FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208921000> ?p ?o ?g. }

• W3208921000 endingPage "883" @default.
• W3208921000 startingPage "870" @default.
• W3208921000 abstract "Citrobacter rodentium is a murine pathogenic bacterium that adheres to intestinal epithelial cells, resulting in loss of microvilli and pedestal formation, and alters multiple cellular processes, including actin dynamics. Translocated intimin receptor (Tir), one of its virulence factors, functions as receptor for intimin, a bacterial adhesin, thereby mediating bacterial adhesion to epithelial cells. Although robust immune responses are induced to eliminate pathogenic bacteria in the host, they are suppressed against harmless commensal bacteria. The mechanism(s) underlying such a differentiation remains unclear. This study sought to determine the roles of intimate adhesion in the induction of specific immune responses upon C. rodentium infection. To this end, microbiota-depleted mice were infected with the Tir-F strain expressing full-length Tir or mutant strains expressing the C-terminal truncated Tir that is defective in intimin binding and host cell actin polymerization. There were no differences in the colonization kinetics and Abs responses against C. rodentium LPS among the strains, whereas Abs against the virulence factors were only produced on Tir-F infection. Although there were no differences in the virulence factors mRNA expression levels, colonic hyperplasia, and bacterial translocation to the systemic organs irrespective of the strain, adhesion to colonic epithelial cells was reduced in the mutant strain-infected mice. Furthermore, transcriptomic analysis indicated that robust inflammatory and immune responses were only induced in the Tir-F-infected group and were suppressed in the mutant-infected groups. Taken together, these findings suggest that Tir-mediated intimate adhesion induces inflammatory and immune responses, resulting in the induction of virulence factor-specific Abs." @default.
• W3208921000 created "2021-11-08" @default.
• W3208921000 creator A5013900477 @default.
• W3208921000 creator A5032971030 @default.
• W3208921000 creator A5065718822 @default.
• W3208921000 creator A5069362726 @default.
• W3208921000 creator A5085745461 @default.
• W3208921000 creator A5090296262 @default.
• W3208921000 date "2021-10-01" @default.
• W3208921000 modified "2023-10-03" @default.
• W3208921000 title "Intimate Adhesion Is Essential for the Pathogen-Specific Inflammatory and Immune Responses in the Gut of Mice Infected with <i>Citrobacter rodentium</i>" @default.
• W3208921000 cites W1553007679 @default.
• W3208921000 cites W1876321204 @default.
• W3208921000 cites W1885357042 @default.
• W3208921000 cites W1888360831 @default.
• W3208921000 cites W1963633139 @default.
• W3208921000 cites W1979217507 @default.
• W3208921000 cites W1980580590 @default.
• W3208921000 cites W2008916405 @default.
• W3208921000 cites W2051347791 @default.
• W3208921000 cites W2059408709 @default.
• W3208921000 cites W2065214355 @default.
• W3208921000 cites W2067320696 @default.
• W3208921000 cites W2097957406 @default.
• W3208921000 cites W2100415806 @default.
• W3208921000 cites W2101994549 @default.
• W3208921000 cites W2102953537 @default.
• W3208921000 cites W2107369528 @default.
• W3208921000 cites W2111731663 @default.
• W3208921000 cites W2114475056 @default.
• W3208921000 cites W2123583755 @default.
• W3208921000 cites W2124346271 @default.
• W3208921000 cites W2138738692 @default.
• W3208921000 cites W2140577004 @default.
• W3208921000 cites W2155121556 @default.
• W3208921000 cites W2157116022 @default.
• W3208921000 cites W2167927725 @default.
• W3208921000 cites W2212304636 @default.
• W3208921000 cites W2512521740 @default.
• W3208921000 cites W2778660502 @default.
• W3208921000 cites W2894873183 @default.
• W3208921000 cites W2896358339 @default.
• W3208921000 cites W2904315613 @default.
• W3208921000 cites W2915271541 @default.
• W3208921000 cites W2973280955 @default.
• W3208921000 cites W3015287937 @default.
• W3208921000 doi "https://doi.org/10.4049/immunohorizons.2100087" @default.
• W3208921000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34702763" @default.
• W3208921000 hasPublicationYear "2021" @default.
• W3208921000 type Work @default.
• W3208921000 sameAs 3208921000 @default.
• W3208921000 citedByCount "2" @default.
• W3208921000 countsByYear W32089210002022 @default.
• W3208921000 countsByYear W32089210002023 @default.
• W3208921000 crossrefType "journal-article" @default.
• W3208921000 hasAuthorship W3208921000A5013900477 @default.
• W3208921000 hasAuthorship W3208921000A5032971030 @default.
• W3208921000 hasAuthorship W3208921000A5065718822 @default.
• W3208921000 hasAuthorship W3208921000A5069362726 @default.
• W3208921000 hasAuthorship W3208921000A5085745461 @default.
• W3208921000 hasAuthorship W3208921000A5090296262 @default.
• W3208921000 hasBestOaLocation W32089210001 @default.
• W3208921000 hasConcept C104317684 @default.
• W3208921000 hasConcept C118815799 @default.
• W3208921000 hasConcept C143065580 @default.
• W3208921000 hasConcept C179470777 @default.
• W3208921000 hasConcept C203014093 @default.
• W3208921000 hasConcept C2775945818 @default.
• W3208921000 hasConcept C2776460866 @default.
• W3208921000 hasConcept C2778910516 @default.
• W3208921000 hasConcept C2908821069 @default.
• W3208921000 hasConcept C2910319489 @default.
• W3208921000 hasConcept C547475151 @default.
• W3208921000 hasConcept C55493867 @default.
• W3208921000 hasConcept C60987743 @default.
• W3208921000 hasConcept C86803240 @default.
• W3208921000 hasConcept C8891405 @default.
• W3208921000 hasConcept C89423630 @default.
• W3208921000 hasConceptScore W3208921000C104317684 @default.
• W3208921000 hasConceptScore W3208921000C118815799 @default.
• W3208921000 hasConceptScore W3208921000C143065580 @default.
• W3208921000 hasConceptScore W3208921000C179470777 @default.
• W3208921000 hasConceptScore W3208921000C203014093 @default.
• W3208921000 hasConceptScore W3208921000C2775945818 @default.
• W3208921000 hasConceptScore W3208921000C2776460866 @default.
• W3208921000 hasConceptScore W3208921000C2778910516 @default.
• W3208921000 hasConceptScore W3208921000C2908821069 @default.
• W3208921000 hasConceptScore W3208921000C2910319489 @default.
• W3208921000 hasConceptScore W3208921000C547475151 @default.
• W3208921000 hasConceptScore W3208921000C55493867 @default.
• W3208921000 hasConceptScore W3208921000C60987743 @default.
• W3208921000 hasConceptScore W3208921000C86803240 @default.
• W3208921000 hasConceptScore W3208921000C8891405 @default.
• W3208921000 hasConceptScore W3208921000C89423630 @default.
• W3208921000 hasIssue "10" @default.
• W3208921000 hasLocation W32089210001 @default.
• W3208921000 hasLocation W32089210002 @default.
• W3208921000 hasOpenAccess W3208921000 @default.

• next