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- W3209044094 abstract "Transcription factors (TFs) play an important role in tumors. We integrated and analyzed 13 GPL570 platform gastric cancer (GC) microarrays, identified 10 independent prognostic TFs, and constructed a GC prognostic model. Using GSE26942 as the verification set, the Kaplan-Meier curve showed that the signature distinguish the survival rate of GC patients (P < 0.01), and the AUC values are 0.746 and 0.630, respectively. Compared with the clinicopathological characteristics, the signature is an independent prognostic factor (P < 0.05). A nomogram was established based on the model, and the five-year calibration curve verified that the prediction of the nomogram was almost consistent with the actual survival rate, C-index of 0.747 indicated a moderate prognostic ability. The analysis of target genes of 10 TFs showed that they are closely related to the progression of GC. External database and rt-PCR showed that the RNA and protein expression of TFs are consistent with our analysis." @default.
- W3209044094 created "2021-11-08" @default.
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- W3209044094 date "2021-10-01" @default.
- W3209044094 modified "2023-10-18" @default.
- W3209044094 title "Establishment of a prognostic model of ten transcription factors in gastric cancer" @default.
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- W3209044094 doi "https://doi.org/10.1016/j.ygeno.2021.10.009" @default.
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