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• W3209150533 endingPage "e050886" @default.
• W3209150533 startingPage "e050886" @default.
• W3209150533 abstract "Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure following mastectomy. IBBR techniques are evolving rapidly, with mesh-assisted subpectoral reconstruction becoming the standard of care and more recently, prepectoral techniques being introduced. These muscle-sparing techniques may reduce postoperative pain, avoid implant animation and improve cosmetic outcomes and have been widely adopted into practice. Although small observational studies have failed to demonstrate any differences in the clinical or patient-reported outcomes of prepectoral or subpectoral reconstruction, high-quality comparative evidence of clinical or cost-effectiveness is lacking. A well-designed, adequately powered randomised controlled trial (RCT) is needed to compare the techniques, but breast reconstruction RCTs are challenging. We, therefore, aim to undertake an external pilot RCT (Best-BRA) with an embedded QuinteT Recruitment Intervention (QRI) to determine the feasibility of undertaking a trial comparing prepectoral and subpectoral techniques.Best-BRA is a pragmatic, two-arm, external pilot RCT with an embedded QRI and economic scoping for resource use. Women who require a mastectomy for either breast cancer or risk reduction, elect to have an IBBR and are considered suitable for both prepectoral and subpectoral reconstruction will be recruited and randomised 1:1 between the techniques.The QRI will be implemented in two phases: phase 1, in which sources of recruitment difficulties are rapidly investigated to inform the delivery in phase 2 of tailored interventions to optimise recruitment of patients.Primary outcomes will be (1) recruitment of patients, (2) adherence to trial allocation and (3) outcome completion rates. Outcomes will be reviewed at 12 months to determine the feasibility of a definitive trial.The study has been approved by the National Health Service (NHS) Wales REC 6 (20/WA/0338). Findings will be presented at conferences and in peer-reviewed journals.ISRCTN10081873." @default.
• W3209150533 created "2021-11-08" @default.
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• W3209150533 date "2021-11-01" @default.
• W3209150533 modified "2023-10-05" @default.
• W3209150533 title "Best-BRA (Is subpectoral or prepectoral implant placement best in immediate breast reconstruction?): a protocol for a pilot randomised controlled trial of subpectoral versus prepectoral immediate implant-based breast reconstruction in women following mastectomy" @default.
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• W3209150533 cites W1967269042 @default.
• W3209150533 cites W1971654337 @default.
• W3209150533 cites W1977786430 @default.
• W3209150533 cites W1984880433 @default.
• W3209150533 cites W1986516169 @default.
• W3209150533 cites W1990166011 @default.
• W3209150533 cites W1991084034 @default.
• W3209150533 cites W1991286302 @default.
• W3209150533 cites W1996751671 @default.
• W3209150533 cites W2010127350 @default.
• W3209150533 cites W2011644590 @default.
• W3209150533 cites W2029178468 @default.
• W3209150533 cites W2030993903 @default.
• W3209150533 cites W2037373388 @default.
• W3209150533 cites W2043362735 @default.
• W3209150533 cites W2048036088 @default.
• W3209150533 cites W2065378325 @default.
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• W3209150533 cites W2081971005 @default.
• W3209150533 cites W2093274439 @default.
• W3209150533 cites W2123572561 @default.
• W3209150533 cites W2123909572 @default.
• W3209150533 cites W2137473134 @default.
• W3209150533 cites W2140699438 @default.
• W3209150533 cites W2164208758 @default.
• W3209150533 cites W2171811563 @default.
• W3209150533 cites W2280984691 @default.
• W3209150533 cites W2297678958 @default.
• W3209150533 cites W2315231301 @default.
• W3209150533 cites W2340216461 @default.
• W3209150533 cites W2414442728 @default.
• W3209150533 cites W2494134246 @default.
• W3209150533 cites W2496213529 @default.
• W3209150533 cites W2539317882 @default.
• W3209150533 cites W2563226059 @default.
• W3209150533 cites W2610668584 @default.
• W3209150533 cites W2612805909 @default.
• W3209150533 cites W2741689621 @default.
• W3209150533 cites W2741893593 @default.
• W3209150533 cites W2775603594 @default.
• W3209150533 cites W2784969024 @default.
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• W3209150533 cites W2917915033 @default.
• W3209150533 cites W2918717398 @default.
• W3209150533 cites W2929082691 @default.
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• W3209150533 doi "https://doi.org/10.1136/bmjopen-2021-050886" @default.
• W3209150533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34848516" @default.
• W3209150533 hasPublicationYear "2021" @default.
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