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- W3209088051 abstract "An efficient taurine-catalyzed green multicomponent approach has been described for the first time to synthesize densely substituted therapeutic core dihydropyrano[2,3-c]pyrazoles. Applications of the developed synthetic strategies and technologies revealed the synthesis of a series of newly designed 1,4-dihydropyrano[2,3-c]pyrazoles containing isonicotinamide, spirooxindole, and indole moieties. Detailed in silico analysis of the synthesized analogues revealed their potential to bind wild-type and antibiotic-resistant variants of dihydrofolate reductase, a principal drug target enzyme for emerging antibiotic-resistant pathogenic Staphylococcus aureus strains. Hence, the synthesized dihydropyrano[2,3-c]pyrazole derivatives presented herein hold immense promise to develop future antistaphylococcal therapeutic agents." @default.
- W3209088051 created "2021-11-08" @default.
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- W3209088051 date "2021-11-02" @default.
- W3209088051 modified "2023-10-12" @default.
- W3209088051 title "Design, Synthesis, and Biological Evaluation of Densely Substituted Dihydropyrano[2,3-<i>c</i>]pyrazoles <i>via</i> a Taurine-Catalyzed Green Multicomponent Approach" @default.
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- W3209088051 doi "https://doi.org/10.1021/acsomega.1c04773" @default.
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