FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208923340> ?p ?o ?g. }

• W3208923340 endingPage "2149" @default.
• W3208923340 startingPage "2132" @default.
• W3208923340 abstract "The Homeobox B (HOXB) family promotes tumor progression, but the mechanism of its action in gastric cancer (GC) is unclear. We sought to identify the HOXB family members that are critical to the prognosis of GC patients.The Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), cBioPortal, UALCAN, Kaplan-Meier plotter, and the GeneMANIA databases were used to analyze the messenger RNA (mRNA) expression levels, prognostic value, and gene-gene interaction network of the HOXB9 family members in GC. The expression of HOXB9 in GC and its relationship with various clinicopathological parameters and the prognosis of patients were verified by immunohistochemistry.The expression of HOXB3, HOXB5, HOXB6, HOXB7, HOXB9, and HOXB13 mRNA was significantly upregulated in GC. There was a significant correlation between the upregulation of HOXB3, HOXB5, and HOXB9 mRNA and a low overall survival (OS) rate. The high expression of HOXB7, HOXB9, and HOXB13 mRNA was closely correlated to tumor grade and stage. HOXB9 was the HOXB family member most closely related to the occurrence and development of GC. A further analysis showed that HOXB9 might be involved in deoxyribonucleic acid repair and division regulation. A validation study showed that the advanced cancer group had a higher level of HOXB9 expression than the early cancer group. The high expression of HOXB9 in gastric tissue plays an important role in the survival and prognosis of GC patients.HOXB family members have different degrees of abnormal expression in GC. High HOXB9 expression in GC tissues was significantly correlated with a worse prognosis. Thus, HOXB9 is a potential novel biomarker and therapeutic target for GC." @default.
• W3208923340 created "2021-11-08" @default.
• W3208923340 creator A5018602458 @default.
• W3208923340 creator A5022748889 @default.
• W3208923340 creator A5024513713 @default.
• W3208923340 creator A5025270532 @default.
• W3208923340 creator A5032619594 @default.
• W3208923340 creator A5045121312 @default.
• W3208923340 creator A5050656936 @default.
• W3208923340 creator A5053778410 @default.
• W3208923340 creator A5074376468 @default.
• W3208923340 date "2021-10-01" @default.
• W3208923340 modified "2023-10-03" @default.
• W3208923340 title "Comprehensive bioinformatics analyses identified Homeobox B9 as a potential prognostic biomarker and therapeutic target for gastric cancer" @default.
• W3208923340 cites W1497102920 @default.
• W3208923340 cites W1812483684 @default.
• W3208923340 cites W1922567675 @default.
• W3208923340 cites W1978545732 @default.
• W3208923340 cites W1978587044 @default.
• W3208923340 cites W1985213868 @default.
• W3208923340 cites W1994447595 @default.
• W3208923340 cites W1997708982 @default.
• W3208923340 cites W2003215649 @default.
• W3208923340 cites W2017285791 @default.
• W3208923340 cites W2019542367 @default.
• W3208923340 cites W2020719897 @default.
• W3208923340 cites W2035122273 @default.
• W3208923340 cites W2039442394 @default.
• W3208923340 cites W2047061331 @default.
• W3208923340 cites W2052783034 @default.
• W3208923340 cites W2056506538 @default.
• W3208923340 cites W2059893763 @default.
• W3208923340 cites W2066171378 @default.
• W3208923340 cites W2082668371 @default.
• W3208923340 cites W2095320685 @default.
• W3208923340 cites W2101802836 @default.
• W3208923340 cites W2114759909 @default.
• W3208923340 cites W2114843025 @default.
• W3208923340 cites W2128024508 @default.
• W3208923340 cites W2128648434 @default.
• W3208923340 cites W2148270304 @default.
• W3208923340 cites W2150552506 @default.
• W3208923340 cites W2169961966 @default.
• W3208923340 cites W2170060925 @default.
• W3208923340 cites W2219978888 @default.
• W3208923340 cites W2255145384 @default.
• W3208923340 cites W2289845601 @default.
• W3208923340 cites W2338210288 @default.
• W3208923340 cites W2509733117 @default.
• W3208923340 cites W2539345857 @default.
• W3208923340 cites W2607129810 @default.
• W3208923340 cites W2616214073 @default.
• W3208923340 cites W2736730167 @default.
• W3208923340 cites W2785920133 @default.
• W3208923340 cites W2795209020 @default.
• W3208923340 cites W2889646458 @default.
• W3208923340 cites W2908372523 @default.
• W3208923340 cites W2912290257 @default.
• W3208923340 cites W2914625572 @default.
• W3208923340 cites W2917463838 @default.
• W3208923340 cites W2959503302 @default.
• W3208923340 cites W2968093290 @default.
• W3208923340 cites W2980179317 @default.
• W3208923340 cites W2989785723 @default.
• W3208923340 cites W2995790982 @default.
• W3208923340 cites W3006883765 @default.
• W3208923340 cites W3012243273 @default.
• W3208923340 cites W3039582646 @default.
• W3208923340 cites W3105900724 @default.
• W3208923340 doi "https://doi.org/10.21037/jgo-21-598" @default.
• W3208923340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8576221" @default.
• W3208923340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34790380" @default.
• W3208923340 hasPublicationYear "2021" @default.
• W3208923340 type Work @default.
• W3208923340 sameAs 3208923340 @default.
• W3208923340 citedByCount "0" @default.
• W3208923340 crossrefType "journal-article" @default.
• W3208923340 hasAuthorship W3208923340A5018602458 @default.
• W3208923340 hasAuthorship W3208923340A5022748889 @default.
• W3208923340 hasAuthorship W3208923340A5024513713 @default.
• W3208923340 hasAuthorship W3208923340A5025270532 @default.
• W3208923340 hasAuthorship W3208923340A5032619594 @default.
• W3208923340 hasAuthorship W3208923340A5045121312 @default.
• W3208923340 hasAuthorship W3208923340A5050656936 @default.
• W3208923340 hasAuthorship W3208923340A5053778410 @default.
• W3208923340 hasAuthorship W3208923340A5074376468 @default.
• W3208923340 hasBestOaLocation W32089233401 @default.
• W3208923340 hasConcept C104317684 @default.
• W3208923340 hasConcept C105580179 @default.
• W3208923340 hasConcept C121587040 @default.
• W3208923340 hasConcept C121608353 @default.
• W3208923340 hasConcept C126322002 @default.
• W3208923340 hasConcept C127561419 @default.
• W3208923340 hasConcept C143998085 @default.
• W3208923340 hasConcept C145059251 @default.
• W3208923340 hasConcept C150194340 @default.
• W3208923340 hasConcept C204232928 @default.
• W3208923340 hasConcept C2781197716 @default.

• next