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• W3208860323 abstract "The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.The co-administration of nobiletin and anemarsaponin BII was investigated to explore the interaction and the potential mechanism.Male Sprague-Dawley rats were only orally administrated with 50 mg/kg nobiletin as the control and another six rats were pre-treated with 100 mg/kg anemarsaponin BII for 7 d followed by the administration of nobiletin. The transport and metabolic stability of nobiletin were evaluated in vitro, and the effect of anemarsaponin BII on the activity of CYP3A4 was also assessed to explore the potential mechanism underlying the interaction.The increasing Cmax (2309.67 ± 68.06 μg/L vs. 1767.67 ± 68.86 μg/L), AUC (28.84 ± 1.34 mg/L × h vs. 19.57 ± 2.76 mg/L × h), prolonged t1/2 (9.80 ± 2.33 h vs. 6.24 ± 1.53 h), and decreased clearance rate (1.46 ± 0.26 vs. 2.42 ± 0.40) of nobilein was observed in rats. Anemarsaponin BII significantly enhanced the metabolic stability of nobiletin in rat liver microsomes (half-life increased from 31.56 min to 39.44 min) and suppressed the transport of nobiletin in Caco-2 cells (efflux rate decreased from 1.57 ± 0.04 to 1.30 ± 0.03). The inhibitory effect of anemarsaponin BII on CYP3A4 was also found with an IC50 value of 10.23 μM.The interaction between anemarsaponin BII and nobiletin was induced by the inhibition of CYP3A4, which should draw special attention in their clinical co-administration." @default.
• W3208860323 created "2021-11-08" @default.
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• W3208860323 date "2021-01-01" @default.
• W3208860323 modified "2023-10-02" @default.
• W3208860323 title "The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII <i>in vivo</i> and <i>in vitro</i>" @default.
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• W3208860323 doi "https://doi.org/10.1080/13880209.2021.1990355" @default.
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