Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208919161> ?p ?o ?g. }
- W3208919161 endingPage "1820" @default.
- W3208919161 startingPage "1809" @default.
- W3208919161 abstract "Lithium has been a drug for bipolar disorders (BD) for over 70 years; however, its usage has been limited by its narrow therapeutic window (between 0.6 and 1.2 mM). Understanding the cellular distribution of lithium ions (Li+) in patient cells will offer deep insight into this limitation, but selective imaging of Li+ in living cells under biomedically relevant concentration ranges has not been achieved. Herein, we report in vitro selection and development of a Li+-specific DNAzyme fluorescent sensor with >100-fold selectivity over other biorelevant metal ions. This sensor allows comparative Li+ visualization in HeLa cells, human neuronal progenitor cells (NPCs), and neurons derived from BD patients and healthy controls. Strikingly, we detected enhanced accumulation of Li+ in cells derived from BD patients compared with healthy controls in differentiated neurons but not NPCs. These results establish the DNAzyme-based sensor as a novel platform for biomedical research into BD and related areas using lithium drugs." @default.
- W3208919161 created "2021-11-08" @default.
- W3208919161 creator A5008990506 @default.
- W3208919161 creator A5011415820 @default.
- W3208919161 creator A5012181735 @default.
- W3208919161 creator A5013242137 @default.
- W3208919161 creator A5019744464 @default.
- W3208919161 creator A5025862687 @default.
- W3208919161 creator A5030686904 @default.
- W3208919161 creator A5035740573 @default.
- W3208919161 creator A5044941670 @default.
- W3208919161 creator A5063251267 @default.
- W3208919161 creator A5064031570 @default.
- W3208919161 date "2021-11-03" @default.
- W3208919161 modified "2023-10-14" @default.
- W3208919161 title "DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons" @default.
- W3208919161 cites W176378175 @default.
- W3208919161 cites W1977680898 @default.
- W3208919161 cites W1977709085 @default.
- W3208919161 cites W1978013916 @default.
- W3208919161 cites W1979073863 @default.
- W3208919161 cites W1985747650 @default.
- W3208919161 cites W1987565198 @default.
- W3208919161 cites W1987911559 @default.
- W3208919161 cites W1995713813 @default.
- W3208919161 cites W1997285597 @default.
- W3208919161 cites W2002854512 @default.
- W3208919161 cites W2003835684 @default.
- W3208919161 cites W2009430519 @default.
- W3208919161 cites W2010935723 @default.
- W3208919161 cites W2012949323 @default.
- W3208919161 cites W2013976474 @default.
- W3208919161 cites W2020118719 @default.
- W3208919161 cites W2023166139 @default.
- W3208919161 cites W2025777672 @default.
- W3208919161 cites W2030767845 @default.
- W3208919161 cites W2032892360 @default.
- W3208919161 cites W2036821913 @default.
- W3208919161 cites W2038790563 @default.
- W3208919161 cites W2057436796 @default.
- W3208919161 cites W2059467538 @default.
- W3208919161 cites W2069688986 @default.
- W3208919161 cites W2071597330 @default.
- W3208919161 cites W2087775336 @default.
- W3208919161 cites W2092411608 @default.
- W3208919161 cites W2099017168 @default.
- W3208919161 cites W2101768182 @default.
- W3208919161 cites W2105915844 @default.
- W3208919161 cites W2113803200 @default.
- W3208919161 cites W2120434145 @default.
- W3208919161 cites W2121406336 @default.
- W3208919161 cites W2125987139 @default.
- W3208919161 cites W2134582520 @default.
- W3208919161 cites W2139372806 @default.
- W3208919161 cites W2141263950 @default.
- W3208919161 cites W2146015352 @default.
- W3208919161 cites W2185709237 @default.
- W3208919161 cites W2188981783 @default.
- W3208919161 cites W2255937135 @default.
- W3208919161 cites W2306814733 @default.
- W3208919161 cites W2313777562 @default.
- W3208919161 cites W2610823330 @default.
- W3208919161 cites W2623831325 @default.
- W3208919161 cites W2735495466 @default.
- W3208919161 cites W2766489363 @default.
- W3208919161 cites W2785981445 @default.
- W3208919161 cites W2791727878 @default.
- W3208919161 cites W2795783161 @default.
- W3208919161 cites W2806009144 @default.
- W3208919161 cites W2900711064 @default.
- W3208919161 cites W2922454853 @default.
- W3208919161 cites W2951660875 @default.
- W3208919161 cites W2952319084 @default.
- W3208919161 cites W2974762820 @default.
- W3208919161 cites W2986748392 @default.
- W3208919161 cites W2990273632 @default.
- W3208919161 cites W2992478910 @default.
- W3208919161 cites W3023733809 @default.
- W3208919161 cites W3027845215 @default.
- W3208919161 cites W3040935747 @default.
- W3208919161 cites W3083267042 @default.
- W3208919161 cites W3137328652 @default.
- W3208919161 cites W3175463943 @default.
- W3208919161 cites W3180851800 @default.
- W3208919161 cites W970644089 @default.
- W3208919161 doi "https://doi.org/10.1021/acscentsci.1c00843" @default.
- W3208919161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8614110" @default.
- W3208919161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34841055" @default.
- W3208919161 hasPublicationYear "2021" @default.
- W3208919161 type Work @default.
- W3208919161 sameAs 3208919161 @default.
- W3208919161 citedByCount "23" @default.
- W3208919161 countsByYear W32089191612021 @default.
- W3208919161 countsByYear W32089191612022 @default.
- W3208919161 countsByYear W32089191612023 @default.
- W3208919161 crossrefType "journal-article" @default.
- W3208919161 hasAuthorship W3208919161A5008990506 @default.
- W3208919161 hasAuthorship W3208919161A5011415820 @default.