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- W3209011065 abstract "Three silver(I) dipeptide complexes [Ag(GlyGly)]n(NO3)n (AgGlyGly), [Ag2(GlyAla)(NO3)2]n (AgGlyAla) and [Ag2(HGlyAsp)(NO3)]n (AgGlyAsp) were prepared, investigated and characterized by vibrational spectroscopy (mid-IR), elemental and thermogravimetric analysis and mass spectrometry. For AgGlyGly, X-ray crystallography was also performed. Their stability in biological testing media was verified by time-dependent NMR measurements. Their in vitro antimicrobial activity was evaluated against selected pathogenic microorganisms. Moreover, the influence of silver(I) dipeptide complexes on microbial film formation was described. Further, the cytotoxicity of the complexes against selected cancer cells (BLM, MDA-MB-231, HeLa, HCT116, MCF-7 and Jurkat) and fibroblasts (BJ-5ta) using a colorimetric MTS assay was tested, and the selectivity index (SI) was identified. The mechanism of action of Ag(I) dipeptide complexes was elucidated and discussed by the study in terms of their binding affinity toward the CT DNA, the ability to cleave the DNA and the ability to influence numbers of cells within each cell cycle phase. The new silver(I) dipeptide complexes are able to bind into DNA by noncovalent interaction, and the topoisomerase I inhibition study showed that the studied complexes inhibit its activity at a concentration of 15 μM." @default.
- W3209011065 created "2021-11-08" @default.
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- W3209011065 date "2021-10-20" @default.
- W3209011065 modified "2023-10-17" @default.
- W3209011065 title "Antimicrobial and Anticancer Application of Silver(I) Dipeptide Complexes" @default.
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- W3209011065 cites W1968270266 @default.
- W3209011065 cites W1969360633 @default.
- W3209011065 cites W1969882457 @default.
- W3209011065 cites W1979461355 @default.
- W3209011065 cites W1982504159 @default.
- W3209011065 cites W2003264987 @default.
- W3209011065 cites W2005156172 @default.
- W3209011065 cites W2007758575 @default.
- W3209011065 cites W2016836200 @default.
- W3209011065 cites W2022145641 @default.
- W3209011065 cites W2029694127 @default.
- W3209011065 cites W2029839359 @default.
- W3209011065 cites W2030094790 @default.
- W3209011065 cites W2041051519 @default.
- W3209011065 cites W2042429567 @default.
- W3209011065 cites W2047470558 @default.
- W3209011065 cites W2059877588 @default.
- W3209011065 cites W2068747157 @default.
- W3209011065 cites W2083194796 @default.
- W3209011065 cites W2088695864 @default.
- W3209011065 cites W2090145683 @default.
- W3209011065 cites W2091082839 @default.
- W3209011065 cites W2092555653 @default.
- W3209011065 cites W2092781196 @default.
- W3209011065 cites W2094083551 @default.
- W3209011065 cites W2129707272 @default.
- W3209011065 cites W2132600317 @default.
- W3209011065 cites W2132770707 @default.
- W3209011065 cites W2138283022 @default.
- W3209011065 cites W2139851375 @default.
- W3209011065 cites W2142144313 @default.
- W3209011065 cites W2147157934 @default.
- W3209011065 cites W2159936883 @default.
- W3209011065 cites W2167992230 @default.
- W3209011065 cites W2168148418 @default.
- W3209011065 cites W2172461098 @default.
- W3209011065 cites W2178317910 @default.
- W3209011065 cites W2238656217 @default.
- W3209011065 cites W2313115260 @default.
- W3209011065 cites W2319902168 @default.
- W3209011065 cites W2324832570 @default.
- W3209011065 cites W2410538093 @default.
- W3209011065 cites W2417101811 @default.
- W3209011065 cites W2511590400 @default.
- W3209011065 cites W2561355596 @default.
- W3209011065 cites W2597804087 @default.
- W3209011065 cites W2737565163 @default.
- W3209011065 cites W2753589076 @default.
- W3209011065 cites W2767374339 @default.
- W3209011065 cites W2771607042 @default.
- W3209011065 cites W2788308864 @default.
- W3209011065 cites W2809256531 @default.
- W3209011065 cites W2884126009 @default.
- W3209011065 cites W2898534129 @default.
- W3209011065 cites W2901328088 @default.
- W3209011065 cites W2907020807 @default.
- W3209011065 cites W2913465179 @default.
- W3209011065 cites W2938769668 @default.
- W3209011065 cites W2972782015 @default.
- W3209011065 cites W2990285796 @default.
- W3209011065 cites W2997131071 @default.
- W3209011065 cites W3012390987 @default.
- W3209011065 cites W3012627303 @default.
- W3209011065 cites W3036713553 @default.
- W3209011065 cites W3039045832 @default.
- W3209011065 cites W3094515853 @default.
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- W3209011065 cites W3163225669 @default.
- W3209011065 cites W412154558 @default.
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- W3209011065 doi "https://doi.org/10.3390/molecules26216335" @default.
- W3209011065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8587849" @default.
- W3209011065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34770744" @default.
- W3209011065 hasPublicationYear "2021" @default.
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