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- W3208900810 abstract "Serotonin 2A receptor (5-HT2AR) agonist classic psychedelics are drawing increasing interest as potential mental health treatments. Recent work suggests psychedelics can exert persisting anxiolytic and antidepressant effects lasting up to several months after a single administration. Data indicate acute subjective drug effects as important psychological factors involved in observed therapeutic benefits. Additionally, animal models have shown an important role for 5-HT2AR agonists in modulating learning and memory function with relevance for Alzheimer's Disease (AD) and related dementias. A number of biological mechanisms of action are under investigation to elucidate 5-HT2AR agonists' therapeutic potential, including enhanced neuroplasticity, anti-inflammatory effects, and alterations in brain functional connectivity. These diverse lines of research are reviewed here along with a discussion of AD pathophysiology and neuropsychiatric symptoms to highlight classic psychedelics as potential novel pharmacotherapies for patients with AD. Human clinical research suggests a possible role for high-dose psychedelic administration in symptomatic treatment of depressed mood and anxiety in early-stage AD. Preclinical data indicate a potential for low- or high-dose psychedelic treatment regimens to slow or reverse brain atrophy, enhance cognitive function, and slow progression of AD. In conclusion, rationale and potential approaches for preliminary research with psychedelics in patients with AD are presented, and ramifications of this line of investigation for development of novel AD treatments are discussed." @default.
- W3208900810 created "2021-11-08" @default.
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- W3208900810 date "2021-01-01" @default.
- W3208900810 modified "2023-10-05" @default.
- W3208900810 title "Psychedelics as Novel Therapeutics in Alzheimer’s Disease: Rationale and Potential Mechanisms" @default.
- W3208900810 cites W1219728146 @default.
- W3208900810 cites W1531290450 @default.
- W3208900810 cites W1552179169 @default.
- W3208900810 cites W1585083630 @default.
- W3208900810 cites W1635746382 @default.
- W3208900810 cites W1664657655 @default.
- W3208900810 cites W173089895 @default.
- W3208900810 cites W1785160854 @default.
- W3208900810 cites W1856465854 @default.
- W3208900810 cites W1882482010 @default.
- W3208900810 cites W1900494133 @default.
- W3208900810 cites W1921053595 @default.
- W3208900810 cites W1965407423 @default.
- W3208900810 cites W1969793439 @default.
- W3208900810 cites W1969845534 @default.
- W3208900810 cites W1971459727 @default.
- W3208900810 cites W1978408307 @default.
- W3208900810 cites W1980574540 @default.
- W3208900810 cites W1983522355 @default.
- W3208900810 cites W1986073891 @default.
- W3208900810 cites W1986856619 @default.
- W3208900810 cites W1987496517 @default.
- W3208900810 cites W1990965698 @default.
- W3208900810 cites W1991128922 @default.
- W3208900810 cites W1994926162 @default.
- W3208900810 cites W1998477180 @default.
- W3208900810 cites W2001618696 @default.
- W3208900810 cites W2003665687 @default.
- W3208900810 cites W2008767130 @default.
- W3208900810 cites W2009134620 @default.
- W3208900810 cites W2011134915 @default.
- W3208900810 cites W2012693347 @default.
- W3208900810 cites W2013349550 @default.
- W3208900810 cites W2016575029 @default.
- W3208900810 cites W2017033087 @default.
- W3208900810 cites W2017666196 @default.
- W3208900810 cites W2021653459 @default.
- W3208900810 cites W2021809156 @default.
- W3208900810 cites W2025262281 @default.
- W3208900810 cites W2028834304 @default.
- W3208900810 cites W2030472555 @default.
- W3208900810 cites W2034491173 @default.
- W3208900810 cites W2041177833 @default.
- W3208900810 cites W2042102728 @default.
- W3208900810 cites W2042593075 @default.
- W3208900810 cites W2045076787 @default.
- W3208900810 cites W2048681279 @default.
- W3208900810 cites W2051271111 @default.
- W3208900810 cites W2052742260 @default.
- W3208900810 cites W2054754029 @default.
- W3208900810 cites W2055361873 @default.
- W3208900810 cites W2056045580 @default.
- W3208900810 cites W2056716542 @default.
- W3208900810 cites W2058248579 @default.
- W3208900810 cites W2059684345 @default.
- W3208900810 cites W2062539816 @default.
- W3208900810 cites W2066106579 @default.
- W3208900810 cites W2075238613 @default.
- W3208900810 cites W2078821747 @default.
- W3208900810 cites W2079749054 @default.
- W3208900810 cites W2082429191 @default.
- W3208900810 cites W2085670677 @default.
- W3208900810 cites W2086236919 @default.
- W3208900810 cites W2088361570 @default.
- W3208900810 cites W2089542831 @default.
- W3208900810 cites W2090188780 @default.
- W3208900810 cites W2093874807 @default.
- W3208900810 cites W2096963202 @default.
- W3208900810 cites W2097325576 @default.
- W3208900810 cites W2103186609 @default.
- W3208900810 cites W2104132043 @default.
- W3208900810 cites W2108335346 @default.
- W3208900810 cites W2111200377 @default.
- W3208900810 cites W2113099805 @default.
- W3208900810 cites W2116451919 @default.
- W3208900810 cites W2116709840 @default.
- W3208900810 cites W2118739111 @default.
- W3208900810 cites W2119134849 @default.
- W3208900810 cites W2119738402 @default.
- W3208900810 cites W2121756012 @default.
- W3208900810 cites W2122087907 @default.
- W3208900810 cites W2122459973 @default.
- W3208900810 cites W2122522567 @default.
- W3208900810 cites W2128667819 @default.
- W3208900810 cites W2129497119 @default.
- W3208900810 cites W2139214514 @default.
- W3208900810 cites W2140013897 @default.
- W3208900810 cites W2140172277 @default.