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- W3209111421 abstract "We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of a trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify l-AST from racemic AST. This chemical synthesis provides a source of this novel antibiotic for future drug development." @default.
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- W3209111421 date "2021-01-01" @default.
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- W3209111421 title "Chemical synthesis of the organoarsenical antibiotic arsinothricin" @default.
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- W3209111421 doi "https://doi.org/10.1039/d1ra06770b" @default.
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