Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208954814> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3208954814 abstract "Abstract Purpose : Non-invasive quantification of cerebral metabolic rate for glucose (CMRGlc) and characterizing cerebral metabolism of cerebrovascular territories are useful for the understanding of ischemic cerebrovascular disease (ICVD). Here, we proposed a non-invasive quantification approach based on image-derived input function (IDIF) suitable for ICVD patients and monitored the pathophysiological changes after surgical intervention. Methods : Sixteen healthy controls and 26 ischemic cerebrovascular disease patients with baseline and after surgical visits underwent 18 F-FDG PET/MR imaging. The voxel-wise CMRGlc maps were derived via our proposed IDIF method. The CMRGlc and standardized uptake value ratio (SUVR) maps were subsequently used to extract quantitative values within 7 volumes of interest (gray matter, white matter, anterior, middle, and posterior cerebral artery, basilar artery, and cerebellar artery territory). Intraclass correlation coefficient (ICC) and absolute percentage error were employed to measure consistency in healthy controls. The quantitative differences of healthy controls and patients at baseline and after surgical visits were statistically analyzed. Results : For healthy controls, there were no significant differences for region CMRGlc values across bilateral and unilateral IDIF measurements (ICC: 0.91-0.98). Significant differences in CMRGlc were observed across the cohorts in all territories ( P < 0.001). The CMRGlc values in the ipsilateral side were significantly increased after surgery intervention ( P < 0.05) for all territories (percentage changes: 7.4%~22.5%). Only the posterior cerebral artery and basilar artery territories (-2.8% and 1.9%) were significant differences for SUVR ( P < 0.05). The diagnostic ability of CMRGlc in various territories (area under curve: 0.923-0.966) was significantly higher than of SUVR. There was a significant association between CMRGlc with the national institutes of health stroke scores ( r : -0.54, P = 0.0041). Conclusion : These observations suggested the non-invasive quantification approach based on IDIF allowed the individual metabolism measurement of cerebrovascular territories after surgery and identified the glucose pathology changes underlying territories." @default.
- W3208954814 created "2021-11-08" @default.
- W3208954814 creator A5005344993 @default.
- W3208954814 creator A5009175141 @default.
- W3208954814 creator A5015102287 @default.
- W3208954814 creator A5017941498 @default.
- W3208954814 creator A5021557811 @default.
- W3208954814 creator A5028199007 @default.
- W3208954814 creator A5031043065 @default.
- W3208954814 creator A5048987419 @default.
- W3208954814 creator A5051547310 @default.
- W3208954814 creator A5065710231 @default.
- W3208954814 creator A5081693785 @default.
- W3208954814 creator A5083651238 @default.
- W3208954814 date "2021-10-18" @default.
- W3208954814 modified "2023-09-27" @default.
- W3208954814 title "A Noninvasive Quantification Approach for Monitoring Brain Metabolic Alterations After Surgical Intervention in Ischemic Cerebrovascular Disease" @default.
- W3208954814 doi "https://doi.org/10.21203/rs.3.rs-958601/v1" @default.
- W3208954814 hasPublicationYear "2021" @default.
- W3208954814 type Work @default.
- W3208954814 sameAs 3208954814 @default.
- W3208954814 citedByCount "0" @default.
- W3208954814 crossrefType "posted-content" @default.
- W3208954814 hasAuthorship W3208954814A5005344993 @default.
- W3208954814 hasAuthorship W3208954814A5009175141 @default.
- W3208954814 hasAuthorship W3208954814A5015102287 @default.
- W3208954814 hasAuthorship W3208954814A5017941498 @default.
- W3208954814 hasAuthorship W3208954814A5021557811 @default.
- W3208954814 hasAuthorship W3208954814A5028199007 @default.
- W3208954814 hasAuthorship W3208954814A5031043065 @default.
- W3208954814 hasAuthorship W3208954814A5048987419 @default.
- W3208954814 hasAuthorship W3208954814A5051547310 @default.
- W3208954814 hasAuthorship W3208954814A5065710231 @default.
- W3208954814 hasAuthorship W3208954814A5081693785 @default.
- W3208954814 hasAuthorship W3208954814A5083651238 @default.
- W3208954814 hasBestOaLocation W32089548141 @default.
- W3208954814 hasConcept C104709138 @default.
- W3208954814 hasConcept C126322002 @default.
- W3208954814 hasConcept C126838900 @default.
- W3208954814 hasConcept C143409427 @default.
- W3208954814 hasConcept C164705383 @default.
- W3208954814 hasConcept C171606756 @default.
- W3208954814 hasConcept C2775841333 @default.
- W3208954814 hasConcept C2777031167 @default.
- W3208954814 hasConcept C2781012200 @default.
- W3208954814 hasConcept C2781192897 @default.
- W3208954814 hasConcept C2989005 @default.
- W3208954814 hasConcept C541997718 @default.
- W3208954814 hasConcept C70410870 @default.
- W3208954814 hasConcept C71924100 @default.
- W3208954814 hasConceptScore W3208954814C104709138 @default.
- W3208954814 hasConceptScore W3208954814C126322002 @default.
- W3208954814 hasConceptScore W3208954814C126838900 @default.
- W3208954814 hasConceptScore W3208954814C143409427 @default.
- W3208954814 hasConceptScore W3208954814C164705383 @default.
- W3208954814 hasConceptScore W3208954814C171606756 @default.
- W3208954814 hasConceptScore W3208954814C2775841333 @default.
- W3208954814 hasConceptScore W3208954814C2777031167 @default.
- W3208954814 hasConceptScore W3208954814C2781012200 @default.
- W3208954814 hasConceptScore W3208954814C2781192897 @default.
- W3208954814 hasConceptScore W3208954814C2989005 @default.
- W3208954814 hasConceptScore W3208954814C541997718 @default.
- W3208954814 hasConceptScore W3208954814C70410870 @default.
- W3208954814 hasConceptScore W3208954814C71924100 @default.
- W3208954814 hasLocation W32089548141 @default.
- W3208954814 hasOpenAccess W3208954814 @default.
- W3208954814 hasPrimaryLocation W32089548141 @default.
- W3208954814 hasRelatedWork W2045893060 @default.
- W3208954814 hasRelatedWork W2048713437 @default.
- W3208954814 hasRelatedWork W2094707199 @default.
- W3208954814 hasRelatedWork W2097818544 @default.
- W3208954814 hasRelatedWork W2374738994 @default.
- W3208954814 hasRelatedWork W2383436488 @default.
- W3208954814 hasRelatedWork W2384497422 @default.
- W3208954814 hasRelatedWork W2595846231 @default.
- W3208954814 hasRelatedWork W2810702825 @default.
- W3208954814 hasRelatedWork W4319008053 @default.
- W3208954814 isParatext "false" @default.
- W3208954814 isRetracted "false" @default.
- W3208954814 magId "3208954814" @default.
- W3208954814 workType "article" @default.