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- W3209274803 abstract "Introduction: Differentiation of gastric mesenchymal tumors without surgical intervention has been difficult historically. We present a case in which a presumed gastrointestinal stromal tumor (GIST) was diagnosed as a benign gastric schwannoma (GS) using advanced endoscopic techniques with immunohistochemical studies. Case Description/Methods: A 68-year-old woman without significant medical history presented to our clinic with progressive episodic abdominal pain, bloating, nausea, vomiting, and diarrhea. Originally diagnosed with gastroesophageal reflux, she was not finding relief with conventional medications. A comprehensive laboratory workup was significant for C. difficile which was treated with a standard course PO vancomycin. Though subsequent testing confirmed eradication of infection, symptoms persisted. Esophagogastroduodenoscopy (EGD) plus colonoscopy was performed to explore for celiac disease, inflammatory bowel disease, and microscopic colitis. EGD unveiled a submucosal gastric lesion at the incisura. Endoscopic ultrasound (EUS) revealed a 10 mm heterogenous lesion located in the submucosal layer. Two fine needle aspiration (FNA) biopsies were taken which came back negative for malignant cells. Treatments including IBguard, VSL #3 probiotics, and low FODMAP diet were then trialed; still she had no relief in symptoms. Imaging was significant for a 1.7 cm gastric mass suggestive of GIST versus leiomyoma. Reevaluation with EGD and EUS revealed the lesion had nearly doubled. Sonographic features showed a 17.6 mm x 20.4 mm hypoechoic lesion originating from the muscularis propria; five FNA biopsies were taken. Biopsies were significant for gastric mucosal cells, submucosal fragments, smooth muscle with immunopositivity for smooth muscle actin and muscle specific actin. Neither CD 117 immunopositive cells nor significant increase in the KI-67 protein were detected. Further analysis revealed a spindle cell neoplasm with peripheral lymphoid cuffing – features consistent with GS. The patient elected to undergo wedge resection of GS resulting in great improvement of symptoms.Figure 1.: EGD and EUS capture of GS. Discussion: Though our patient had significant symptoms associated with her GS, these nerve sheath tumors are typically asymptomatic and benign. The primary technique for differentiating incidentally found GS from other GI mesenchymal tumors such as GIST or leiomyomas is surgical resection followed by histologic evaluation. With advanced endoscopic techniques, patients can be saved such invasive procedures in asymptomatic disease." @default.
- W3209274803 created "2021-11-08" @default.
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- W3209274803 date "2021-10-01" @default.
- W3209274803 modified "2023-09-25" @default.
- W3209274803 title "S2540 Gas, GIST, Or… Gastric Schwannoma? A Rare Cause of Abdominal Pain and Bloating" @default.
- W3209274803 doi "https://doi.org/10.14309/01.ajg.0000783692.62625.65" @default.
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