FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208876885> ?p ?o ?g. }

• W3208876885 endingPage "2812" @default.
• W3208876885 startingPage "2799" @default.
• W3208876885 abstract "Absent in melanoma-2 (AIM2) is an inflammasome-forming innate immune sensor for dsDNA but also exhibits inflammasome-independent functions such as restricting cellular proliferation. AIM2 is expressed in the kidney, but its localization and function are not fully characterized. In normal human glomeruli, AIM2 localized to podocytes. In patients with glomerulonephritis, AIM2 expression increased in CD44+-activated parietal epithelial cells within glomerular crescents. To explore AIM2 effects in glomerular disease, studies in Aim2-/- mice were performed. Aim2-/- glomeruli showed reduced expression of Wilm tumor gene-1 (WT1), WT1-driven podocyte genes, and increased proliferation in outgrowth assays. In a nephrotoxic serum (NTS)-induced glomerulonephritis model, Aim2-/- (B6) mice exhibited more severe glomerular crescent formation, tubular injury, inflammation, and proteinuria compared with wild-type controls. Inflammasome activation markers were absent in both Aim2-/- and wild-type kidneys, despite an increased inflammatory transcriptomic signature in Aim2-/- mice. Aim2-/- mice also demonstrated dysregulated cellular proliferation and an increase in CD44+ parietal epithelial cells during glomerulonephritis. The augmented inflammation and epithelial cell proliferation in Aim2-/- (B6) mice was not due to genetic background, as Aim2-/- (B6.129) mice demonstrated a similar phenotype during NTS glomerulonephritis. The AIM2-like receptor (ALR) locus was necessary for the inflammatory glomerulonephritis phenotype observed in Aim2-/- mice, as NTS-treated ALR-/- mice displayed equal levels of injury as wild-type controls. Podocyte outgrowth from ALR-/- glomeruli was still increased, however, confirming that the ALR locus is dispensable for AIM2 effects on epithelial cell proliferation. These results identify a noncanonical role for AIM2 in suppressing inflammation and epithelial cell proliferation during glomerulonephritis." @default.
• W3208876885 created "2021-11-08" @default.
• W3208876885 creator A5009145208 @default.
• W3208876885 creator A5009301036 @default.
• W3208876885 creator A5012324724 @default.
• W3208876885 creator A5016675533 @default.
• W3208876885 creator A5021583094 @default.
• W3208876885 creator A5024492944 @default.
• W3208876885 creator A5028295440 @default.
• W3208876885 creator A5038246464 @default.
• W3208876885 creator A5040562565 @default.
• W3208876885 creator A5046400641 @default.
• W3208876885 creator A5065828562 @default.
• W3208876885 creator A5074329775 @default.
• W3208876885 creator A5087094437 @default.
• W3208876885 date "2021-12-01" @default.
• W3208876885 modified "2023-10-18" @default.
• W3208876885 title "AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis" @default.
• W3208876885 cites W1805865584 @default.
• W3208876885 cites W1838170143 @default.
• W3208876885 cites W1918778447 @default.
• W3208876885 cites W1965035346 @default.
• W3208876885 cites W1968952749 @default.
• W3208876885 cites W1973518255 @default.
• W3208876885 cites W2017513144 @default.
• W3208876885 cites W2020054949 @default.
• W3208876885 cites W2028787589 @default.
• W3208876885 cites W2029184102 @default.
• W3208876885 cites W2031211461 @default.
• W3208876885 cites W2033198175 @default.
• W3208876885 cites W2042816890 @default.
• W3208876885 cites W2051011077 @default.
• W3208876885 cites W2053910475 @default.
• W3208876885 cites W2055890849 @default.
• W3208876885 cites W2070546514 @default.
• W3208876885 cites W2083245201 @default.
• W3208876885 cites W2093071529 @default.
• W3208876885 cites W2100892070 @default.
• W3208876885 cites W2101375867 @default.
• W3208876885 cites W2101975128 @default.
• W3208876885 cites W2103260279 @default.
• W3208876885 cites W2104195963 @default.
• W3208876885 cites W2108872143 @default.
• W3208876885 cites W2111144423 @default.
• W3208876885 cites W2113322063 @default.
• W3208876885 cites W2123240583 @default.
• W3208876885 cites W2128801503 @default.
• W3208876885 cites W2130905222 @default.
• W3208876885 cites W2133616161 @default.
• W3208876885 cites W2134510811 @default.
• W3208876885 cites W2140028599 @default.
• W3208876885 cites W2149336866 @default.
• W3208876885 cites W2156782644 @default.
• W3208876885 cites W2163406006 @default.
• W3208876885 cites W2166948652 @default.
• W3208876885 cites W2168287443 @default.
• W3208876885 cites W2276967039 @default.
• W3208876885 cites W2335465691 @default.
• W3208876885 cites W2336666739 @default.
• W3208876885 cites W2388616401 @default.
• W3208876885 cites W2398954616 @default.
• W3208876885 cites W2477702703 @default.
• W3208876885 cites W2497595434 @default.
• W3208876885 cites W2575953348 @default.
• W3208876885 cites W2596791985 @default.
• W3208876885 cites W2619266542 @default.
• W3208876885 cites W2724149674 @default.
• W3208876885 cites W2738501840 @default.
• W3208876885 cites W2753937826 @default.
• W3208876885 cites W2789143449 @default.
• W3208876885 cites W2955558978 @default.
• W3208876885 cites W3127042546 @default.
• W3208876885 cites W3198895821 @default.
• W3208876885 cites W4482768 @default.
• W3208876885 doi "https://doi.org/10.4049/jimmunol.2100483" @default.
• W3208876885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34740957" @default.
• W3208876885 hasPublicationYear "2021" @default.
• W3208876885 type Work @default.
• W3208876885 sameAs 3208876885 @default.
• W3208876885 citedByCount "10" @default.
• W3208876885 countsByYear W32088768852022 @default.
• W3208876885 countsByYear W32088768852023 @default.
• W3208876885 crossrefType "journal-article" @default.
• W3208876885 hasAuthorship W3208876885A5009145208 @default.
• W3208876885 hasAuthorship W3208876885A5009301036 @default.
• W3208876885 hasAuthorship W3208876885A5012324724 @default.
• W3208876885 hasAuthorship W3208876885A5016675533 @default.
• W3208876885 hasAuthorship W3208876885A5021583094 @default.
• W3208876885 hasAuthorship W3208876885A5024492944 @default.
• W3208876885 hasAuthorship W3208876885A5028295440 @default.
• W3208876885 hasAuthorship W3208876885A5038246464 @default.
• W3208876885 hasAuthorship W3208876885A5040562565 @default.
• W3208876885 hasAuthorship W3208876885A5046400641 @default.
• W3208876885 hasAuthorship W3208876885A5065828562 @default.
• W3208876885 hasAuthorship W3208876885A5074329775 @default.
• W3208876885 hasAuthorship W3208876885A5087094437 @default.
• W3208876885 hasBestOaLocation W32088768851 @default.
• W3208876885 hasConcept C134018914 @default.

• next