Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208841102> ?p ?o ?g. }
- W3208841102 endingPage "1637" @default.
- W3208841102 startingPage "1621" @default.
- W3208841102 abstract "Electron paramagnetic resonance oximetry using the OxyChip as an implantable oxygen sensor can directly and repeatedly measure tissue oxygen levels. A phase I, first-in-human clinical study has established the safety and feasibility of using OxyChip for reliable and repeated measurements of oxygen levels in a variety of tumors and treatment regimens. A limitation in these studies is the inability to easily locate and identify the implanted probes in the tissue, particularly in the long term, thus limiting spatial/anatomical registration of the implant for proper interpretation of the oxygen data. In this study, we have developed and evaluated an enhanced oxygen-sensing probe embedded with gold nanoparticles (GNP), called the OxyChip-GNP, to enable visualization of the sensor using routine clinical imaging modalities.In vitro characterization, imaging, and histopathology studies were carried out using tissue phantoms, excised tissues, and in vivo animal models (mice and rats).The results demonstrated a substantial enhancement of ultrasound and CT contrast using the OxyChip-GNP without compromising its electron paramagnetic resonance and oxygen-sensing properties or biocompatibility.The OxyChips embedded with gold nanoparticles (OxyChip-GNP) can be readily identified in soft tissues using standard clinical imaging modalities such as CT, cone beam-CT, or ultrasound imaging while maintaining its capability to make repeated in vivo measurements of tissue oxygen levels over the long term. This unique capability of the OxyChip-GNP facilitates precisely localized in vivo oxygen measurements in the clinical setting." @default.
- W3208841102 created "2021-11-08" @default.
- W3208841102 creator A5000616950 @default.
- W3208841102 creator A5029240523 @default.
- W3208841102 creator A5037226537 @default.
- W3208841102 creator A5037635908 @default.
- W3208841102 creator A5063204661 @default.
- W3208841102 creator A5069043394 @default.
- W3208841102 creator A5082053391 @default.
- W3208841102 date "2021-10-31" @default.
- W3208841102 modified "2023-10-14" @default.
- W3208841102 title "OxyChip embedded with radio‐opaque gold nanoparticles for anatomic registration and oximetry in tissues" @default.
- W3208841102 cites W118442127 @default.
- W3208841102 cites W1630602429 @default.
- W3208841102 cites W1728528260 @default.
- W3208841102 cites W1951465258 @default.
- W3208841102 cites W1966854150 @default.
- W3208841102 cites W1981469372 @default.
- W3208841102 cites W1983631802 @default.
- W3208841102 cites W1986025529 @default.
- W3208841102 cites W1987579090 @default.
- W3208841102 cites W1989313199 @default.
- W3208841102 cites W2034280596 @default.
- W3208841102 cites W2048897226 @default.
- W3208841102 cites W2055672905 @default.
- W3208841102 cites W2063269161 @default.
- W3208841102 cites W2066325980 @default.
- W3208841102 cites W2072403698 @default.
- W3208841102 cites W2124340556 @default.
- W3208841102 cites W2129998516 @default.
- W3208841102 cites W2140880560 @default.
- W3208841102 cites W2146629016 @default.
- W3208841102 cites W2238193673 @default.
- W3208841102 cites W2514105187 @default.
- W3208841102 cites W2518219344 @default.
- W3208841102 cites W259041615 @default.
- W3208841102 cites W2607047313 @default.
- W3208841102 cites W2728068328 @default.
- W3208841102 cites W2791284009 @default.
- W3208841102 cites W2891322697 @default.
- W3208841102 cites W2901064099 @default.
- W3208841102 cites W2901643243 @default.
- W3208841102 cites W2914174874 @default.
- W3208841102 cites W2943586901 @default.
- W3208841102 cites W2948120122 @default.
- W3208841102 cites W2953837273 @default.
- W3208841102 cites W3021584780 @default.
- W3208841102 cites W3025872583 @default.
- W3208841102 cites W3095082915 @default.
- W3208841102 cites W3163508699 @default.
- W3208841102 cites W3202421483 @default.
- W3208841102 doi "https://doi.org/10.1002/mrm.29039" @default.
- W3208841102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719047" @default.
- W3208841102 hasPublicationYear "2021" @default.
- W3208841102 type Work @default.
- W3208841102 sameAs 3208841102 @default.
- W3208841102 citedByCount "0" @default.
- W3208841102 crossrefType "journal-article" @default.
- W3208841102 hasAuthorship W3208841102A5000616950 @default.
- W3208841102 hasAuthorship W3208841102A5029240523 @default.
- W3208841102 hasAuthorship W3208841102A5037226537 @default.
- W3208841102 hasAuthorship W3208841102A5037635908 @default.
- W3208841102 hasAuthorship W3208841102A5063204661 @default.
- W3208841102 hasAuthorship W3208841102A5069043394 @default.
- W3208841102 hasAuthorship W3208841102A5082053391 @default.
- W3208841102 hasBestOaLocation W32088411022 @default.
- W3208841102 hasConcept C126838900 @default.
- W3208841102 hasConcept C136229726 @default.
- W3208841102 hasConcept C143409427 @default.
- W3208841102 hasConcept C143753070 @default.
- W3208841102 hasConcept C150903083 @default.
- W3208841102 hasConcept C178790620 @default.
- W3208841102 hasConcept C185592680 @default.
- W3208841102 hasConcept C191897082 @default.
- W3208841102 hasConcept C192562407 @default.
- W3208841102 hasConcept C207001950 @default.
- W3208841102 hasConcept C2777230088 @default.
- W3208841102 hasConcept C40993552 @default.
- W3208841102 hasConcept C540031477 @default.
- W3208841102 hasConcept C71924100 @default.
- W3208841102 hasConcept C86803240 @default.
- W3208841102 hasConceptScore W3208841102C126838900 @default.
- W3208841102 hasConceptScore W3208841102C136229726 @default.
- W3208841102 hasConceptScore W3208841102C143409427 @default.
- W3208841102 hasConceptScore W3208841102C143753070 @default.
- W3208841102 hasConceptScore W3208841102C150903083 @default.
- W3208841102 hasConceptScore W3208841102C178790620 @default.
- W3208841102 hasConceptScore W3208841102C185592680 @default.
- W3208841102 hasConceptScore W3208841102C191897082 @default.
- W3208841102 hasConceptScore W3208841102C192562407 @default.
- W3208841102 hasConceptScore W3208841102C207001950 @default.
- W3208841102 hasConceptScore W3208841102C2777230088 @default.
- W3208841102 hasConceptScore W3208841102C40993552 @default.
- W3208841102 hasConceptScore W3208841102C540031477 @default.
- W3208841102 hasConceptScore W3208841102C71924100 @default.
- W3208841102 hasConceptScore W3208841102C86803240 @default.
- W3208841102 hasFunder F4320332161 @default.
- W3208841102 hasIssue "3" @default.