Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208889782> ?p ?o ?g. }
- W3208889782 endingPage "11946" @default.
- W3208889782 startingPage "11946" @default.
- W3208889782 abstract "Glutaredoxins (GRXs), important components of the intracellular thiol redox system, are involved in multiple cellular processes. In a previous study, we identified five GRXs in the apicomplexan parasite, Neospora caninum. In the present study, we confirmed that the GRXs S14 and C5 are located in the apicoplast, which suggests unique functions for these proteins. Although single-gene deficiency did not affect the growth of parasites, a double knockout (Δgrx S14Δgrx C5) significantly reduced their reproductive capacity. However, there were no significant changes in redox indices (GSH/GSSG ratio, reactive oxygen species and hydroxyl radical levels) in double-knockout parasites, indicating that grx S14 and grx C5 are not essential for maintaining the redox balance in parasite cells. Key amino acid mutations confirmed that the Cys203 of grx S14 and Cys253/256 of grx C5 are important for parasite growth. Based on comparative proteomics, 79 proteins were significantly downregulated in double-knockout parasites, including proteins mainly involved in the electron transport chain, the tricarboxylic acid cycle and protein translation. Collectively, GRX S14 and GRX C5 coordinate the growth of parasites. However, considering their special localization, the unique functions of GRX S14 and GRX C5 need to be further studied." @default.
- W3208889782 created "2021-11-08" @default.
- W3208889782 creator A5028559320 @default.
- W3208889782 creator A5034227844 @default.
- W3208889782 creator A5034602654 @default.
- W3208889782 creator A5035282947 @default.
- W3208889782 creator A5039574991 @default.
- W3208889782 creator A5054223932 @default.
- W3208889782 date "2021-11-04" @default.
- W3208889782 modified "2023-10-05" @default.
- W3208889782 title "Identification and Function of Apicoplast Glutaredoxins in Neospora caninum" @default.
- W3208889782 cites W1960903263 @default.
- W3208889782 cites W1971421866 @default.
- W3208889782 cites W1989285795 @default.
- W3208889782 cites W1993669834 @default.
- W3208889782 cites W1994915198 @default.
- W3208889782 cites W2011894392 @default.
- W3208889782 cites W2017713186 @default.
- W3208889782 cites W2021320037 @default.
- W3208889782 cites W2031934718 @default.
- W3208889782 cites W2034130529 @default.
- W3208889782 cites W2035539991 @default.
- W3208889782 cites W2035663414 @default.
- W3208889782 cites W2055657106 @default.
- W3208889782 cites W2057049100 @default.
- W3208889782 cites W2065789888 @default.
- W3208889782 cites W2069446599 @default.
- W3208889782 cites W2072285289 @default.
- W3208889782 cites W2080184255 @default.
- W3208889782 cites W2106541292 @default.
- W3208889782 cites W2110691019 @default.
- W3208889782 cites W2156896511 @default.
- W3208889782 cites W2249161905 @default.
- W3208889782 cites W2258781438 @default.
- W3208889782 cites W2538215728 @default.
- W3208889782 cites W2567975758 @default.
- W3208889782 cites W2604572729 @default.
- W3208889782 cites W2738155070 @default.
- W3208889782 cites W2787918313 @default.
- W3208889782 cites W2789732248 @default.
- W3208889782 cites W2791972889 @default.
- W3208889782 cites W3082218600 @default.
- W3208889782 cites W4211238896 @default.
- W3208889782 doi "https://doi.org/10.3390/ijms222111946" @default.
- W3208889782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8584781" @default.
- W3208889782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34769376" @default.
- W3208889782 hasPublicationYear "2021" @default.
- W3208889782 type Work @default.
- W3208889782 sameAs 3208889782 @default.
- W3208889782 citedByCount "3" @default.
- W3208889782 countsByYear W32088897822022 @default.
- W3208889782 countsByYear W32088897822023 @default.
- W3208889782 crossrefType "journal-article" @default.
- W3208889782 hasAuthorship W3208889782A5028559320 @default.
- W3208889782 hasAuthorship W3208889782A5034227844 @default.
- W3208889782 hasAuthorship W3208889782A5034602654 @default.
- W3208889782 hasAuthorship W3208889782A5035282947 @default.
- W3208889782 hasAuthorship W3208889782A5039574991 @default.
- W3208889782 hasAuthorship W3208889782A5054223932 @default.
- W3208889782 hasBestOaLocation W32088897821 @default.
- W3208889782 hasConcept C104317684 @default.
- W3208889782 hasConcept C125619963 @default.
- W3208889782 hasConcept C159654299 @default.
- W3208889782 hasConcept C2778128430 @default.
- W3208889782 hasConcept C2781154746 @default.
- W3208889782 hasConcept C3623737 @default.
- W3208889782 hasConcept C54355233 @default.
- W3208889782 hasConcept C55493867 @default.
- W3208889782 hasConcept C86803240 @default.
- W3208889782 hasConcept C95444343 @default.
- W3208889782 hasConceptScore W3208889782C104317684 @default.
- W3208889782 hasConceptScore W3208889782C125619963 @default.
- W3208889782 hasConceptScore W3208889782C159654299 @default.
- W3208889782 hasConceptScore W3208889782C2778128430 @default.
- W3208889782 hasConceptScore W3208889782C2781154746 @default.
- W3208889782 hasConceptScore W3208889782C3623737 @default.
- W3208889782 hasConceptScore W3208889782C54355233 @default.
- W3208889782 hasConceptScore W3208889782C55493867 @default.
- W3208889782 hasConceptScore W3208889782C86803240 @default.
- W3208889782 hasConceptScore W3208889782C95444343 @default.
- W3208889782 hasFunder F4320322919 @default.
- W3208889782 hasIssue "21" @default.
- W3208889782 hasLocation W32088897821 @default.
- W3208889782 hasLocation W32088897822 @default.
- W3208889782 hasLocation W32088897823 @default.
- W3208889782 hasLocation W32088897824 @default.
- W3208889782 hasOpenAccess W3208889782 @default.
- W3208889782 hasPrimaryLocation W32088897821 @default.
- W3208889782 hasRelatedWork W1651208294 @default.
- W3208889782 hasRelatedWork W1927440346 @default.
- W3208889782 hasRelatedWork W1997242330 @default.
- W3208889782 hasRelatedWork W1998428487 @default.
- W3208889782 hasRelatedWork W2026368793 @default.
- W3208889782 hasRelatedWork W2028097028 @default.
- W3208889782 hasRelatedWork W2094816404 @default.
- W3208889782 hasRelatedWork W2142070805 @default.
- W3208889782 hasRelatedWork W2145457451 @default.
- W3208889782 hasRelatedWork W3171663430 @default.