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- W3208956140 abstract "Hepatocellular carcinoma (HCC) is the major subtype of liver cancer, showing high mortality of patients due to limited therapeutic options at advanced stages of disease. The receptor tyrosine kinases Tyro3, Axl and MerTK-belonging to the TAM family-exert a large impact on various aspects of cancer biology. Binding of the ligands Gas6 or Protein S activates TAM receptors causing homophilic dimerization and heterophilic interactions with other receptors to modulate effector functions. In this context, TAM receptors are major regulators of anti-inflammatory responses and vessel integrity, including platelet aggregation as well as resistance to chemotherapy. In this review, we discuss the relevance of TAM receptors in the intrinsic control of HCC progression by modulating epithelial cell plasticity and by promoting metastatic traits of neoplastic hepatocytes. Depending on different etiologies of HCC, we further describe the overt role of TAM receptors in the extrinsic control of HCC progression by focusing on immune cell infiltration and fibrogenesis. Additionally, we assess TAM receptor functions in the chemoresistance against clinically used tyrosine kinase inhibitors and immune checkpoint blockade in HCC progression. We finally address the question of whether inhibition of TAM receptors can be envisaged for novel therapeutic strategies in HCC." @default.
- W3208956140 created "2021-11-08" @default.
- W3208956140 creator A5017079649 @default.
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- W3208956140 creator A5066055526 @default.
- W3208956140 creator A5085988278 @default.
- W3208956140 date "2021-10-29" @default.
- W3208956140 modified "2023-10-16" @default.
- W3208956140 title "Intrinsic and Extrinsic Control of Hepatocellular Carcinoma by TAM Receptors" @default.
- W3208956140 cites W1486743716 @default.
- W3208956140 cites W1501918566 @default.
- W3208956140 cites W1590094217 @default.
- W3208956140 cites W1607701774 @default.
- W3208956140 cites W1808840955 @default.
- W3208956140 cites W1856137242 @default.
- W3208956140 cites W1876403508 @default.
- W3208956140 cites W1971602395 @default.
- W3208956140 cites W1980673019 @default.
- W3208956140 cites W1983894470 @default.
- W3208956140 cites W1984350114 @default.
- W3208956140 cites W1991710539 @default.
- W3208956140 cites W1992481999 @default.
- W3208956140 cites W2000384057 @default.
- W3208956140 cites W2000641839 @default.
- W3208956140 cites W2007775311 @default.
- W3208956140 cites W2014647718 @default.
- W3208956140 cites W2022270308 @default.
- W3208956140 cites W2024153547 @default.
- W3208956140 cites W2025879648 @default.
- W3208956140 cites W2027615892 @default.
- W3208956140 cites W2030113633 @default.
- W3208956140 cites W2037606194 @default.
- W3208956140 cites W2038122505 @default.
- W3208956140 cites W2040685978 @default.
- W3208956140 cites W2043642782 @default.
- W3208956140 cites W2046791164 @default.
- W3208956140 cites W2050239232 @default.
- W3208956140 cites W2050593322 @default.
- W3208956140 cites W2051692881 @default.
- W3208956140 cites W2053491138 @default.
- W3208956140 cites W2056010443 @default.
- W3208956140 cites W2056307371 @default.
- W3208956140 cites W2062581217 @default.
- W3208956140 cites W2064662152 @default.
- W3208956140 cites W2066376483 @default.
- W3208956140 cites W2071709107 @default.
- W3208956140 cites W2074604431 @default.
- W3208956140 cites W2077999696 @default.
- W3208956140 cites W2079075723 @default.
- W3208956140 cites W2080044333 @default.
- W3208956140 cites W2081115093 @default.
- W3208956140 cites W2081259798 @default.
- W3208956140 cites W2082374903 @default.
- W3208956140 cites W2083870593 @default.
- W3208956140 cites W2086177031 @default.
- W3208956140 cites W2088565779 @default.
- W3208956140 cites W2088904620 @default.
- W3208956140 cites W2094197540 @default.
- W3208956140 cites W2106549878 @default.
- W3208956140 cites W2119710439 @default.
- W3208956140 cites W2120648280 @default.
- W3208956140 cites W2126232334 @default.
- W3208956140 cites W2130636524 @default.
- W3208956140 cites W2132626958 @default.
- W3208956140 cites W2137562588 @default.
- W3208956140 cites W2137713702 @default.
- W3208956140 cites W2139380919 @default.
- W3208956140 cites W2149014007 @default.
- W3208956140 cites W2151305493 @default.
- W3208956140 cites W2153043340 @default.
- W3208956140 cites W2153566723 @default.
- W3208956140 cites W2155663509 @default.
- W3208956140 cites W2162436188 @default.
- W3208956140 cites W2162486777 @default.
- W3208956140 cites W2169105660 @default.
- W3208956140 cites W2175330263 @default.
- W3208956140 cites W2177466111 @default.
- W3208956140 cites W2202338600 @default.
- W3208956140 cites W2289068089 @default.
- W3208956140 cites W2297865359 @default.
- W3208956140 cites W2328509703 @default.
- W3208956140 cites W2346898981 @default.
- W3208956140 cites W2407812106 @default.
- W3208956140 cites W2429598685 @default.
- W3208956140 cites W2497059924 @default.
- W3208956140 cites W2524717494 @default.
- W3208956140 cites W2530391744 @default.
- W3208956140 cites W2559860369 @default.
- W3208956140 cites W2593588874 @default.
- W3208956140 cites W2606367731 @default.
- W3208956140 cites W2611952635 @default.
- W3208956140 cites W2624831627 @default.
- W3208956140 cites W2626033245 @default.
- W3208956140 cites W2738403240 @default.
- W3208956140 cites W2765877698 @default.
- W3208956140 cites W2772781697 @default.
- W3208956140 cites W2782485041 @default.