FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208858118> ?p ?o ?g. }

• W3208858118 endingPage "114026" @default.
• W3208858118 startingPage "114026" @default.
• W3208858118 abstract "Radiation therapy is a critical component of oncologic management, with more than half of all cancer patients requiring radiotherapy at some point during their disease course. Over the last decade, there has been increasing interest in charged particle therapy due to its advantageous physical and radiobiologic properties, with the therapeutic use of proton beam therapy (PBT) expanding worldwide. However, there remain large gaps in our knowledge of the radiobiologic mechanisms that underlie key aspects of PBT, such as variations in relative biologic effectiveness (RBE), radioresistance, DNA damage response and repair pathways, as well as immunologic effects. In addition, while the emerging technique of ultra-high dose rate or FLASH radiotherapy, with its potential to further reduce normal tissue toxicities, is an exciting development, in-depth study is needed into the postulated biochemical mechanisms that underpin the FLASH effect such as the oxygen depletion hypothesis as well as the relative contributions of immune responses and the tumor microenvironment. Further investigation is also required to ensure that the FLASH effect is not diminished or lost in PBT. Current methods to evaluate the biologic effects of charged particle therapy rely heavily on 2D cell culture systems and/or animal models. However, both of these methods have well-recognized limitations which limit translatability of findings from bench to bedside. The advent of novel three-dimensional in-vitro tumor models offers a more physiologically relevant and high throughput in-vitro system for the study of tumor development as well as novel therapeutic approaches such as PBT. Advances in 3D cell culture methods, together with knowledge of disease mechanism, biomarkers, and genomic data, can be used to design personalized 3D models that most closely recapitulate tumor microenvironmental factors promoting a particular disease phenotype, moving 3D models and PBT into the age of precision medicine." @default.
• W3208858118 created "2021-11-08" @default.
• W3208858118 creator A5034456156 @default.
• W3208858118 creator A5050580492 @default.
• W3208858118 creator A5074173045 @default.
• W3208858118 creator A5080841965 @default.
• W3208858118 date "2021-12-01" @default.
• W3208858118 modified "2023-09-30" @default.
• W3208858118 title "Technological and translational challenges for extracellular vesicle in therapy and diagnosis" @default.
• W3208858118 cites W3072606415 @default.
• W3208858118 cites W3154841599 @default.
• W3208858118 cites W3159421107 @default.
• W3208858118 cites W3160150547 @default.
• W3208858118 cites W3164138030 @default.
• W3208858118 cites W3164344780 @default.
• W3208858118 cites W3164386719 @default.
• W3208858118 cites W3166572063 @default.
• W3208858118 cites W3168134059 @default.
• W3208858118 cites W3170068038 @default.
• W3208858118 cites W3175183767 @default.
• W3208858118 cites W3176944510 @default.
• W3208858118 cites W3185963978 @default.
• W3208858118 cites W3195689182 @default.
• W3208858118 cites W3196369658 @default.
• W3208858118 cites W3201169293 @default.
• W3208858118 doi "https://doi.org/10.1016/j.addr.2021.114026" @default.
• W3208858118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34710528" @default.
• W3208858118 hasPublicationYear "2021" @default.
• W3208858118 type Work @default.
• W3208858118 sameAs 3208858118 @default.
• W3208858118 citedByCount "1" @default.
• W3208858118 countsByYear W32088581182023 @default.
• W3208858118 crossrefType "journal-article" @default.
• W3208858118 hasAuthorship W3208858118A5034456156 @default.
• W3208858118 hasAuthorship W3208858118A5050580492 @default.
• W3208858118 hasAuthorship W3208858118A5074173045 @default.
• W3208858118 hasAuthorship W3208858118A5080841965 @default.
• W3208858118 hasBestOaLocation W32088581182 @default.
• W3208858118 hasConcept C125118446 @default.
• W3208858118 hasConcept C126322002 @default.
• W3208858118 hasConcept C203014093 @default.
• W3208858118 hasConcept C2776107976 @default.
• W3208858118 hasConcept C2778418280 @default.
• W3208858118 hasConcept C2779244869 @default.
• W3208858118 hasConcept C502942594 @default.
• W3208858118 hasConcept C509974204 @default.
• W3208858118 hasConcept C58962609 @default.
• W3208858118 hasConcept C71924100 @default.
• W3208858118 hasConcept C8891405 @default.
• W3208858118 hasConceptScore W3208858118C125118446 @default.
• W3208858118 hasConceptScore W3208858118C126322002 @default.
• W3208858118 hasConceptScore W3208858118C203014093 @default.
• W3208858118 hasConceptScore W3208858118C2776107976 @default.
• W3208858118 hasConceptScore W3208858118C2778418280 @default.
• W3208858118 hasConceptScore W3208858118C2779244869 @default.
• W3208858118 hasConceptScore W3208858118C502942594 @default.
• W3208858118 hasConceptScore W3208858118C509974204 @default.
• W3208858118 hasConceptScore W3208858118C58962609 @default.
• W3208858118 hasConceptScore W3208858118C71924100 @default.
• W3208858118 hasConceptScore W3208858118C8891405 @default.
• W3208858118 hasLocation W32088581181 @default.
• W3208858118 hasLocation W32088581182 @default.
• W3208858118 hasLocation W32088581183 @default.
• W3208858118 hasLocation W32088581184 @default.
• W3208858118 hasOpenAccess W3208858118 @default.
• W3208858118 hasPrimaryLocation W32088581181 @default.
• W3208858118 hasRelatedWork W2066508575 @default.
• W3208858118 hasRelatedWork W2262669661 @default.
• W3208858118 hasRelatedWork W2305277255 @default.
• W3208858118 hasRelatedWork W2891309589 @default.
• W3208858118 hasRelatedWork W2972204910 @default.
• W3208858118 hasRelatedWork W3166432491 @default.
• W3208858118 hasRelatedWork W3208260243 @default.
• W3208858118 hasRelatedWork W4213322701 @default.
• W3208858118 hasRelatedWork W4220937030 @default.
• W3208858118 hasRelatedWork W598164398 @default.
• W3208858118 hasVolume "179" @default.
• W3208858118 isParatext "false" @default.
• W3208858118 isRetracted "false" @default.
• W3208858118 magId "3208858118" @default.
• W3208858118 workType "article" @default.