FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208806171> ?p ?o ?g. }

• W3208806171 abstract "Tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TIPE2) is a newly discovered negative immunoregulatory protein that is involved in various cellular immune responses to infections. However, the underlying mechanism by which TIPE2 affects the immune function of dendritic cells (DCs) is not yet understood. This study aimed to determine the correlations among DCs TIPE2 expression, autophagic activity and immune function in the context of sepsis. In addition, the signaling pathway by which TIPE2 regulates autophagy in DCs was investigated. We reported for the first time that TIPE2 overexpression (knock-in, KI) exerted an inhibitory effect on autophagy in DCs and markedly suppressed the immune function of DCs upon septic challenge both in vitro and in vivo. In addition, TIPE2 knockout (KO) in DCs significantly enhanced autophagy and improved the immune response of DCs in sepsis. Of note, we found that the transforming growth factor-β (TGF-β)-activated kinase-1 (TAK1)/c-Jun N-terminal kinase (JNK) pathway was inhibited by TIPE2 in DCs, resulting in downregulated autophagic activity. Collectively, these results suggest that TIPE2 can suppress the autophagic activity of DCs by inhibiting the TAK1/JNK signaling pathway and further negatively regulate the immune function of DCs in the development of septic complications." @default.
• W3208806171 created "2021-11-08" @default.
• W3208806171 creator A5007884136 @default.
• W3208806171 creator A5008479914 @default.
• W3208806171 creator A5026233587 @default.
• W3208806171 creator A5047497252 @default.
• W3208806171 creator A5050702153 @default.
• W3208806171 creator A5077429502 @default.
• W3208806171 date "2021-10-30" @default.
• W3208806171 modified "2023-10-16" @default.
• W3208806171 title "TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice" @default.
• W3208806171 cites W1944495665 @default.
• W3208806171 cites W1944758471 @default.
• W3208806171 cites W1966778344 @default.
• W3208806171 cites W1969437137 @default.
• W3208806171 cites W1989298032 @default.
• W3208806171 cites W2013071061 @default.
• W3208806171 cites W2025665129 @default.
• W3208806171 cites W2027612537 @default.
• W3208806171 cites W2050047423 @default.
• W3208806171 cites W2101082552 @default.
• W3208806171 cites W2110866843 @default.
• W3208806171 cites W2118588079 @default.
• W3208806171 cites W2121429373 @default.
• W3208806171 cites W2124420768 @default.
• W3208806171 cites W2157697972 @default.
• W3208806171 cites W2165158988 @default.
• W3208806171 cites W2169833800 @default.
• W3208806171 cites W2312563547 @default.
• W3208806171 cites W2507437658 @default.
• W3208806171 cites W2540365220 @default.
• W3208806171 cites W2586078640 @default.
• W3208806171 cites W2608823051 @default.
• W3208806171 cites W2617620062 @default.
• W3208806171 cites W2747125926 @default.
• W3208806171 cites W2755626276 @default.
• W3208806171 cites W2761040354 @default.
• W3208806171 cites W2774868879 @default.
• W3208806171 cites W2794396490 @default.
• W3208806171 cites W2808829764 @default.
• W3208806171 cites W2884946210 @default.
• W3208806171 cites W2889450693 @default.
• W3208806171 cites W2901252006 @default.
• W3208806171 cites W2914157352 @default.
• W3208806171 cites W2914890099 @default.
• W3208806171 cites W2922915037 @default.
• W3208806171 cites W2942217347 @default.
• W3208806171 cites W2944241989 @default.
• W3208806171 cites W2954367230 @default.
• W3208806171 cites W2956210295 @default.
• W3208806171 cites W2961899227 @default.
• W3208806171 cites W2979715803 @default.
• W3208806171 cites W2980818051 @default.
• W3208806171 cites W3006408605 @default.
• W3208806171 cites W3008812352 @default.
• W3208806171 cites W3106860548 @default.
• W3208806171 cites W638613648 @default.
• W3208806171 doi "https://doi.org/10.1038/s41419-021-04327-x" @default.
• W3208806171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8557212" @default.
• W3208806171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34718337" @default.
• W3208806171 hasPublicationYear "2021" @default.
• W3208806171 type Work @default.
• W3208806171 sameAs 3208806171 @default.
• W3208806171 citedByCount "11" @default.
• W3208806171 countsByYear W32088061712022 @default.
• W3208806171 countsByYear W32088061712023 @default.
• W3208806171 crossrefType "journal-article" @default.
• W3208806171 hasAuthorship W3208806171A5007884136 @default.
• W3208806171 hasAuthorship W3208806171A5008479914 @default.
• W3208806171 hasAuthorship W3208806171A5026233587 @default.
• W3208806171 hasAuthorship W3208806171A5047497252 @default.
• W3208806171 hasAuthorship W3208806171A5050702153 @default.
• W3208806171 hasAuthorship W3208806171A5077429502 @default.
• W3208806171 hasBestOaLocation W32088061711 @default.
• W3208806171 hasConcept C17991360 @default.
• W3208806171 hasConcept C184235292 @default.
• W3208806171 hasConcept C185592680 @default.
• W3208806171 hasConcept C190283241 @default.
• W3208806171 hasConcept C203014093 @default.
• W3208806171 hasConcept C203522944 @default.
• W3208806171 hasConcept C55493867 @default.
• W3208806171 hasConcept C62478195 @default.
• W3208806171 hasConcept C86803240 @default.
• W3208806171 hasConcept C8891405 @default.
• W3208806171 hasConcept C95444343 @default.
• W3208806171 hasConcept C97029542 @default.
• W3208806171 hasConceptScore W3208806171C17991360 @default.
• W3208806171 hasConceptScore W3208806171C184235292 @default.
• W3208806171 hasConceptScore W3208806171C185592680 @default.
• W3208806171 hasConceptScore W3208806171C190283241 @default.
• W3208806171 hasConceptScore W3208806171C203014093 @default.
• W3208806171 hasConceptScore W3208806171C203522944 @default.
• W3208806171 hasConceptScore W3208806171C55493867 @default.
• W3208806171 hasConceptScore W3208806171C62478195 @default.
• W3208806171 hasConceptScore W3208806171C86803240 @default.
• W3208806171 hasConceptScore W3208806171C8891405 @default.
• W3208806171 hasConceptScore W3208806171C95444343 @default.
• W3208806171 hasConceptScore W3208806171C97029542 @default.
• W3208806171 hasFunder F4320321001 @default.
• W3208806171 hasIssue "11" @default.

• next