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• W3209323868 abstract "Monoamine oxidase (MAO) is capable of catalysing the oxidative deamination of amines and neurotransmitters. MAO plays a pivotal role in maintaining neurotransmitters linked to neurological disorders viz. Alzheimer's disease (AD), Parkinson's disease (PD) etc. Therefore, inhibition of MAO can be implicated to the cure of such diseases. Synthetic MAO inhibitors are known to inhibit MAO activity. However, there are safety issues with synthetic MAO inhibitors and many of their effects are non-selective and irreversible. Contrasting synthetic drugs, plant-derived natural products have been popularized globally owing to their extensive acceptability and applicability, therapeutic potency and minimum side effects which potentiated the possibility of developing reversible, promising MAO inhibitors based on natural products. The present review comprehensively elucidates plant -derived natural reversible MAO inhibitors using the literature from the popular databases such as Google Scholar, Scopus, PubMed and Web of Science. This literature review reports approximately 51 plants that have been evaluated for MAO inhibitory activity. In addition, 93 plant-derived natural compounds were retrieved as MAO inhibitors. Majority of these investigations predominantly utilized an in vitro approach to evaluate the MAO inhibitors in relation to the developing treatments of related neurological diseases. However, in vivo studies and clinical trials are still lacking in evaluating the botanical-based MAO inhibitors. The aim of this review is to retrieve the recent literature to explore the in vitro and in vivo studies of plant-based natural products as MAO inhibitors, their structure-activity relationship and relevant molecular docking analyses and their roles in the emerging therapy against disorders like AD, and PD. Further, the review also discusses the shortcomings in the existing research in order to generate more coordinated and focused research in future." @default.
• W3209323868 created "2021-11-08" @default.
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• W3209323868 date "2022-05-01" @default.
• W3209323868 modified "2023-10-17" @default.
• W3209323868 title "Promising botanical-derived monoamine oxidase (MAO) inhibitors: pharmacological aspects and structure-activity studies" @default.
• W3209323868 cites W123119829 @default.
• W3209323868 cites W1730569001 @default.
• W3209323868 cites W1964321541 @default.
• W3209323868 cites W1965983395 @default.
• W3209323868 cites W1967041070 @default.
• W3209323868 cites W1967896158 @default.
• W3209323868 cites W1972899609 @default.
• W3209323868 cites W1973183259 @default.
• W3209323868 cites W1977572292 @default.
• W3209323868 cites W1977715850 @default.
• W3209323868 cites W1981864637 @default.
• W3209323868 cites W1982064932 @default.
• W3209323868 cites W1983551396 @default.
• W3209323868 cites W1985662169 @default.
• W3209323868 cites W1993318544 @default.
• W3209323868 cites W2000158828 @default.
• W3209323868 cites W2001957776 @default.
• W3209323868 cites W2005416088 @default.
• W3209323868 cites W2007487695 @default.
• W3209323868 cites W2012244264 @default.
• W3209323868 cites W2014970890 @default.
• W3209323868 cites W2018545934 @default.
• W3209323868 cites W2020014475 @default.
• W3209323868 cites W2024261537 @default.
• W3209323868 cites W2024770800 @default.
• W3209323868 cites W2027966411 @default.
• W3209323868 cites W2028048944 @default.
• W3209323868 cites W2028469253 @default.
• W3209323868 cites W2032058589 @default.
• W3209323868 cites W2033122302 @default.
• W3209323868 cites W2037039276 @default.
• W3209323868 cites W2040056112 @default.
• W3209323868 cites W2046736680 @default.
• W3209323868 cites W2048857700 @default.
• W3209323868 cites W2052335127 @default.
• W3209323868 cites W2057133839 @default.
• W3209323868 cites W2058494541 @default.
• W3209323868 cites W2063209673 @default.
• W3209323868 cites W2064638159 @default.
• W3209323868 cites W2066080492 @default.
• W3209323868 cites W2068198250 @default.
• W3209323868 cites W2069154304 @default.
• W3209323868 cites W2073261436 @default.
• W3209323868 cites W2074806413 @default.
• W3209323868 cites W2076914045 @default.
• W3209323868 cites W207961661 @default.
• W3209323868 cites W2081674263 @default.
• W3209323868 cites W2086319630 @default.
• W3209323868 cites W2087515552 @default.
• W3209323868 cites W2088783236 @default.
• W3209323868 cites W2089786831 @default.
• W3209323868 cites W2091842787 @default.
• W3209323868 cites W2093065596 @default.
• W3209323868 cites W2093091222 @default.
• W3209323868 cites W2095550859 @default.
• W3209323868 cites W2101258732 @default.
• W3209323868 cites W2108364115 @default.
• W3209323868 cites W2110725190 @default.
• W3209323868 cites W2134996660 @default.
• W3209323868 cites W2136242567 @default.
• W3209323868 cites W2141411625 @default.
• W3209323868 cites W2147643279 @default.
• W3209323868 cites W2161816639 @default.
• W3209323868 cites W2168326866 @default.
• W3209323868 cites W2169624105 @default.
• W3209323868 cites W2237260456 @default.
• W3209323868 cites W2286891740 @default.
• W3209323868 cites W2293086764 @default.
• W3209323868 cites W2314040201 @default.
• W3209323868 cites W2314468284 @default.
• W3209323868 cites W2415540759 @default.
• W3209323868 cites W2508467873 @default.
• W3209323868 cites W2556034050 @default.
• W3209323868 cites W2567913970 @default.
• W3209323868 cites W2579594907 @default.
• W3209323868 cites W2616318791 @default.
• W3209323868 cites W2724570364 @default.
• W3209323868 cites W2760125495 @default.

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