Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208796585> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W3208796585 abstract "Objective: We describe two cases of Marchiafava-Bignami disease which have been treated with amantadine and discuss a potential mechanism. Background: Several reports have described the use of amantadine in the management of Marchiafava-Bignami disease (MBD); however, its role is unclear and there are no known mechanisms. Design/Methods: NA Results: Case 1: A 38 year-old woman with excessive wine drinking presented with agitation, impaired speech, and minimally conscious state. MRI revealed lesions in the splenium and genu. After a diagnosis of MBD she was treated with IV thiamin, multivitamins, and amantadine 100mg BID for two weeks. She recovered to near baseline after three weeks. Case 2: A 54 year-old woman with years of heavy alcohol use presented with sudden bradyphrenia, acalculia, disinhibited behavior, weakness and urinary incontinence. MRI revealed a large anterior callosal lesion. Two months after initial recovery from MBD she noted that consuming “energy drinks” resulted in a transient near-complete resolution of her residual behavioral, fatigue, and language symptoms. As amantadine could potentially mimic this effect, 100 mg BID was trialed with noted improvement. A further escalation to 200 mg TID was trialed, resulting in significant improvement in language and behavioral symptoms. Conclusions: A treatment approach for MBD is not established. In addition to our cases, two other reports have described the use of amantadine in MBD. The mechanism of amantadine’s role in MBD is unknown. It is possible that the dopaminergic effect of amantadine leads to an improved recovery and function in dopamine mediated pathways, including mesocortical and mesolimbic pathways, in the initial recovery as well as improved speech, behavior, and fatigue months after initial recovery. Support for this theory comes from studies in TBI where amantadine has shown increases in prefrontal cortical metabolic activity and a possible increase in striatal D2 dopamine– receptor availability. Disclosure: Dr. Kesayan has nothing to disclose. Dr. Myers has nothing to disclose." @default.
- W3208796585 created "2021-11-08" @default.
- W3208796585 creator A5053198637 @default.
- W3208796585 creator A5055186763 @default.
- W3208796585 date "2020-04-14" @default.
- W3208796585 modified "2023-09-24" @default.
- W3208796585 title "Amantadine as a potential treatment for Marchiafava-Bignami disease: case series and possible mechanism (754)" @default.
- W3208796585 hasPublicationYear "2020" @default.
- W3208796585 type Work @default.
- W3208796585 sameAs 3208796585 @default.
- W3208796585 citedByCount "0" @default.
- W3208796585 crossrefType "journal-article" @default.
- W3208796585 hasAuthorship W3208796585A5053198637 @default.
- W3208796585 hasAuthorship W3208796585A5055186763 @default.
- W3208796585 hasConcept C111472728 @default.
- W3208796585 hasConcept C126322002 @default.
- W3208796585 hasConcept C137183658 @default.
- W3208796585 hasConcept C138885662 @default.
- W3208796585 hasConcept C15744967 @default.
- W3208796585 hasConcept C169760540 @default.
- W3208796585 hasConcept C2777374534 @default.
- W3208796585 hasConcept C513476851 @default.
- W3208796585 hasConcept C71924100 @default.
- W3208796585 hasConcept C89611455 @default.
- W3208796585 hasConceptScore W3208796585C111472728 @default.
- W3208796585 hasConceptScore W3208796585C126322002 @default.
- W3208796585 hasConceptScore W3208796585C137183658 @default.
- W3208796585 hasConceptScore W3208796585C138885662 @default.
- W3208796585 hasConceptScore W3208796585C15744967 @default.
- W3208796585 hasConceptScore W3208796585C169760540 @default.
- W3208796585 hasConceptScore W3208796585C2777374534 @default.
- W3208796585 hasConceptScore W3208796585C513476851 @default.
- W3208796585 hasConceptScore W3208796585C71924100 @default.
- W3208796585 hasConceptScore W3208796585C89611455 @default.
- W3208796585 hasLocation W32087965851 @default.
- W3208796585 hasOpenAccess W3208796585 @default.
- W3208796585 hasPrimaryLocation W32087965851 @default.
- W3208796585 hasRelatedWork W1672489712 @default.
- W3208796585 hasRelatedWork W1969486559 @default.
- W3208796585 hasRelatedWork W1978703469 @default.
- W3208796585 hasRelatedWork W1981083945 @default.
- W3208796585 hasRelatedWork W2017747020 @default.
- W3208796585 hasRelatedWork W2018307066 @default.
- W3208796585 hasRelatedWork W2063025030 @default.
- W3208796585 hasRelatedWork W2063746048 @default.
- W3208796585 hasRelatedWork W2097025648 @default.
- W3208796585 hasRelatedWork W2215601016 @default.
- W3208796585 hasRelatedWork W2320139522 @default.
- W3208796585 hasRelatedWork W2337076360 @default.
- W3208796585 hasRelatedWork W2339778554 @default.
- W3208796585 hasRelatedWork W2373024652 @default.
- W3208796585 hasRelatedWork W2395323866 @default.
- W3208796585 hasRelatedWork W2401690177 @default.
- W3208796585 hasRelatedWork W2523815133 @default.
- W3208796585 hasRelatedWork W2883258859 @default.
- W3208796585 hasRelatedWork W2947857918 @default.
- W3208796585 hasRelatedWork W3025030949 @default.
- W3208796585 hasVolume "94" @default.
- W3208796585 isParatext "false" @default.
- W3208796585 isRetracted "false" @default.
- W3208796585 magId "3208796585" @default.
- W3208796585 workType "article" @default.