Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208778082> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3208778082 endingPage "706" @default.
- W3208778082 startingPage "694" @default.
- W3208778082 abstract "The high failure rate of the new drug development has been well recognized. Relying on the pre-clinical data obtained from animal experiments will inevitably cause a low concordance with human clinical trials, which will eventually lead to new drug development failure. Employing human induced pluripotent stem cells (iPSCs) or adult stem cells to simulate disease models can not only provide an unlimited cell materials, but also faithfully represent the genetic background of a certain disease, when iPSCs or adult stem cells derived from patients with a specific disease genetic variation are applied. In addition, gene editing methods can be used to introduce genetic variants of interest into stem cells to generate disease models. Furthermore, by establishing a cell bank with a population of iPSCs in petri dish, in vitro human genetic studies can be carried out in these cells, with GWAS and QTL studies applied to identify genetic variants that are associated with drug sensitivity or cytotoxicity. These efforts may offer valuable information for the recruitment of suitable patients for clinical trials. Therefore, stem cell-derived disease models can provide valuable resources for the pathophysiological studies of diseases as well as the drug development. In this review, we will briefly introduce the development of the liver disease models derived from stem cells and their applications in disease study and drug development." @default.
- W3208778082 created "2021-11-08" @default.
- W3208778082 creator A5033810524 @default.
- W3208778082 creator A5061084605 @default.
- W3208778082 creator A5064192486 @default.
- W3208778082 date "2021-10-25" @default.
- W3208778082 modified "2023-09-25" @default.
- W3208778082 title "Applications of stem cell disease models in liver metabolic research and drug development" @default.
- W3208778082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34708227" @default.
- W3208778082 hasPublicationYear "2021" @default.
- W3208778082 type Work @default.
- W3208778082 sameAs 3208778082 @default.
- W3208778082 citedByCount "0" @default.
- W3208778082 crossrefType "journal-article" @default.
- W3208778082 hasAuthorship W3208778082A5033810524 @default.
- W3208778082 hasAuthorship W3208778082A5061084605 @default.
- W3208778082 hasAuthorship W3208778082A5064192486 @default.
- W3208778082 hasConcept C104317684 @default.
- W3208778082 hasConcept C107459253 @default.
- W3208778082 hasConcept C142724271 @default.
- W3208778082 hasConcept C145103041 @default.
- W3208778082 hasConcept C2779134260 @default.
- W3208778082 hasConcept C2780035454 @default.
- W3208778082 hasConcept C28328180 @default.
- W3208778082 hasConcept C2908647359 @default.
- W3208778082 hasConcept C535046627 @default.
- W3208778082 hasConcept C54355233 @default.
- W3208778082 hasConcept C60644358 @default.
- W3208778082 hasConcept C64903051 @default.
- W3208778082 hasConcept C70721500 @default.
- W3208778082 hasConcept C71924100 @default.
- W3208778082 hasConcept C74187038 @default.
- W3208778082 hasConcept C86803240 @default.
- W3208778082 hasConcept C98274493 @default.
- W3208778082 hasConcept C99454951 @default.
- W3208778082 hasConceptScore W3208778082C104317684 @default.
- W3208778082 hasConceptScore W3208778082C107459253 @default.
- W3208778082 hasConceptScore W3208778082C142724271 @default.
- W3208778082 hasConceptScore W3208778082C145103041 @default.
- W3208778082 hasConceptScore W3208778082C2779134260 @default.
- W3208778082 hasConceptScore W3208778082C2780035454 @default.
- W3208778082 hasConceptScore W3208778082C28328180 @default.
- W3208778082 hasConceptScore W3208778082C2908647359 @default.
- W3208778082 hasConceptScore W3208778082C535046627 @default.
- W3208778082 hasConceptScore W3208778082C54355233 @default.
- W3208778082 hasConceptScore W3208778082C60644358 @default.
- W3208778082 hasConceptScore W3208778082C64903051 @default.
- W3208778082 hasConceptScore W3208778082C70721500 @default.
- W3208778082 hasConceptScore W3208778082C71924100 @default.
- W3208778082 hasConceptScore W3208778082C74187038 @default.
- W3208778082 hasConceptScore W3208778082C86803240 @default.
- W3208778082 hasConceptScore W3208778082C98274493 @default.
- W3208778082 hasConceptScore W3208778082C99454951 @default.
- W3208778082 hasIssue "5" @default.
- W3208778082 hasLocation W32087780821 @default.
- W3208778082 hasOpenAccess W3208778082 @default.
- W3208778082 hasPrimaryLocation W32087780821 @default.
- W3208778082 hasRelatedWork W1215705476 @default.
- W3208778082 hasRelatedWork W1485893307 @default.
- W3208778082 hasRelatedWork W1983189453 @default.
- W3208778082 hasRelatedWork W1995959676 @default.
- W3208778082 hasRelatedWork W2007334806 @default.
- W3208778082 hasRelatedWork W2043394140 @default.
- W3208778082 hasRelatedWork W2065561114 @default.
- W3208778082 hasRelatedWork W2074100108 @default.
- W3208778082 hasRelatedWork W2076111775 @default.
- W3208778082 hasRelatedWork W2081331532 @default.
- W3208778082 hasRelatedWork W2087961523 @default.
- W3208778082 hasRelatedWork W2118370783 @default.
- W3208778082 hasRelatedWork W2133369008 @default.
- W3208778082 hasRelatedWork W2143445671 @default.
- W3208778082 hasRelatedWork W2279554517 @default.
- W3208778082 hasRelatedWork W2782837010 @default.
- W3208778082 hasRelatedWork W2909467817 @default.
- W3208778082 hasRelatedWork W2920816178 @default.
- W3208778082 hasRelatedWork W2982341188 @default.
- W3208778082 hasRelatedWork W3006683993 @default.
- W3208778082 hasVolume "73" @default.
- W3208778082 isParatext "false" @default.
- W3208778082 isRetracted "false" @default.
- W3208778082 magId "3208778082" @default.
- W3208778082 workType "article" @default.