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- W3208909766 abstract "<h3>Objectives</h3> We aimed to evaluate the cut-off value of Ki67 that predicted survival in luminal breast cancer and investigated its survival impact according to axillary lymph node involvement. <h3>Methods</h3> We retrospectively selected 321 cases of histologically confirmed, early stage, breast cancer treated between 2011–2015. All patients had ER and/or PR positive (>10% expression) and HER2- tumors. We evaluated the prognostic value of several cut-off levels of Ki67 in terms overall survival (5-year OS): 14%, 20%, 30% and 50%. We also considered different subgroups according to axillary lymph node involvement: pN0(38%), 1–3pN+(35%) and ≥4pN+(27%). We used Kaplan Meier method and Cox regression models to evaluate survival. <h3>Results</h3> Median age was 49 years-old, 42% were menopausal. Media Ki67 was 28%. Sixty four percent of patients had mastectomy, 93% received chemotherapy and 88% radiation therapy. On overall population, after median follow-up of 51 months, we observed a significant difference in OS only with the Ki67 cut-off of 30% (67 vs 64 months, p=0.04, HR=0.79 IC à 95% [0.6–0.87]). In node negative pN0 population, Ki67 cut-off=20% was significantly associated with OS (72 vs 65 months, p=0.03, HR=0.83[0.63–0.92]). In node positive tumours different Ki 67 cut-off values did not predict survival except in ≥4pN+ group, where patients with Ki67>50% had significantly worse OS compared to patients≤50% (63 vs 30 months, p=0.01, HR=0.31 IC à 95% [0.22–0.65]). <h3>Conclusions</h3> Ki67 level in RH+/HER2- breast cancer predicted survival with the cut-off value of 30%. Ki67 had an impact on survival with a cut-off=20% in node negative and 50% in ≥4pN+ tumours." @default.
- W3208909766 created "2021-11-08" @default.
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- W3208909766 date "2021-11-01" @default.
- W3208909766 modified "2023-09-26" @default.
- W3208909766 title "EPV008/#139 Role of KI67 in predicting survival in RH+/HER2- breast cancer according to axillary nodal involvement" @default.
- W3208909766 doi "https://doi.org/10.1136/ijgc-2021-igcs.75" @default.
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