FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209099042> ?p ?o ?g. }

• W3209099042 endingPage "1468" @default.
• W3209099042 startingPage "1452" @default.
• W3209099042 abstract "Hematopoietic cell transplantation from HLA-haploidentical related donors is increasingly used to treat hematologic cancers; however, characteristics of the optimal haploidentical donor have not been established. We studied the role of donor HLA mismatching in graft-versus-host disease (GVHD), disease recurrence, and survival after haploidentical donor transplantation with posttransplantation cyclophosphamide (PTCy) for 1434 acute leukemia or myelodysplastic syndrome patients reported to the Center for International Blood and Marrow Transplant Research. The impact of mismatching in the graft-versus-host vector for HLA-A, -B, -C, -DRB1, and -DQB1 alleles, the HLA-B leader, and HLA-DPB1 T-cell epitope (TCE) were studied using multivariable regression methods. Outcome was associated with HLA (mis)matches at individual loci rather than the total number of HLA mismatches. HLA-DRB1 mismatches were associated with lower risk of disease recurrence. HLA-DRB1 mismatching with HLA-DQB1 matching correlated with improved disease-free survival. HLA-B leader matching and HLA-DPB1 TCE-nonpermissive mismatching were each associated with improved overall survival. HLA-C matching lowered chronic GVHD risk, and the level of HLA-C expression correlated with transplant-related mortality. Matching status at the HLA-B leader and HLA-DRB1, -DQB1, and -DPB1 predicted disease-free survival, as did patient and donor cytomegalovirus serostatus, patient age, and comorbidity index. A web-based tool was developed to facilitate selection of the best haploidentical-related donor by calculating disease-free survival based on these characteristics. In conclusion, HLA factors influence the success of haploidentical transplantation with PTCy. HLA-DRB1 and -DPB1 mismatching and HLA-C, -B leader, and -DQB1 matching are favorable. Consideration of HLA factors may help to optimize the selection of haploidentical related donors." @default.
• W3209099042 created "2021-11-08" @default.
• W3209099042 creator A5006999192 @default.
• W3209099042 creator A5009156966 @default.
• W3209099042 creator A5019858492 @default.
• W3209099042 creator A5031390636 @default.
• W3209099042 creator A5032478325 @default.
• W3209099042 creator A5041206856 @default.
• W3209099042 creator A5042176968 @default.
• W3209099042 creator A5050581544 @default.
• W3209099042 creator A5052064208 @default.
• W3209099042 creator A5052684200 @default.
• W3209099042 creator A5054084140 @default.
• W3209099042 creator A5060725545 @default.
• W3209099042 creator A5061859839 @default.
• W3209099042 creator A5062691289 @default.
• W3209099042 creator A5064818358 @default.
• W3209099042 creator A5065373363 @default.
• W3209099042 creator A5068492086 @default.
• W3209099042 creator A5069297637 @default.
• W3209099042 creator A5070378721 @default.
• W3209099042 creator A5078600949 @default.
• W3209099042 creator A5085142676 @default.
• W3209099042 creator A5086380393 @default.
• W3209099042 creator A5086490383 @default.
• W3209099042 date "2022-03-10" @default.
• W3209099042 modified "2023-10-06" @default.
• W3209099042 title "HLA informs risk predictions after haploidentical stem cell transplantation with posttransplantation cyclophosphamide" @default.
• W3209099042 cites W1511201911 @default.
• W3209099042 cites W1605634265 @default.
• W3209099042 cites W1654809115 @default.
• W3209099042 cites W1964653209 @default.
• W3209099042 cites W1967759562 @default.
• W3209099042 cites W1978164777 @default.
• W3209099042 cites W1978474777 @default.
• W3209099042 cites W2002547051 @default.
• W3209099042 cites W2042575416 @default.
• W3209099042 cites W2054520032 @default.
• W3209099042 cites W2056892179 @default.
• W3209099042 cites W2060578002 @default.
• W3209099042 cites W2061069485 @default.
• W3209099042 cites W2066886754 @default.
• W3209099042 cites W2070414796 @default.
• W3209099042 cites W2072290737 @default.
• W3209099042 cites W2104662701 @default.
• W3209099042 cites W2118987611 @default.
• W3209099042 cites W2142493118 @default.
• W3209099042 cites W2152591595 @default.
• W3209099042 cites W2158811848 @default.
• W3209099042 cites W2258080942 @default.
• W3209099042 cites W2346085775 @default.
• W3209099042 cites W2520006964 @default.
• W3209099042 cites W2520496580 @default.
• W3209099042 cites W2573678725 @default.
• W3209099042 cites W2606761729 @default.
• W3209099042 cites W2621741324 @default.
• W3209099042 cites W2763445588 @default.
• W3209099042 cites W2763653175 @default.
• W3209099042 cites W2783633607 @default.
• W3209099042 cites W2786059331 @default.
• W3209099042 cites W2788172857 @default.
• W3209099042 cites W2898648224 @default.
• W3209099042 cites W2925256229 @default.
• W3209099042 cites W2976007503 @default.
• W3209099042 cites W2981360631 @default.
• W3209099042 cites W3031910130 @default.
• W3209099042 cites W3032875303 @default.
• W3209099042 cites W3039532649 @default.
• W3209099042 cites W3041686036 @default.
• W3209099042 cites W3082296557 @default.
• W3209099042 cites W3095396754 @default.
• W3209099042 cites W3095662705 @default.
• W3209099042 cites W3152392584 @default.
• W3209099042 cites W3200157047 @default.
• W3209099042 doi "https://doi.org/10.1182/blood.2021013443" @default.
• W3209099042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34724567" @default.
• W3209099042 hasPublicationYear "2022" @default.
• W3209099042 type Work @default.
• W3209099042 sameAs 3209099042 @default.
• W3209099042 citedByCount "43" @default.
• W3209099042 countsByYear W32090990422022 @default.
• W3209099042 countsByYear W32090990422023 @default.
• W3209099042 crossrefType "journal-article" @default.
• W3209099042 hasAuthorship W3209099042A5006999192 @default.
• W3209099042 hasAuthorship W3209099042A5009156966 @default.
• W3209099042 hasAuthorship W3209099042A5019858492 @default.
• W3209099042 hasAuthorship W3209099042A5031390636 @default.
• W3209099042 hasAuthorship W3209099042A5032478325 @default.
• W3209099042 hasAuthorship W3209099042A5041206856 @default.
• W3209099042 hasAuthorship W3209099042A5042176968 @default.
• W3209099042 hasAuthorship W3209099042A5050581544 @default.
• W3209099042 hasAuthorship W3209099042A5052064208 @default.
• W3209099042 hasAuthorship W3209099042A5052684200 @default.
• W3209099042 hasAuthorship W3209099042A5054084140 @default.
• W3209099042 hasAuthorship W3209099042A5060725545 @default.
• W3209099042 hasAuthorship W3209099042A5061859839 @default.
• W3209099042 hasAuthorship W3209099042A5062691289 @default.
• W3209099042 hasAuthorship W3209099042A5064818358 @default.

• next