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• W3208775257 abstract "Bone metastasis is commonly seen in patients with breast cancer, prostate cancer and lung cancer. Tumor-intrinsic factors and the tumor microenvironment cooperate to affect the formation of bone metastatic niche. Within the bone microenvironment, immune cells have been regarded as a major contributor to metastatic progression. In this review, we describe the dynamic roles of immune cells in regulating metastatic homing, seeding, dormancy, and outgrowth in the bone. We also summarize the diverse functions of immune molecules including chemokines, cytokines, and exosomes in remodeling the bone metastatic niche. Furthermore, we discuss the therapeutic and prognostic potential of these cellular and molecular players in bone metastasis." @default.
• W3208775257 created "2021-11-08" @default.
• W3208775257 creator A5019663108 @default.
• W3208775257 creator A5058391979 @default.
• W3208775257 date "2021-10-20" @default.
• W3208775257 modified "2023-10-16" @default.
• W3208775257 title "Immune Modulation of Metastatic Niche Formation in the Bone" @default.
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• W3208775257 doi "https://doi.org/10.3389/fimmu.2021.765994" @default.
• W3208775257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8564379" @default.
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• W3208775257 hasPublicationYear "2021" @default.
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