FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209055387> ?p ?o ?g. }

• W3209055387 abstract "Alzheimer's disease (AD) is the most common cause of senile dementia. Although AD research has made important breakthroughs, the pathogenesis of this disease remains unclear, and specific AD diagnostic biomarkers and therapeutic strategies are still lacking. Recent studies have demonstrated that neuroinflammation is involved in AD pathogenesis and is closely related to other health effects. MicroRNAs (miRNAs) are a class of endogenous short sequence non-coding RNAs that indirectly inhibit translation or directly degrade messenger RNA (mRNA) by specifically binding to its 3' untranslated region (UTR). Several broadly expressed miRNAs including miR-21, miR-146a, and miR-155, have now been shown to regulate microglia/astrocytes activation. Other miRNAs, including miR-126 and miR-132, show a progressive link to the neuroinflammatory signaling. Therefore, further studies on these inflamma-miRNAs may shed light on the pathological mechanisms of AD. The differential expression of inflamma-miRNAs (such as miR-29a, miR-125b, and miR-126-5p) in the peripheral circulation may respond to AD progression, similar to inflammation, and therefore may become potential diagnostic biomarkers for AD. Moreover, inflamma-miRNAs could also be promising therapeutic targets for AD treatment. This review provides insights into the role of inflamma-miRNAs in AD, as well as an overview of general inflamma-miRNA biology, their implications in pathophysiology, and their potential roles as biomarkers and therapeutic targets." @default.
• W3209055387 created "2021-11-08" @default.
• W3209055387 creator A5053275663 @default.
• W3209055387 creator A5068939748 @default.
• W3209055387 date "2021-10-28" @default.
• W3209055387 modified "2023-10-16" @default.
• W3209055387 title "Inflamma-MicroRNAs in Alzheimer’s Disease: From Disease Pathogenesis to Therapeutic Potentials" @default.
• W3209055387 cites W1530195336 @default.
• W3209055387 cites W1555289101 @default.
• W3209055387 cites W1639853587 @default.
• W3209055387 cites W1833918098 @default.
• W3209055387 cites W1902711869 @default.
• W3209055387 cites W1920972969 @default.
• W3209055387 cites W1965152588 @default.
• W3209055387 cites W1972958690 @default.
• W3209055387 cites W1988163167 @default.
• W3209055387 cites W1993905300 @default.
• W3209055387 cites W1998381550 @default.
• W3209055387 cites W1998965915 @default.
• W3209055387 cites W2010597994 @default.
• W3209055387 cites W2015681531 @default.
• W3209055387 cites W2018708829 @default.
• W3209055387 cites W2025199750 @default.
• W3209055387 cites W2025567420 @default.
• W3209055387 cites W2026286990 @default.
• W3209055387 cites W2026581189 @default.
• W3209055387 cites W2033105784 @default.
• W3209055387 cites W2037414479 @default.
• W3209055387 cites W2039551908 @default.
• W3209055387 cites W2039794526 @default.
• W3209055387 cites W2044510533 @default.
• W3209055387 cites W2049623023 @default.
• W3209055387 cites W2049772720 @default.
• W3209055387 cites W2055776709 @default.
• W3209055387 cites W2065367532 @default.
• W3209055387 cites W2065566217 @default.
• W3209055387 cites W2068872788 @default.
• W3209055387 cites W2069121057 @default.
• W3209055387 cites W2072087961 @default.
• W3209055387 cites W2075860675 @default.
• W3209055387 cites W2079294041 @default.
• W3209055387 cites W2080225612 @default.
• W3209055387 cites W2082414904 @default.
• W3209055387 cites W2084062482 @default.
• W3209055387 cites W2087032228 @default.
• W3209055387 cites W2087243986 @default.
• W3209055387 cites W2088685810 @default.
• W3209055387 cites W2089107286 @default.
• W3209055387 cites W2090450186 @default.
• W3209055387 cites W2091386155 @default.
• W3209055387 cites W2095876795 @default.
• W3209055387 cites W2112513114 @default.
• W3209055387 cites W2113401494 @default.
• W3209055387 cites W2117472344 @default.
• W3209055387 cites W2118028558 @default.
• W3209055387 cites W2120522615 @default.
• W3209055387 cites W2124478244 @default.
• W3209055387 cites W2124816777 @default.
• W3209055387 cites W2125386008 @default.
• W3209055387 cites W2129267808 @default.
• W3209055387 cites W2132281111 @default.
• W3209055387 cites W2133096503 @default.
• W3209055387 cites W2146042550 @default.
• W3209055387 cites W2148477576 @default.
• W3209055387 cites W2154471162 @default.
• W3209055387 cites W2159268524 @default.
• W3209055387 cites W2170899856 @default.
• W3209055387 cites W2237598232 @default.
• W3209055387 cites W2294344816 @default.
• W3209055387 cites W2295603197 @default.
• W3209055387 cites W2322565284 @default.
• W3209055387 cites W2328179859 @default.
• W3209055387 cites W2471068437 @default.
• W3209055387 cites W2508205230 @default.
• W3209055387 cites W2514258009 @default.
• W3209055387 cites W2538708794 @default.
• W3209055387 cites W2548821687 @default.
• W3209055387 cites W2567699986 @default.
• W3209055387 cites W2588025094 @default.
• W3209055387 cites W2591293607 @default.
• W3209055387 cites W2595038576 @default.
• W3209055387 cites W2606549900 @default.
• W3209055387 cites W2622807556 @default.
• W3209055387 cites W2730378541 @default.
• W3209055387 cites W2735081493 @default.
• W3209055387 cites W2740893736 @default.
• W3209055387 cites W2742183055 @default.
• W3209055387 cites W2757902459 @default.
• W3209055387 cites W2761570368 @default.
• W3209055387 cites W2774947569 @default.
• W3209055387 cites W2782487815 @default.
• W3209055387 cites W2802810292 @default.
• W3209055387 cites W2804716129 @default.
• W3209055387 cites W2808642658 @default.
• W3209055387 cites W2809922718 @default.
• W3209055387 cites W2810472176 @default.
• W3209055387 cites W2893554173 @default.
• W3209055387 cites W2897379107 @default.
• W3209055387 cites W2907207765 @default.
• W3209055387 cites W2911549495 @default.

• next