FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208784609> ?p ?o ?g. }

• W3208784609 abstract "Abstract Background: One of the main goals of microbiome research is to identify bacterial members that significantly affect host phenotypes and understand their contributions to disease pathogenesis. Studies identifying bacterial members that dictate host phenotype have focused mainly on the dominant members, and the role of low abundance microbes in determining host phenotypes and pathogenesis of diseases remains unexplored. In this study, we compared the gut bacterial community of mice with wide-ranging microbial exposure to determine if low abundance bacteria vary based on microbial exposure or remain consistent. Results: We noted that similar to the high abundance bacterial community, a core community of low abundance bacteria made up a significant portion of the gut microbiome irrespective of microbial exposure. To determine the effect of low abundance bacteria on community structure and host gene expression, we devised a microbiome dilution strategy to “delete” out low abundance bacteria and engrafted the diluted microbiomes into germ-free mice. Our approach successfully excluded low abundance bacteria from small and large intestinal bacterial communities and induced global changes in microbial community structure and composition in the large intestine. Gene expression analysis of intestinal tissue revealed that loss of low abundance bacteria resulted in a drastic reduction in expression of multiple genes involved MHC class II antigen presentation pathway and T-cell cytokine production in the small intestine. The effect of low abundance bacteria on MHC class II expression was found specific to the intestinal epithelium at an early timepoint post-colonization and correlated with bacteria belonging to the family Erysipelotrichaceae. Conclusions: We conclude that low abundance bacteria have a significantly higher immuno-stimulatory effect compared to dominant bacteria and are thus potent drivers of early immune education in the gut. Therefore, characterizing immune interaction of low abundance bacteria with the host will offer greater insight into the intestinal immune landscape and disease pathogenesis.Keywords: Gut microbiome, Low abundance bacteria, Immune education, MHC class II, Erysipelotrichaceae" @default.
• W3208784609 created "2021-11-08" @default.
• W3208784609 creator A5035995314 @default.
• W3208784609 creator A5062648086 @default.
• W3208784609 creator A5088967704 @default.
• W3208784609 date "2021-10-29" @default.
• W3208784609 modified "2023-09-23" @default.
• W3208784609 title "Low Abundance Members of the Gut Microbiome are Potent Drivers of Immune Cell Education." @default.
• W3208784609 cites W111506997 @default.
• W3208784609 cites W1523266228 @default.
• W3208784609 cites W1608285835 @default.
• W3208784609 cites W1900588411 @default.
• W3208784609 cites W1901435509 @default.
• W3208784609 cites W1968482421 @default.
• W3208784609 cites W1971109432 @default.
• W3208784609 cites W1977428376 @default.
• W3208784609 cites W1979217507 @default.
• W3208784609 cites W1981178699 @default.
• W3208784609 cites W1987266449 @default.
• W3208784609 cites W1987375206 @default.
• W3208784609 cites W1993870987 @default.
• W3208784609 cites W2006292369 @default.
• W3208784609 cites W2017940013 @default.
• W3208784609 cites W2018983025 @default.
• W3208784609 cites W2020913417 @default.
• W3208784609 cites W2022164897 @default.
• W3208784609 cites W2032230795 @default.
• W3208784609 cites W2043248182 @default.
• W3208784609 cites W2056279562 @default.
• W3208784609 cites W2059385530 @default.
• W3208784609 cites W2061948662 @default.
• W3208784609 cites W2070834379 @default.
• W3208784609 cites W2085284704 @default.
• W3208784609 cites W2090443712 @default.
• W3208784609 cites W2096139589 @default.
• W3208784609 cites W2097948046 @default.
• W3208784609 cites W2099540110 @default.
• W3208784609 cites W2103296919 @default.
• W3208784609 cites W2104401247 @default.
• W3208784609 cites W2119842624 @default.
• W3208784609 cites W2122242590 @default.
• W3208784609 cites W2131271579 @default.
• W3208784609 cites W2133856765 @default.
• W3208784609 cites W2135168953 @default.
• W3208784609 cites W2144084363 @default.
• W3208784609 cites W2159675211 @default.
• W3208784609 cites W2169330513 @default.
• W3208784609 cites W2169456326 @default.
• W3208784609 cites W2170024099 @default.
• W3208784609 cites W2171045789 @default.
• W3208784609 cites W2179438025 @default.
• W3208784609 cites W2342314812 @default.
• W3208784609 cites W2401404581 @default.
• W3208784609 cites W2592367925 @default.
• W3208784609 cites W2604634594 @default.
• W3208784609 cites W2751128104 @default.
• W3208784609 cites W2783921253 @default.
• W3208784609 cites W2794480084 @default.
• W3208784609 cites W2804854320 @default.
• W3208784609 cites W2806362852 @default.
• W3208784609 cites W2893910912 @default.
• W3208784609 cites W2897204056 @default.
• W3208784609 cites W2940790373 @default.
• W3208784609 cites W2944545583 @default.
• W3208784609 cites W2960486968 @default.
• W3208784609 cites W2963276645 @default.
• W3208784609 cites W2977433364 @default.
• W3208784609 cites W2978191106 @default.
• W3208784609 cites W3002200883 @default.
• W3208784609 cites W3027658010 @default.
• W3208784609 cites W3083241614 @default.
• W3208784609 cites W3098470064 @default.
• W3208784609 cites W3127870350 @default.
• W3208784609 doi "https://doi.org/10.21203/rs.3.rs-996487/v1" @default.
• W3208784609 hasPublicationYear "2021" @default.
• W3208784609 type Work @default.
• W3208784609 sameAs 3208784609 @default.
• W3208784609 citedByCount "0" @default.
• W3208784609 crossrefType "posted-content" @default.
• W3208784609 hasAuthorship W3208784609A5035995314 @default.
• W3208784609 hasAuthorship W3208784609A5062648086 @default.
• W3208784609 hasAuthorship W3208784609A5088967704 @default.
• W3208784609 hasBestOaLocation W32087846091 @default.
• W3208784609 hasConcept C104317684 @default.
• W3208784609 hasConcept C126831891 @default.
• W3208784609 hasConcept C127716648 @default.
• W3208784609 hasConcept C143121216 @default.
• W3208784609 hasConcept C18903297 @default.
• W3208784609 hasConcept C203014093 @default.
• W3208784609 hasConcept C523546767 @default.
• W3208784609 hasConcept C54355233 @default.
• W3208784609 hasConcept C77077793 @default.
• W3208784609 hasConcept C86803240 @default.
• W3208784609 hasConcept C8891405 @default.
• W3208784609 hasConcept C89423630 @default.
• W3208784609 hasConceptScore W3208784609C104317684 @default.
• W3208784609 hasConceptScore W3208784609C126831891 @default.
• W3208784609 hasConceptScore W3208784609C127716648 @default.
• W3208784609 hasConceptScore W3208784609C143121216 @default.
• W3208784609 hasConceptScore W3208784609C18903297 @default.

• next