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• W3209039745 abstract "AbstractThe G matrix is a statistical summary of the genetic basis of a set of traits and a central pillar of quantitative genetics. A persistent controversy is whether G changes slowly or quickly over time. The evolution of G is important because it affects the ability to predict, or reconstruct, evolution by selection. Empirical studies have found mixed results on how fast G evolves. Theoretical work has largely been developed under the assumption that the relationship between genetic variation and phenotypic variation-the genotype-phenotype map (GPM)-is linear. Under this assumption, G is expected to remain constant over long periods of time. However, according to developmental biology, the GPM is typically complex and nonlinear. Here, we use a GPM model based on the development of a multicellular organ to study how G evolves. We find that G can change relatively fast and in qualitative different ways, which we describe in detail. Changes can be particularly large when the population crosses between regions of the GPM that have different properties. This can result in the additive genetic variance in the direction of selection fluctuating over time and even increasing despite the eroding effect of selection." @default.
• W3209039745 created "2021-11-08" @default.
• W3209039745 creator A5025275078 @default.
• W3209039745 creator A5090106824 @default.
• W3209039745 date "2022-03-01" @default.
• W3209039745 modified "2023-10-15" @default.
• W3209039745 title "Evolution of the <i>G</i> Matrix under Nonlinear Genotype-Phenotype Maps" @default.
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• W3209039745 doi "https://doi.org/10.1086/717814" @default.
• W3209039745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35175900" @default.
• W3209039745 hasPublicationYear "2022" @default.
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