FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208798941> ?p ?o ?g. }

• W3208798941 abstract "SARS-CoV-2 is a positive-sense single-stranded RNA virus with emerging mutations, especially on the Spike glycoprotein (S protein). To delineate the genomic diversity in association with geographic dispersion of SARS-CoV-2 variant lineages, we collected 939,591 complete S protein sequences deposited in the Global Initiative on Sharing All Influenza Data (GISAID) from December 2019 to April 2021. An exponential emergence of S protein variants was observed since October 2020 when the four major variants of concern (VOCs), namely, alpha (α) (B.1.1.7), beta (β) (B.1.351), gamma (γ) (P.1), and delta (δ) (B.1.617), started to circulate in various communities. We found that residues 452, 477, 484, and 501, the 4 key amino acids located in the hACE2 binding domain of S protein, were under positive selection. Through in silico protein structure prediction and immunoinformatics tools, we discovered D614G is the key determinant to S protein conformational change, while variations of N439K, T478I, E484K, and N501Y in S1-RBD also had an impact on S protein binding affinity to hACE2 and antigenicity. Finally, we predicted that the yet-to-be-identified hypothetical N439S, T478S, and N501K mutations could confer an even greater binding affinity to hACE2 and evade host immune surveillance more efficiently than the respective native variants. This study documented the evolution of SARS-CoV-2 S protein over the first 16 months of the pandemic and identified several key amino acid changes that are predicted to confer a substantial impact on transmission and immunological recognition. These findings convey crucial information to sequence-based surveillance programs and the design of next-generation vaccines. IMPORTANCE Our study showed the global distribution of SARS-CoV-2 S protein variants from January 2020 to the end of April 2021. We highlighted the key amino acids of S protein subjected to positive selection. Using computer-aided approaches, we predicted the impact of the amino acid variations in S protein on viral infectivity and antigenicity. We also predicted the potential amino acid mutations that could arise in favor of SARS-CoV-2 virulence. These findings are vital for vaccine designing and anti-SARS-CoV-2 drug discovery in an effort to combat COVID-19." @default.
• W3208798941 created "2021-11-08" @default.
• W3208798941 creator A5004257102 @default.
• W3208798941 creator A5005452280 @default.
• W3208798941 creator A5018677121 @default.
• W3208798941 creator A5051255494 @default.
• W3208798941 creator A5053239739 @default.
• W3208798941 creator A5055323255 @default.
• W3208798941 creator A5058338096 @default.
• W3208798941 creator A5065617411 @default.
• W3208798941 creator A5074615044 @default.
• W3208798941 creator A5075559165 @default.
• W3208798941 date "2021-10-26" @default.
• W3208798941 modified "2023-09-26" @default.
• W3208798941 title "Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using <i>in Silico</i> Approach" @default.
• W3208798941 cites W1973980688 @default.
• W3208798941 cites W2028302194 @default.
• W3208798941 cites W2031160264 @default.
• W3208798941 cites W2104474203 @default.
• W3208798941 cites W2108512869 @default.
• W3208798941 cites W2132629607 @default.
• W3208798941 cites W2141747524 @default.
• W3208798941 cites W2152528032 @default.
• W3208798941 cites W2160397907 @default.
• W3208798941 cites W2160868144 @default.
• W3208798941 cites W2168696662 @default.
• W3208798941 cites W2170747616 @default.
• W3208798941 cites W2538584349 @default.
• W3208798941 cites W2611314002 @default.
• W3208798941 cites W2804822363 @default.
• W3208798941 cites W2886709672 @default.
• W3208798941 cites W3001118548 @default.
• W3208798941 cites W3004318991 @default.
• W3208798941 cites W3006116465 @default.
• W3208798941 cites W3007643904 @default.
• W3208798941 cites W3007831031 @default.
• W3208798941 cites W3009335299 @default.
• W3208798941 cites W3014067025 @default.
• W3208798941 cites W3023494626 @default.
• W3208798941 cites W3033524464 @default.
• W3208798941 cites W3039901154 @default.
• W3208798941 cites W3040801746 @default.
• W3208798941 cites W3043124965 @default.
• W3208798941 cites W3043431476 @default.
• W3208798941 cites W3046463683 @default.
• W3208798941 cites W3084653951 @default.
• W3208798941 cites W3087521091 @default.
• W3208798941 cites W3093768302 @default.
• W3208798941 cites W3096064145 @default.
• W3208798941 cites W3098697637 @default.
• W3208798941 cites W3101992496 @default.
• W3208798941 cites W3103843063 @default.
• W3208798941 cites W3107112434 @default.
• W3208798941 cites W3112267440 @default.
• W3208798941 cites W3119231619 @default.
• W3208798941 cites W3125590130 @default.
• W3208798941 cites W3127277789 @default.
• W3208798941 cites W3129422067 @default.
• W3208798941 cites W3136193945 @default.
• W3208798941 cites W3136828643 @default.
• W3208798941 cites W3137409463 @default.
• W3208798941 cites W3153528761 @default.
• W3208798941 cites W3154308199 @default.
• W3208798941 cites W3158062106 @default.
• W3208798941 cites W3160661183 @default.
• W3208798941 cites W3165656738 @default.
• W3208798941 cites W3177428124 @default.
• W3208798941 doi "https://doi.org/10.1128/mbio.02687-21" @default.
• W3208798941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8546546" @default.
• W3208798941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34700382" @default.
• W3208798941 hasPublicationYear "2021" @default.
• W3208798941 type Work @default.
• W3208798941 sameAs 3208798941 @default.
• W3208798941 citedByCount "2" @default.
• W3208798941 countsByYear W32087989412022 @default.
• W3208798941 crossrefType "journal-article" @default.
• W3208798941 hasAuthorship W3208798941A5004257102 @default.
• W3208798941 hasAuthorship W3208798941A5005452280 @default.
• W3208798941 hasAuthorship W3208798941A5018677121 @default.
• W3208798941 hasAuthorship W3208798941A5051255494 @default.
• W3208798941 hasAuthorship W3208798941A5053239739 @default.
• W3208798941 hasAuthorship W3208798941A5055323255 @default.
• W3208798941 hasAuthorship W3208798941A5058338096 @default.
• W3208798941 hasAuthorship W3208798941A5065617411 @default.
• W3208798941 hasAuthorship W3208798941A5074615044 @default.
• W3208798941 hasAuthorship W3208798941A5075559165 @default.
• W3208798941 hasBestOaLocation W32087989411 @default.
• W3208798941 hasConcept C104317684 @default.
• W3208798941 hasConcept C108625454 @default.
• W3208798941 hasConcept C142724271 @default.
• W3208798941 hasConcept C144292202 @default.
• W3208798941 hasConcept C159047783 @default.
• W3208798941 hasConcept C2775905019 @default.
• W3208798941 hasConcept C2779134260 @default.
• W3208798941 hasConcept C3007834351 @default.
• W3208798941 hasConcept C3008058167 @default.
• W3208798941 hasConcept C47701112 @default.
• W3208798941 hasConcept C524204448 @default.
• W3208798941 hasConcept C54355233 @default.
• W3208798941 hasConcept C55493867 @default.

• next