FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3208982904> ?p ?o ?g. }

• W3208982904 endingPage "S788" @default.
• W3208982904 startingPage "S788" @default.
• W3208982904 abstract "Introduction: Breast cancer is the most common malignancy in women in the United States and the second leading cause of cancer death. Most common sites of metastases are the lungs, liver, brain and skeleton. Our case describes a patient with invasive lobular carcinoma (ILC) of the breast that metastasized to the colon which presented without gastrointestinal symptoms or exophytic masses on colonoscopy but rather diaphragmatic concentric structuring within the distal colon. Case Description/Methods: A 68-year-old female with recently diagnosed ILC now status post bilateral mastectomy and currently undergoing chemotherapy presented for repeat serial positron emission tomography/computed tomography (PET/CT) for her skeletal and skin metastases. It demonstrated new hypermetabolic activity in the colon and bowel wall thickening. She denied constipation, diarrhea, abdominal pain, nausea, melena, hematochezia, and averaged 1-2 bowel movements per day. She was then taken for colonoscopy which revealing a diaphragm-like stricture at 20cm of scope insertion, which the pediatric colonoscope was unable to traverse. A stricture scope was then used to advance to the splenic flexure with findings of two additional diaphragm-like strictures at 25cm and 40cm, all with normal intervening colonic mucosa. There were no exophytic masses found during the procedure. Biopsies were obtained from each of the three colonic strictures which showed infiltrative cells in the submucosa that highlighted with GATA-3 and p120 stains, an immunophenotype consistent with metastatic lobular breast carcinoma. She was referred to the colorectal surgeon for possible ostomy formation, but due to lack of obstructive symptoms, deferred surgery and opted for prophylactic medical management of constipation. Discussion: Breast cancer is common malignancy in women however metastasis to the colon is rare. Of these, most present as exophytic masses and present with symptoms of obstruction. A possible explanation of the unusual presentation in this case involves the mechanism of metastasis. The main pathway of distant breast cancer metastasis is via hematogenous spread. 80% of colonic blood flow perfuses mucosal and submucosal layers with only 20% supplying the muscularis layer. If however there was metastasis within the muscularis layer it would allow for circumferential growth with gradual invasion and stenosis leading to stricturing as appreciated in this case.Figure 1.: (A) Endoscopic view of the 20cm colonic diaphragmatic stricture showing normal overlying mucosa without erythema or exophytic mass. (B) Endoscopic view of the 25cm colonic stricture. (C) Endoscopic view of the 40cm colonic stricture after biopsy was taken at the 3 o’clock position." @default.
• W3208982904 created "2021-11-08" @default.
• W3208982904 creator A5015285213 @default.
• W3208982904 creator A5066142195 @default.
• W3208982904 date "2021-10-01" @default.
• W3208982904 modified "2023-09-26" @default.
• W3208982904 title "S1785 The Lord of the Rings: A Rare Endoscopic Presentation of Metastatic Breast Cancer to the Colon" @default.
• W3208982904 doi "https://doi.org/10.14309/01.ajg.0000780672.62961.ea" @default.
• W3208982904 hasPublicationYear "2021" @default.
• W3208982904 type Work @default.
• W3208982904 sameAs 3208982904 @default.
• W3208982904 citedByCount "0" @default.
• W3208982904 crossrefType "journal-article" @default.
• W3208982904 hasAuthorship W3208982904A5015285213 @default.
• W3208982904 hasAuthorship W3208982904A5066142195 @default.
• W3208982904 hasBestOaLocation W32089829041 @default.
• W3208982904 hasConcept C121608353 @default.
• W3208982904 hasConcept C126322002 @default.
• W3208982904 hasConcept C126838900 @default.
• W3208982904 hasConcept C141071460 @default.
• W3208982904 hasConcept C2775930923 @default.
• W3208982904 hasConcept C2777424391 @default.
• W3208982904 hasConcept C2777807078 @default.
• W3208982904 hasConcept C2778435480 @default.
• W3208982904 hasConcept C2779052585 @default.
• W3208982904 hasConcept C2781054515 @default.
• W3208982904 hasConcept C526805850 @default.
• W3208982904 hasConcept C530470458 @default.
• W3208982904 hasConcept C71924100 @default.
• W3208982904 hasConceptScore W3208982904C121608353 @default.
• W3208982904 hasConceptScore W3208982904C126322002 @default.
• W3208982904 hasConceptScore W3208982904C126838900 @default.
• W3208982904 hasConceptScore W3208982904C141071460 @default.
• W3208982904 hasConceptScore W3208982904C2775930923 @default.
• W3208982904 hasConceptScore W3208982904C2777424391 @default.
• W3208982904 hasConceptScore W3208982904C2777807078 @default.
• W3208982904 hasConceptScore W3208982904C2778435480 @default.
• W3208982904 hasConceptScore W3208982904C2779052585 @default.
• W3208982904 hasConceptScore W3208982904C2781054515 @default.
• W3208982904 hasConceptScore W3208982904C526805850 @default.
• W3208982904 hasConceptScore W3208982904C530470458 @default.
• W3208982904 hasConceptScore W3208982904C71924100 @default.
• W3208982904 hasIssue "1" @default.
• W3208982904 hasLocation W32089829041 @default.
• W3208982904 hasLocation W32089829042 @default.
• W3208982904 hasOpenAccess W3208982904 @default.
• W3208982904 hasPrimaryLocation W32089829041 @default.
• W3208982904 hasRelatedWork W2036346458 @default.
• W3208982904 hasRelatedWork W2043525110 @default.
• W3208982904 hasRelatedWork W2053800163 @default.
• W3208982904 hasRelatedWork W2363611241 @default.
• W3208982904 hasRelatedWork W2920922904 @default.
• W3208982904 hasRelatedWork W2977928080 @default.
• W3208982904 hasRelatedWork W2979384051 @default.
• W3208982904 hasRelatedWork W3022325076 @default.
• W3208982904 hasRelatedWork W4226188970 @default.
• W3208982904 hasRelatedWork W4291632935 @default.
• W3208982904 hasVolume "116" @default.
• W3208982904 isParatext "false" @default.
• W3208982904 isRetracted "false" @default.
• W3208982904 magId "3208982904" @default.
• W3208982904 workType "article" @default.