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- W3209319699 endingPage "7048" @default.
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- W3209319699 abstract "Novel, a series of pyrrolyl-thio alkylated/aryl alkylated benzimidazole derivatives were synthesized via one-pot, the three-component reaction of 5-amino-2-mercaptobenzimidazole, 2,5-dimethoxytetrahydrofuran, and different substituted alkyl/aryl alkyl halides in acetic acid and sodium acetate is described. The newly synthesized scaffolds were purified and confirmed by their spectroscopic (IR, 1H-NMR, 13C-NMR, Mass) and elemental analysis. Further, in silico molecular docking studies were carried out for the synthesized compounds against the colchicine binding site of αβ-tubulin (PDB ID: 1SA0). Among all the synthesized compounds 4j, 4p was shown good binding affinity with colchicine binding site of αβ-tubulin." @default.
- W3209319699 created "2021-11-08" @default.
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- W3209319699 date "2021-10-25" @default.
- W3209319699 modified "2023-09-26" @default.
- W3209319699 title "A Facile One-Pot Synthesis of Benzimidazole-Linked Pyrrole Structural Motifs <i>via</i> Multicomponent Approach: Design, Synthesis, and Molecular Docking Studies" @default.
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- W3209319699 doi "https://doi.org/10.1080/10406638.2021.1995010" @default.
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