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- W3209014098 startingPage "297" @default.
- W3209014098 abstract "Sensory neurons are modulated by context. For example, in mouse primary visual cortex (V1), neuronal responses to the preferred orientation are modulated by the presence of superimposed orientations (plaids). The effects of this modulation are diverse; some neurons are suppressed, while others have larger responses to a plaid than its components. We investigated whether this diversity could be explained by a unified circuit mechanism. We report that this masking is maintained during suppression of cortical activity, arguing against cortical mechanisms. Instead, the heterogeneity of plaid responses is explained by an interaction between stimulus geometry and orientation tuning. Highly selective neurons are uniformly suppressed by plaids, whereas the effects in weakly selective neurons depend on the spatial configuration of the stimulus, transitioning systematically between suppression and facilitation. Thus, the diverse responses emerge as a consequence of the spatial structure of feedforward inputs, with no need to invoke cortical interactions." @default.
- W3209014098 created "2021-11-08" @default.
- W3209014098 creator A5004043467 @default.
- W3209014098 creator A5016733808 @default.
- W3209014098 creator A5039365254 @default.
- W3209014098 date "2022-01-01" @default.
- W3209014098 modified "2023-10-17" @default.
- W3209014098 title "Feedforward mechanisms of cross-orientation interactions in mouse V1" @default.
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- W3209014098 doi "https://doi.org/10.1016/j.neuron.2021.10.017" @default.
- W3209014098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34735779" @default.
- W3209014098 hasPublicationYear "2022" @default.
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