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• W3209046513 abstract "Proteins’ tendency to form stable complexes in a highly specific manner is essential to all biological processes. Accurate identification of key residues participating in complex formation is critical for the rational design of therapeutic agents that can fine-tune protein–protein interactions. However, finding critical interfaces of a protein complex in a biological context is challenging due to the lack of relevant technologies. Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas nuclease is a powerful tool for genome editing. Specifically, CRISPR tiling is a more recent application of the CRISPR-Cas system that offers a toolkit to identify the functional elements within the noncoding genome and to reveal the critical interfaces of a protein complex in a physiological context. The identification of critical interfaces of disease-associated protein complexes has an enormous potential in drug discovery. Here, we review the technique of CRISPR-tiling–mediated mutagenesis as a mechanism to uncover critical interfaces of a target complex and discuss practical aspects of CRISPR-tiling library design and screen analysis." @default.
• W3209046513 created "2021-11-08" @default.
• W3209046513 creator A5019014285 @default.
• W3209046513 date "2022-01-01" @default.
• W3209046513 modified "2023-10-02" @default.
• W3209046513 title "CRISPR-mediated dense mutagenesis: a tool for rational targeting of multiprotein complexes and the noncoding genome" @default.
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• W3209046513 doi "https://doi.org/10.1016/b978-0-12-817876-8.00004-8" @default.
• W3209046513 hasPublicationYear "2022" @default.
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