Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208896324> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3208896324 endingPage "S39" @default.
- W3208896324 startingPage "S39" @default.
- W3208896324 abstract "Abstract Introduction/Objective SMARCA4-deficient thoracic sarcoma/carcinoma is a highly aggressive neoplasm characterized by SMARCA4 (chromatin remodeling complex) deficiency. It affects mostly smokers (85%) with a broad age range of presentation (mean age: 50 years). Most patients present with advanced disease and extensive involvement of thoracic structures. The cytomorphologic features of this entity have not been fully described. Methods/Case Report A 59-year-old female, former smoker, with a prior history of lung adenocarcinoma, presented with a new 2.8 cm right infrahilar nodule concerning for recurrence. The second patient, a 54-year-old male who is a smoker, presented with an 8.0 cm right perihilar mass extending into the right lung and mediastinum with encasement of the right main pulmonary artery. Cytologically, the smears from both aspirates were comprised of single cells and loosely cohesive clusters of ovoid to spindle cells with scant to moderate cytoplasm, stippled chromatin, and focally prominent nucleoli. Numerous mitotic figures were appreciated. Necrosis was present within the smear background. The cell block sections showed tumor cells arranged in glandular and focal papillary architecture with a myxoid background. In one case, intermediate to large-sized cells with focal cytoplasmic clearing and patchy extracellular metachromatic material were also noted. Rhabdoid morphology was not appreciated. Immunohistochemically, the tumor cells were at least focally positive for vimentin, TLE-1, SALL4, CK AE1/AE3 and TTF-1, while being negative for CK7, CK20, Napsin-A, SOX-10, p40 and neuroendocrine markers. Both tumors showed SMARCA4 (BRG1) loss of expression. Results (if a Case Study enter NA) N/A Conclusion While the cytomorphologic findings of SMARCA4-deficient thoracic sarcomas/carcinomas are not specific, the FNA diagnosis should be considered for any poorly differentiated neoplasm involving the lungs or mediastinum which should prompt an appropriate immunocytochemical work-up that includes SMARCA4/BRG1 assessment" @default.
- W3208896324 created "2021-11-08" @default.
- W3208896324 creator A5026562709 @default.
- W3208896324 creator A5035435869 @default.
- W3208896324 creator A5074324018 @default.
- W3208896324 date "2021-10-01" @default.
- W3208896324 modified "2023-09-26" @default.
- W3208896324 title "Cytomorphologic findings of SMARCA4-deficient thoracic sarcoma/carcinoma: Report of two cases" @default.
- W3208896324 doi "https://doi.org/10.1093/ajcp/aqab191.077" @default.
- W3208896324 hasPublicationYear "2021" @default.
- W3208896324 type Work @default.
- W3208896324 sameAs 3208896324 @default.
- W3208896324 citedByCount "0" @default.
- W3208896324 crossrefType "journal-article" @default.
- W3208896324 hasAuthorship W3208896324A5026562709 @default.
- W3208896324 hasAuthorship W3208896324A5035435869 @default.
- W3208896324 hasAuthorship W3208896324A5074324018 @default.
- W3208896324 hasBestOaLocation W32088963241 @default.
- W3208896324 hasConcept C105702510 @default.
- W3208896324 hasConcept C126322002 @default.
- W3208896324 hasConcept C142724271 @default.
- W3208896324 hasConcept C167227067 @default.
- W3208896324 hasConcept C2777714996 @default.
- W3208896324 hasConcept C2779126056 @default.
- W3208896324 hasConcept C54355233 @default.
- W3208896324 hasConcept C552990157 @default.
- W3208896324 hasConcept C71924100 @default.
- W3208896324 hasConcept C80828422 @default.
- W3208896324 hasConcept C83640560 @default.
- W3208896324 hasConcept C86803240 @default.
- W3208896324 hasConceptScore W3208896324C105702510 @default.
- W3208896324 hasConceptScore W3208896324C126322002 @default.
- W3208896324 hasConceptScore W3208896324C142724271 @default.
- W3208896324 hasConceptScore W3208896324C167227067 @default.
- W3208896324 hasConceptScore W3208896324C2777714996 @default.
- W3208896324 hasConceptScore W3208896324C2779126056 @default.
- W3208896324 hasConceptScore W3208896324C54355233 @default.
- W3208896324 hasConceptScore W3208896324C552990157 @default.
- W3208896324 hasConceptScore W3208896324C71924100 @default.
- W3208896324 hasConceptScore W3208896324C80828422 @default.
- W3208896324 hasConceptScore W3208896324C83640560 @default.
- W3208896324 hasConceptScore W3208896324C86803240 @default.
- W3208896324 hasIssue "Supplement_1" @default.
- W3208896324 hasLocation W32088963241 @default.
- W3208896324 hasOpenAccess W3208896324 @default.
- W3208896324 hasPrimaryLocation W32088963241 @default.
- W3208896324 hasRelatedWork W14748471 @default.
- W3208896324 hasRelatedWork W20032244 @default.
- W3208896324 hasRelatedWork W21273632 @default.
- W3208896324 hasRelatedWork W21886592 @default.
- W3208896324 hasRelatedWork W2803901 @default.
- W3208896324 hasRelatedWork W3731881 @default.
- W3208896324 hasRelatedWork W385304 @default.
- W3208896324 hasRelatedWork W5451328 @default.
- W3208896324 hasRelatedWork W7847882 @default.
- W3208896324 hasRelatedWork W8063658 @default.
- W3208896324 hasVolume "156" @default.
- W3208896324 isParatext "false" @default.
- W3208896324 isRetracted "false" @default.
- W3208896324 magId "3208896324" @default.
- W3208896324 workType "article" @default.