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- W3208797851 endingPage "1715" @default.
- W3208797851 startingPage "1715" @default.
- W3208797851 abstract "Neural tissue is one of the main oxygen consumers in the mammalian body, and a plentitude of metabolic as well as signaling processes within the brain is accompanied by the generation of reactive oxygen (ROS) and nitrogen (RNS) species. Besides the important signaling roles, both ROS and RNS can damage/modify the self-derived cellular components thus promoting neuroinflammation and oxidative stress. While previously, the latter processes were thought to progress linearly with age, newer data point to midlife as a critical turning point. Here, we describe (i) the main pathways leading to ROS/RNS generation within the brain, (ii) the main defense systems for their neutralization and (iii) summarize the recent literature about considerable changes in the energy/ROS homeostasis as well as activation state of the brain's immune system at midlife. Finally, we discuss the role of calorie restriction as a readily available and cost-efficient antiaging and antioxidant lifestyle intervention." @default.
- W3208797851 created "2021-11-08" @default.
- W3208797851 creator A5019498638 @default.
- W3208797851 creator A5025303972 @default.
- W3208797851 creator A5026342960 @default.
- W3208797851 creator A5075530137 @default.
- W3208797851 date "2021-10-28" @default.
- W3208797851 modified "2023-10-18" @default.
- W3208797851 title "Oxidative Stress and Energy Metabolism in the Brain: Midlife as a Turning Point" @default.
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