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- W3209036724 abstract "A 47-year-old woman suffered from increasing pain caused by multiple subcutaneous hard nodules, which have been interrupting her daily activities in the long-term. It was hard for her to lie supine, walk upright or reach objects. She had a 9-year history of clinically amyopathic dermatomyositis (CADM) confirmed by Gottron’s papules previously, anti-MDA5 antibodies positivity and biopsy. Physical examination showed multiple tender nodules depositing around her elbows and buttocks (Fig.1A and B). The thigh felt cold and stiff (Fig.1C). Biopsy of skin and subcutaneous fascia revealed basophilic deposits of calcium salts (Fig. 1D). X-ray confirmed multiple subcutaneous calcifications in soft tissues around elbow joints, thighs, buttocks and hip joints. General muscle outlines of biceps, gracilius, adductor longus, vastus internus and tensor fascia were obvious in the radiographs due to extensive calcinosis in the deep myofascial (Fig. 1E and F). Complication secondary to calcinosis includes local pain, skin ulcer and secondary skin infection and so on [1]. To our knowledge, there has been no previous report of extensive myofascia calcinosis owing to adult DM involving the critical skeletal muscle groups leading to extremity disability. Besides this, anti-MDA5 antibody, CADM and myofascia-dominant involvement may be highly regarded as independent risk factors for developing rapidly progressive interstitial lung disease [2]. However, the patient has not yet developed rapidly progressive interstitial pneumonia." @default.
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- W3209036724 date "2021-11-03" @default.
- W3209036724 modified "2023-09-27" @default.
- W3209036724 title "Extensive myofascia calcinosis in an adult patient with amyopathic dermatomyositis" @default.
- W3209036724 doi "https://doi.org/10.1093/rheumatology/keab821" @default.
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