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• W3209047178 abstract "Polycyclic aromatic hydrocarbons (PAHs) are among the most toxic and bioavailable components found in petroleum and represent a high risk to aquatic organisms. The aryl hydrocarbon receptor (Ahr) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other planar aromatic hydrocarbons, including certain PAHs. Ahr acts as a xenosensor and modulates the transcription of biotransformation genes in vertebrates, such as cytochrome P450 1A (cyp1a). Atlantic cod (Gadus morhua) possesses two Ahr proteins, Ahr1a and Ahr2a, which diverge in their primary structure, tissue-specific expression, ligand affinities, and transactivation profiles. Here, a luciferase reporter gene assay was used to assess the sensitivity of the Atlantic cod Ahrs to 31 polycyclic aromatic compounds (PACs), including two- to five-ring native PAHs, a sulfur-containing heterocyclic PAC, as well as several methylated, methoxylated, and hydroxylated congeners. Notably, most parent compounds, including naphthalene, phenanthrene, and partly, chrysene, did not act as agonists for the Ahrs, while hydroxylated and/or alkylated versions of these PAHs were potent agonists. Importantly, the greater potencies of substituted PAH derivatives and their ubiquitous occurrence in nature emphasize that more knowledge on the toxicity of these environmentally and toxicologically relevant compounds is imperative." @default.
• W3209047178 created "2021-11-08" @default.
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• W3209047178 creator A5047098902 @default.
• W3209047178 date "2021-11-05" @default.
• W3209047178 modified "2023-10-15" @default.
• W3209047178 title "Substituted Two- to Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (<i>Gadus morhua</i>) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a" @default.
• W3209047178 cites W1540016031 @default.
• W3209047178 cites W1600320801 @default.
• W3209047178 cites W1720231650 @default.
• W3209047178 cites W1863067409 @default.
• W3209047178 cites W1878017398 @default.
• W3209047178 cites W1965459058 @default.
• W3209047178 cites W1966594837 @default.
• W3209047178 cites W1970970217 @default.
• W3209047178 cites W1974629531 @default.
• W3209047178 cites W1980211217 @default.
• W3209047178 cites W1983613007 @default.
• W3209047178 cites W1986044147 @default.
• W3209047178 cites W1990131329 @default.
• W3209047178 cites W1997602332 @default.
• W3209047178 cites W2000155641 @default.
• W3209047178 cites W2000448208 @default.
• W3209047178 cites W2007529733 @default.
• W3209047178 cites W2009139159 @default.
• W3209047178 cites W2014407914 @default.
• W3209047178 cites W2016294543 @default.
• W3209047178 cites W2020792897 @default.
• W3209047178 cites W2026525652 @default.
• W3209047178 cites W2031763470 @default.
• W3209047178 cites W2034011659 @default.
• W3209047178 cites W2045777771 @default.
• W3209047178 cites W2047571907 @default.
• W3209047178 cites W2048244792 @default.
• W3209047178 cites W2049084155 @default.
• W3209047178 cites W2050665923 @default.
• W3209047178 cites W2056134325 @default.
• W3209047178 cites W2056515960 @default.
• W3209047178 cites W2059569676 @default.
• W3209047178 cites W2061416324 @default.
• W3209047178 cites W2064179251 @default.
• W3209047178 cites W2070617809 @default.
• W3209047178 cites W2071235682 @default.
• W3209047178 cites W2075310695 @default.
• W3209047178 cites W2077729621 @default.
• W3209047178 cites W2086843187 @default.
• W3209047178 cites W2087751655 @default.
• W3209047178 cites W2088092210 @default.
• W3209047178 cites W2092105148 @default.
• W3209047178 cites W2092394703 @default.
• W3209047178 cites W2096093439 @default.
• W3209047178 cites W2097360502 @default.
• W3209047178 cites W2098094407 @default.
• W3209047178 cites W2108970858 @default.
• W3209047178 cites W2118744236 @default.
• W3209047178 cites W2119291055 @default.
• W3209047178 cites W2122188118 @default.
• W3209047178 cites W2125985347 @default.
• W3209047178 cites W2126855665 @default.
• W3209047178 cites W2150109695 @default.
• W3209047178 cites W2156828620 @default.
• W3209047178 cites W2157906581 @default.
• W3209047178 cites W2165796738 @default.
• W3209047178 cites W2171566433 @default.
• W3209047178 cites W2173074205 @default.
• W3209047178 cites W2330781253 @default.
• W3209047178 cites W2372218838 @default.
• W3209047178 cites W2401589159 @default.
• W3209047178 cites W2401923946 @default.
• W3209047178 cites W2480164384 @default.
• W3209047178 cites W2502133115 @default.
• W3209047178 cites W2579458543 @default.
• W3209047178 cites W2584770468 @default.
• W3209047178 cites W2616232958 @default.
• W3209047178 cites W2620969030 @default.
• W3209047178 cites W2734461320 @default.
• W3209047178 cites W2766336051 @default.
• W3209047178 cites W2782664750 @default.
• W3209047178 cites W2794037110 @default.
• W3209047178 cites W2806313121 @default.
• W3209047178 cites W2913510670 @default.
• W3209047178 cites W2943293186 @default.
• W3209047178 cites W2945287161 @default.
• W3209047178 cites W2950875003 @default.
• W3209047178 cites W2964308649 @default.
• W3209047178 cites W2996417638 @default.
• W3209047178 cites W3024621471 @default.
• W3209047178 cites W3038146929 @default.
• W3209047178 cites W3094478882 @default.
• W3209047178 cites W55016974 @default.
• W3209047178 cites W65938566 @default.
• W3209047178 doi "https://doi.org/10.1021/acs.est.1c02946" @default.
• W3209047178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8600679" @default.
• W3209047178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34739213" @default.

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