional evidence that loss of ABI3 function may increase the risk of developing AD by affecting Aβ accumulation and neuroinflammation." @default.
- W3208723974 created "2021-11-08" @default.
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- W3208723974 date "2021-11-05" @default.
- W3208723974 modified "2023-09-25" @default.
- W3208723974 title "Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis" @default.
- W3208723974 cites W1463939286 @default.
- W3208723974 cites W1488440012 @default.
- W3208723974 cites W1585782290 @default.
- W3208723974 cites W1780440403 @default.
- W3208723974 cites W1836878162 @default.
- W3208723974 cites W1887402735 @default.
- W3208723974 cites W1905136210 @default.
- W3208723974 cites W1960862471 @default.
- W3208723974 cites W1969828537 @default.
- W3208723974 cites W1981117587 @default.
- W3208723974 cites W1991763618 @default.
- W3208723974 cites W1991950590 @default.
- W3208723974 cites W1992281627 @default.
- W3208723974 cites W1994707167 @default.
- W3208723974 cites W1996024251 @default.
- W3208723974 cites W2002670780 @default.
- W3208723974 cites W2003674452 @default.
- W3208723974 cites W2004171291 @default.
- W3208723974 cites W2011041653 @default.
- W3208723974 cites W2021766416 @default.
- W3208723974 cites W2022986204 @default.
- W3208723974 cites W2062084653 @default.
- W3208723974 cites W2069089843 @default.
- W3208723974 cites W2069356387 @default.
- W3208723974 cites W207124143 @default.
- W3208723974 cites W2071625408 @default.
- W3208723974 cites W2082429191 @default.
- W3208723974 cites W2107986249 @default.
- W3208723974 cites W2118822739 @default.
- W3208723974 cites W2123047934 @default.
- W3208723974 cites W2126402425 @default.
- W3208723974 cites W2134526812 @default.
- W3208723974 cites W2137860879 @default.
- W3208723974 cites W2138745251 @default.
- W3208723974 cites W2140139281 @default.
- W3208723974 cites W2149650428 @default.
- W3208723974 cites W2154271762 @default.
- W3208723974 cites W2155344647 @default.
- W3208723974 cites W2158143414 @default.
- W3208723974 cites W2167279371 @default.
- W3208723974 cites W2167754585 @default.
- W3208723974 cites W2168334242 @default.
- W3208723974 cites W2169456326 @default.
- W3208723974 cites W2170644095 @default.
- W3208723974 cites W2177820706 @default.
- W3208723974 cites W2299031235 @default.
- W3208723974 cites W2339534121 @default.
- W3208723974 cites W2408084759 @default.
- W3208723974 cites W2556899666 @default.
- W3208723974 cites W2592518050 @default.
- W3208723974 cites W2612288104 @default.
- W3208723974 cites W2617693460 @default.
- W3208723974 cites W2622807556 @default.
- W3208723974 cites W2733874486 @default.
- W3208723974 cites W2751088224 @default.
- W3208723974 cites W2762506555 @default.
- W3208723974 cites W2762857072 @default.
- W3208723974 cites W2770258404 @default.
- W3208723974 cites W2774657197 @default.
- W3208723974 cites W2788348358 @default.
- W3208723974 cites W2790983771 @default.
- W3208723974 cites W2803478714 @default.
- W3208723974 cites W2808735182 @default.
- W3208723974 cites W2811106513 @default.
- W3208723974 cites W2885498250 @default.
- W3208723974 cites W2890187093 @default.
- W3208723974 cites W2890627020 @default.
- W3208723974 cites W2896393831 @default.
- W3208723974 cites W2898432193 @default.
- W3208723974 cites W2948343247 @default.
- W3208723974 cites W2949996247 @default.
- W3208723974 cites W2976163884 @default.
- W3208723974 cites W2998763810 @default.
- W3208723974 cites W2998795963 @default.
- W3208723974 cites W3000035810 @default.
- W3208723974 cites W3003126983 @default.
- W3208723974 cites W3082995946 @default.
- W3208723974 cites W3104184392 @default.
- W3208723974 cites W4206037526 @default.